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Nedaplatin and irinotecan combination therapy is equally effective and less toxic than cisplatin and irinotecan for patients with primary clear cell adenocarcinoma of the ovary and recurrent ovarian carcinoma

  • Authors:
    • Shizuo Machida
    • Tomomi Sato
    • Hiroyuki Fujiwara
    • Yasushi Saga
    • Yuji Takei
    • Akiyo Taneichi
    • Hiroaki Nonaka
    • Mitsuaki Suzuki

  • View Affiliations

  • Published online on: August 6, 2012     https://doi.org/10.3892/ol.2012.853
  • Pages: 1017-1022
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Abstract

This study retrospectively compared nedaplatin and irinotecan hydrochloride (NDP/CPT) combination therapy with cisplatin and irinotecan hydrochloride therapy (CDDP/CPT) for efficacy and adverse events in the treatment of clear cell adenocarcinoma of the ovary (CCC) and recurrent ovarian carcinoma. A total of 115 patients were included in the present study. NDP/CPT was administered intravenously every 4 weeks (NDP, 60 mg/m2 on day 1; CPT, 50 mg/m2 on days 1, 8 and 15). CDDP/CPT was also administered intravenously (CDDP, 60 mg/m2 on day 1; CPT, 60 mg/m2 on days 1, 8 and 15). Patients with primary CCC were treated with NDP/CPT in 29 cases and CDDP/CPT in 20 cases. Patients with recurrent ovarian carcinoma were treated with NDP/CPT and CDDP/CPT in 33 cases each. No significant difference was observed in the 5-year overall survival (OS)/progression-free survival (PFS) of patients with primary CCC, with the exception of those patients with stages Ia and Ic(b) who underwent NDP/CPT and CDDP/CPT treatments (OS: 58%, PFS: 40% and OS: 53% and PFS: 47%, respectively). No significant differences were found in the response rates to NDP/CPT and CDDP/CPT in patients with recurrent ovarian carcinoma (27 and 18%, respectively). Similarly, there were no significant differences in the 5-year OS and PFS of patients with recurrent ovarian carcinoma treated with NDP/CPT or CDDP/CPT (OS: 15%, PFS: 3% and OS: 18%, PFS: 6%, respectively). In terms of the hematological toxicity of grade 3 or above and non-hematological toxicity of grade 2 or above in patients treated with NDP/CPT and CDDP/CPT, respectively, neutropenia was 23 and 56%; anemia, 1, and 20%; thrombocytopenia, 0 and 5%; nausea, 20 and 52%; diarrhea, 14 and 25%; and fever, 2 and 11%. Accordingly, NDP/CPT indicated mild toxicity, and was therefore equally effective and less toxic than CDDP/CPT in the treatment of primary CCC and recurrent ovarian carcinoma.
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November 2012
Volume 4 Issue 5

Print ISSN: 1792-1074
Online ISSN:1792-1082

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  • Journal Metrics
  • Impact Factor: 2.9
  • Ranked Oncology
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  • CiteScore: 6.3
  • CiteScore Rank: Q2: #119/366 Oncology
  • Source Normalized Impact per Paper (SNIP): 0.725
  • SCImago Journal Rank (SJR): 0.639
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Spandidos Publications style
Machida S, Sato T, Fujiwara H, Saga Y, Takei Y, Taneichi A, Nonaka H and Suzuki M: Nedaplatin and irinotecan combination therapy is equally effective and less toxic than cisplatin and irinotecan for patients with primary clear cell adenocarcinoma of the ovary and recurrent ovarian carcinoma. Oncol Lett 4: 1017-1022, 2012
APA
Machida, S., Sato, T., Fujiwara, H., Saga, Y., Takei, Y., Taneichi, A. ... Suzuki, M. (2012). Nedaplatin and irinotecan combination therapy is equally effective and less toxic than cisplatin and irinotecan for patients with primary clear cell adenocarcinoma of the ovary and recurrent ovarian carcinoma. Oncology Letters, 4, 1017-1022. https://doi.org/10.3892/ol.2012.853
MLA
Machida, S., Sato, T., Fujiwara, H., Saga, Y., Takei, Y., Taneichi, A., Nonaka, H., Suzuki, M."Nedaplatin and irinotecan combination therapy is equally effective and less toxic than cisplatin and irinotecan for patients with primary clear cell adenocarcinoma of the ovary and recurrent ovarian carcinoma". Oncology Letters 4.5 (2012): 1017-1022.
Chicago
Machida, S., Sato, T., Fujiwara, H., Saga, Y., Takei, Y., Taneichi, A., Nonaka, H., Suzuki, M."Nedaplatin and irinotecan combination therapy is equally effective and less toxic than cisplatin and irinotecan for patients with primary clear cell adenocarcinoma of the ovary and recurrent ovarian carcinoma". Oncology Letters 4, no. 5 (2012): 1017-1022. https://doi.org/10.3892/ol.2012.853