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Print ISSN: 1792-1074 Online ISSN: 1792-1082
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November 2012 Volume 4 Issue 5

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International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

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Article

miR-155 and miR-31 are differentially expressed in breast cancer patients and are correlated with the estrogen receptor and progesterone receptor status

  • Authors:
    • Zhenduo Lu
    • Yuping Ye
    • Dechuang Jiao
    • Jianhua Qiao
    • Shude Cui
    • Zhenzhen Liu
  • View Affiliations / Copyright

    Affiliations: Breast Cancer Center, Henan Cancer Hospital and Affiliated Cancer Hospital of Zhengzhou University, Zhengzhou, Henan 45008, P.R. China
  • Pages: 1027-1032
    |
    Published online on: August 3, 2012
       https://doi.org/10.3892/ol.2012.841
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Abstract

The purpose of the present study was to determine the tissue and plasma levels of microRNA (miR)-155 and miR-31 in 67 patients with invasive intraductal breast cancer and their correlation with the clinicopathological characteristics. Using a quantitative real-time-PCR (qRT-PCR) assay, it was demonstrated that the plasma levels of miR-155 and miR-31 in patients were 6- and 5-fold higher than those in healthy individuals, respectively (P<0.05). In cancerous tissues, miR-155 expression levels were 5-fold higher compared with those in non-cancerous tissues (P<0.05), whereas no difference was observed with miR-31 expression (P>0.05). The expression levels of miR-155, but not miR-31, were inversely correlated with estrogen receptor (ER) and progesterone receptor (PR) expression (ER, r=-0.353, P=0.003; PR, r=-0.357, P=0.003). The tissue and plasma levels of miR-155 and miR-31 were not correlated with epidermal growth factor receptor-2 (HER-2) expression levels. Furthermore, high levels of plasma miR-155 and miR-31 were identified in the tumors of TNM stage II, lymph node metastasis 0-3 and tumor sizes of 2-5 cm in patients who were aged over 52 years. miR-155 was mainly expressed in patients with a pathology score of 3 for ER or PR expression; miR-31 expression was higher in patients with a pathology score of 2. These results suggest that miR-155 and miR-31 are differentially expressed in breast cancer patients. Their correlation with the clinicopathological characteristics may aid the diagnosis and treatment of invasive intraductal breast cancer.
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Copy and paste a formatted citation
Spandidos Publications style
Lu Z, Ye Y, Jiao D, Qiao J, Cui S and Liu Z: miR-155 and miR-31 are differentially expressed in breast cancer patients and are correlated with the estrogen receptor and progesterone receptor status. Oncol Lett 4: 1027-1032, 2012.
APA
Lu, Z., Ye, Y., Jiao, D., Qiao, J., Cui, S., & Liu, Z. (2012). miR-155 and miR-31 are differentially expressed in breast cancer patients and are correlated with the estrogen receptor and progesterone receptor status. Oncology Letters, 4, 1027-1032. https://doi.org/10.3892/ol.2012.841
MLA
Lu, Z., Ye, Y., Jiao, D., Qiao, J., Cui, S., Liu, Z."miR-155 and miR-31 are differentially expressed in breast cancer patients and are correlated with the estrogen receptor and progesterone receptor status". Oncology Letters 4.5 (2012): 1027-1032.
Chicago
Lu, Z., Ye, Y., Jiao, D., Qiao, J., Cui, S., Liu, Z."miR-155 and miR-31 are differentially expressed in breast cancer patients and are correlated with the estrogen receptor and progesterone receptor status". Oncology Letters 4, no. 5 (2012): 1027-1032. https://doi.org/10.3892/ol.2012.841
Copy and paste a formatted citation
x
Spandidos Publications style
Lu Z, Ye Y, Jiao D, Qiao J, Cui S and Liu Z: miR-155 and miR-31 are differentially expressed in breast cancer patients and are correlated with the estrogen receptor and progesterone receptor status. Oncol Lett 4: 1027-1032, 2012.
APA
Lu, Z., Ye, Y., Jiao, D., Qiao, J., Cui, S., & Liu, Z. (2012). miR-155 and miR-31 are differentially expressed in breast cancer patients and are correlated with the estrogen receptor and progesterone receptor status. Oncology Letters, 4, 1027-1032. https://doi.org/10.3892/ol.2012.841
MLA
Lu, Z., Ye, Y., Jiao, D., Qiao, J., Cui, S., Liu, Z."miR-155 and miR-31 are differentially expressed in breast cancer patients and are correlated with the estrogen receptor and progesterone receptor status". Oncology Letters 4.5 (2012): 1027-1032.
Chicago
Lu, Z., Ye, Y., Jiao, D., Qiao, J., Cui, S., Liu, Z."miR-155 and miR-31 are differentially expressed in breast cancer patients and are correlated with the estrogen receptor and progesterone receptor status". Oncology Letters 4, no. 5 (2012): 1027-1032. https://doi.org/10.3892/ol.2012.841
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