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October 2012 Volume 4 Issue 4

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Article

Cyclin A overexpression is associated with chemosensitivity to paclitaxel‑based chemotherapy in patients with esophageal squamous cell carcinoma

  • Authors:
    • Jun‑Xing Huang
    • Shuang‑Le Shen
    • Mei Lin
    • Wei Xiao
    • Wei‑Chang Chen
    • Mao‑Song Lin
    • Hong Yu
    • Ping Chen
    • Rong‑Yu Qian
  • View Affiliations / Copyright

    Affiliations: Department of Oncology, The People's Hospital of Taizhou, Taizhou Medical School, Nantong and Yangzhou University, Taizhou, Jiangsu 225300, P.R. China, Department of Pathology, The People's Hospital of Taizhou, Taizhou Medical School, Nantong and Yangzhou University, Taizhou, Jiangsu 225300, P.R. China, Department of Gastroenterology, The First Affiliated Hospital of Soochow University, Suzhou, Jiangsu 215006, P.R. China
  • Pages: 607-611
    |
    Published online on: July 20, 2012
       https://doi.org/10.3892/ol.2012.814
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Abstract

The aim of this study was to investigate the correlation between cyclin A expression and efficacy of paclitaxel‑based chemotherapy in patients with esophageal squamous cell carcinoma (ESCC). The expression of cyclin A was examined in 48 newly diagnosed ESCC patients prior to treatment using the MaxVision immunohistochemistry method. The patients received four cycles of paclitaxel‑based chemotherapy, the short‑term treatment efficacy was evaluated and a 3‑year follow‑up was conducted. The response rate was greater in patients with positive cyclin A expression compared with those with negative expression (54.8 vs. 23.5%; χ2=4.373; P<0.05). Univariate and multivariate Cox analysis revealed that clinicopathological stage, degree of differentiation and expression of cyclin A were independent prognosis factors in patients with ESCC following paclitaxel‑based chemotherapy. ESCC patients with positive cyclin A expression demonstrated an increased sensitivity to paclitaxel‑based chemotherapy, suggesting that cyclin A may be used as a marker to predict the treatment efficacy of paclitaxel in patients with ESCC.
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Copy and paste a formatted citation
Spandidos Publications style
Huang JX, Shen SL, Lin M, Xiao W, Chen WC, Lin MS, Yu H, Chen P and Qian RY: Cyclin A overexpression is associated with chemosensitivity to paclitaxel‑based chemotherapy in patients with esophageal squamous cell carcinoma. Oncol Lett 4: 607-611, 2012.
APA
Huang, J., Shen, S., Lin, M., Xiao, W., Chen, W., Lin, M. ... Qian, R. (2012). Cyclin A overexpression is associated with chemosensitivity to paclitaxel‑based chemotherapy in patients with esophageal squamous cell carcinoma. Oncology Letters, 4, 607-611. https://doi.org/10.3892/ol.2012.814
MLA
Huang, J., Shen, S., Lin, M., Xiao, W., Chen, W., Lin, M., Yu, H., Chen, P., Qian, R."Cyclin A overexpression is associated with chemosensitivity to paclitaxel‑based chemotherapy in patients with esophageal squamous cell carcinoma". Oncology Letters 4.4 (2012): 607-611.
Chicago
Huang, J., Shen, S., Lin, M., Xiao, W., Chen, W., Lin, M., Yu, H., Chen, P., Qian, R."Cyclin A overexpression is associated with chemosensitivity to paclitaxel‑based chemotherapy in patients with esophageal squamous cell carcinoma". Oncology Letters 4, no. 4 (2012): 607-611. https://doi.org/10.3892/ol.2012.814
Copy and paste a formatted citation
x
Spandidos Publications style
Huang JX, Shen SL, Lin M, Xiao W, Chen WC, Lin MS, Yu H, Chen P and Qian RY: Cyclin A overexpression is associated with chemosensitivity to paclitaxel‑based chemotherapy in patients with esophageal squamous cell carcinoma. Oncol Lett 4: 607-611, 2012.
APA
Huang, J., Shen, S., Lin, M., Xiao, W., Chen, W., Lin, M. ... Qian, R. (2012). Cyclin A overexpression is associated with chemosensitivity to paclitaxel‑based chemotherapy in patients with esophageal squamous cell carcinoma. Oncology Letters, 4, 607-611. https://doi.org/10.3892/ol.2012.814
MLA
Huang, J., Shen, S., Lin, M., Xiao, W., Chen, W., Lin, M., Yu, H., Chen, P., Qian, R."Cyclin A overexpression is associated with chemosensitivity to paclitaxel‑based chemotherapy in patients with esophageal squamous cell carcinoma". Oncology Letters 4.4 (2012): 607-611.
Chicago
Huang, J., Shen, S., Lin, M., Xiao, W., Chen, W., Lin, M., Yu, H., Chen, P., Qian, R."Cyclin A overexpression is associated with chemosensitivity to paclitaxel‑based chemotherapy in patients with esophageal squamous cell carcinoma". Oncology Letters 4, no. 4 (2012): 607-611. https://doi.org/10.3892/ol.2012.814
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