Prevention of human adenocarcinoma with CpG-ODN in a mouse model

Wright,Stephen  E.; Rewers-Felkins,Kathleen  A.; Chowdhury,Nazrul  I.; Ahmed,Jewel; Srivastava,Sanjay  K.

doi:10.3892/ol.2012.849

Prevention of human adenocarcinoma with CpG-ODN in a mouse model

Authors:
- Stephen E. Wright
- Kathleen A. Rewers-Felkins
- Nazrul I. Chowdhury
- Jewel Ahmed
- Sanjay K. Srivastava
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Affiliations: Women's Health Research Institute, Department of Internal Medicine, Texas Tech University Health Sciences Center, Amarillo, Texas, TX 79106, USA, Department of Biomedical Sciences, School of Pharmacy, Texas Tech University Health Sciences Center, Amarillo, Texas, TX 79106, USA
Published online on: August 6, 2012 https://doi.org/10.3892/ol.2012.849
Pages: 1061-1063

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Abstract

CpG-ODNs activate various immune cell subsets and induce the production of numerous cytokines. To determine whether a CpG-ODN-activated innate immune system, without the adaptive immune system, was capable of protecting against cancer cell growth, NOD/SCID mice, which do not have T or B cell function but have a functional innate immune system, were used as a model system. NOD/SCID mice were injected subcutaneously with human prostate cancer cells followed by subcutaneous injection of incremental doses of CpG-ODNs. CpG-ODNs displayed a dose-related antitumoral effect leading to the prevention of tumor growth. These results indicate that ODNs are capable of activating the innate immune system and destroying human cancer cells in the absence of the adaptive immune system.

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