A novel taspine analog, HMQ1611, inhibits growth of non-small cell lung cancer by inhibiting angiogenesis

  • Authors:
    • Wen Lu
    • Bingling Dai
    • Weina Ma
    • Yanmin Zhang
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  • Published online on: August 8, 2012     https://doi.org/10.3892/ol.2012.855
  • Pages: 1109-1113
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Abstract

In the present study, we investigated the antitumor activity of HMQ1611, a novel synthetic taspine derivative, in vivo and evaluated associated potential antiangiogenesis mechanisms. The proliferation of A549 cells was examined by WST-1 assay in vitro. Tube formation and lung tissue vessel models were used to observe the antiangiogenic activity of HMQ1611. In addition, vascular enodthelial growth factor (VEGF) secretion and KDR kinase activities were measured by ELISA and the HTRF®KinEASETM-TK assay. In vivo, the antitumor activity was assessed by implantation of A549 cells in athymic mice. The results showed that HMQ1611 inhibited A549 cell proliferation and VEGF secretion, while it significantly inhibited tube formation and tissue vascularization. Furthermore, HMQ1611 inhibited A549 xenograft tumor growth. In conclusion, the results of our study suggest that HMQ1611 has latent properties for the inhibition of angiogenesis which are involved in its antitumor activity.
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November 2012
Volume 4 Issue 5

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Spandidos Publications style
Lu W, Dai B, Ma W and Zhang Y: A novel taspine analog, HMQ1611, inhibits growth of non-small cell lung cancer by inhibiting angiogenesis. Oncol Lett 4: 1109-1113, 2012.
APA
Lu, W., Dai, B., Ma, W., & Zhang, Y. (2012). A novel taspine analog, HMQ1611, inhibits growth of non-small cell lung cancer by inhibiting angiogenesis. Oncology Letters, 4, 1109-1113. https://doi.org/10.3892/ol.2012.855
MLA
Lu, W., Dai, B., Ma, W., Zhang, Y."A novel taspine analog, HMQ1611, inhibits growth of non-small cell lung cancer by inhibiting angiogenesis". Oncology Letters 4.5 (2012): 1109-1113.
Chicago
Lu, W., Dai, B., Ma, W., Zhang, Y."A novel taspine analog, HMQ1611, inhibits growth of non-small cell lung cancer by inhibiting angiogenesis". Oncology Letters 4, no. 5 (2012): 1109-1113. https://doi.org/10.3892/ol.2012.855