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Print ISSN: 1792-1074 Online ISSN: 1792-1082
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November 2012 Volume 4 Issue 5

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International Journal of Molecular Medicine

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International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

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Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

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Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

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Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

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Article

Prevention of human adenocarcinoma with CpG-ODN in a mouse model

  • Authors:
    • Stephen E. Wright
    • Kathleen A. Rewers-Felkins
    • Nazrul  I. Chowdhury
    • Jewel Ahmed
    • Sanjay K. Srivastava
  • View Affiliations / Copyright

    Affiliations: Women's Health Research Institute, Department of Internal Medicine, Texas Tech University Health Sciences Center, Amarillo, Texas, TX 79106, USA, Department of Biomedical Sciences, School of Pharmacy, Texas Tech University Health Sciences Center, Amarillo, Texas, TX 79106, USA
  • Pages: 1061-1063
    |
    Published online on: August 6, 2012
       https://doi.org/10.3892/ol.2012.849
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Abstract

CpG-ODNs activate various immune cell subsets and induce the production of numerous cytokines. To determine whether a CpG-ODN-activated innate immune system, without the adaptive immune system, was capable of protecting against cancer cell growth, NOD/SCID mice, which do not have T or B cell function but have a functional innate immune system, were used as a model system. NOD/SCID mice were injected subcutaneously with human prostate cancer cells followed by subcutaneous injection of incremental doses of CpG-ODNs. CpG-ODNs displayed a dose-related antitumoral effect leading to the prevention of tumor growth. These results indicate that ODNs are capable of activating the innate immune system and destroying human cancer cells in the absence of the adaptive immune system.
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Copy and paste a formatted citation
Spandidos Publications style
Wright SE, Rewers-Felkins KA, Chowdhury NI, Ahmed J and Srivastava SK: Prevention of human adenocarcinoma with CpG-ODN in a mouse model. Oncol Lett 4: 1061-1063, 2012.
APA
Wright, S.E., Rewers-Felkins, K.A., Chowdhury, N.I., Ahmed, J., & Srivastava, S.K. (2012). Prevention of human adenocarcinoma with CpG-ODN in a mouse model. Oncology Letters, 4, 1061-1063. https://doi.org/10.3892/ol.2012.849
MLA
Wright, S. E., Rewers-Felkins, K. A., Chowdhury, N. I., Ahmed, J., Srivastava, S. K."Prevention of human adenocarcinoma with CpG-ODN in a mouse model". Oncology Letters 4.5 (2012): 1061-1063.
Chicago
Wright, S. E., Rewers-Felkins, K. A., Chowdhury, N. I., Ahmed, J., Srivastava, S. K."Prevention of human adenocarcinoma with CpG-ODN in a mouse model". Oncology Letters 4, no. 5 (2012): 1061-1063. https://doi.org/10.3892/ol.2012.849
Copy and paste a formatted citation
x
Spandidos Publications style
Wright SE, Rewers-Felkins KA, Chowdhury NI, Ahmed J and Srivastava SK: Prevention of human adenocarcinoma with CpG-ODN in a mouse model. Oncol Lett 4: 1061-1063, 2012.
APA
Wright, S.E., Rewers-Felkins, K.A., Chowdhury, N.I., Ahmed, J., & Srivastava, S.K. (2012). Prevention of human adenocarcinoma with CpG-ODN in a mouse model. Oncology Letters, 4, 1061-1063. https://doi.org/10.3892/ol.2012.849
MLA
Wright, S. E., Rewers-Felkins, K. A., Chowdhury, N. I., Ahmed, J., Srivastava, S. K."Prevention of human adenocarcinoma with CpG-ODN in a mouse model". Oncology Letters 4.5 (2012): 1061-1063.
Chicago
Wright, S. E., Rewers-Felkins, K. A., Chowdhury, N. I., Ahmed, J., Srivastava, S. K."Prevention of human adenocarcinoma with CpG-ODN in a mouse model". Oncology Letters 4, no. 5 (2012): 1061-1063. https://doi.org/10.3892/ol.2012.849
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