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Article

Effectiveness of the bevacizumab‑irinotecan regimen in the treatment of recurrent glioblastoma multiforme: Comparison with other second‑line treatments without this regimen

  • Authors:
    • Daniel Ruiz-Sánchez
    • Miguel Alaguero Calero
    • Alejandro José Sastre-Heres
    • María Teresa Iglesias García
    • Miguel Angel Calleja Hernandez
    • Fernando Martínez Martinez
    • Jaime Peña‑Díaz
  • View Affiliations / Copyright

    Affiliations: Hospital Pharmacy Department, Central University Hospital of Asturias, Oviedo, Asturias 33006, Spain, Hospital Pharmacy Department, Virgen de las Nieves Hospital, Granada 18014, Spain, Faculty of Pharmacy, University of Granada, Granada 18071, Spain
  • Pages: 1114-1118
    |
    Published online on: August 14, 2012
       https://doi.org/10.3892/ol.2012.861
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Abstract

A retrospective cohort study was conducted to analyse the effectiveness of bevacizumab and irinotecan (BVZ/CPT‑11) as a second‑line treatment in patients with primary glioblastoma multiforme (GBM) in comparison with a control group that were not administered BVZ/CPT‑11 at the first recurrence. The difference in overall survival (OS) between the two groups was used as a predictor of effectiveness. OS was calculated according to prognostic factors and gender. A total of 28 and 32 patients were enrolled in the BVZ/CPT‑11 cohort and control group, respectively. The median OS was 17.94 months (95% CI, 14.91‑20.96) in the BVZ/CPT‑11 treatment cohort and 10.97 months (95% CI, 7.65‑14.30) in the control cohort. The results obtained on the effectiveness of BVZ/CPT‑11 treatment in patients with primary GBM are consistent with data from previous studies. No significant differences were identified in OS based on prognostic factors; therefore, the latter cannot be used to select patients who would incur the greatest benefits from BVZ/CPT‑11 treatment.
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Copy and paste a formatted citation
Spandidos Publications style
Ruiz-Sánchez D, Alaguero Calero M, Sastre-Heres AJ, Iglesias García MT, Calleja Hernandez MA, Martínez Martinez F and Peña‑Díaz J: Effectiveness of the bevacizumab‑irinotecan regimen in the treatment of recurrent glioblastoma multiforme: Comparison with other second‑line treatments without this regimen. Oncol Lett 4: 1114-1118, 2012.
APA
Ruiz-Sánchez, D., Alaguero Calero, M., Sastre-Heres, A.J., Iglesias García, M.T., Calleja Hernandez, M.A., Martínez Martinez, F., & Peña‑Díaz, J. (2012). Effectiveness of the bevacizumab‑irinotecan regimen in the treatment of recurrent glioblastoma multiforme: Comparison with other second‑line treatments without this regimen. Oncology Letters, 4, 1114-1118. https://doi.org/10.3892/ol.2012.861
MLA
Ruiz-Sánchez, D., Alaguero Calero, M., Sastre-Heres, A. J., Iglesias García, M. T., Calleja Hernandez, M. A., Martínez Martinez, F., Peña‑Díaz, J."Effectiveness of the bevacizumab‑irinotecan regimen in the treatment of recurrent glioblastoma multiforme: Comparison with other second‑line treatments without this regimen". Oncology Letters 4.5 (2012): 1114-1118.
Chicago
Ruiz-Sánchez, D., Alaguero Calero, M., Sastre-Heres, A. J., Iglesias García, M. T., Calleja Hernandez, M. A., Martínez Martinez, F., Peña‑Díaz, J."Effectiveness of the bevacizumab‑irinotecan regimen in the treatment of recurrent glioblastoma multiforme: Comparison with other second‑line treatments without this regimen". Oncology Letters 4, no. 5 (2012): 1114-1118. https://doi.org/10.3892/ol.2012.861
Copy and paste a formatted citation
x
Spandidos Publications style
Ruiz-Sánchez D, Alaguero Calero M, Sastre-Heres AJ, Iglesias García MT, Calleja Hernandez MA, Martínez Martinez F and Peña‑Díaz J: Effectiveness of the bevacizumab‑irinotecan regimen in the treatment of recurrent glioblastoma multiforme: Comparison with other second‑line treatments without this regimen. Oncol Lett 4: 1114-1118, 2012.
APA
Ruiz-Sánchez, D., Alaguero Calero, M., Sastre-Heres, A.J., Iglesias García, M.T., Calleja Hernandez, M.A., Martínez Martinez, F., & Peña‑Díaz, J. (2012). Effectiveness of the bevacizumab‑irinotecan regimen in the treatment of recurrent glioblastoma multiforme: Comparison with other second‑line treatments without this regimen. Oncology Letters, 4, 1114-1118. https://doi.org/10.3892/ol.2012.861
MLA
Ruiz-Sánchez, D., Alaguero Calero, M., Sastre-Heres, A. J., Iglesias García, M. T., Calleja Hernandez, M. A., Martínez Martinez, F., Peña‑Díaz, J."Effectiveness of the bevacizumab‑irinotecan regimen in the treatment of recurrent glioblastoma multiforme: Comparison with other second‑line treatments without this regimen". Oncology Letters 4.5 (2012): 1114-1118.
Chicago
Ruiz-Sánchez, D., Alaguero Calero, M., Sastre-Heres, A. J., Iglesias García, M. T., Calleja Hernandez, M. A., Martínez Martinez, F., Peña‑Díaz, J."Effectiveness of the bevacizumab‑irinotecan regimen in the treatment of recurrent glioblastoma multiforme: Comparison with other second‑line treatments without this regimen". Oncology Letters 4, no. 5 (2012): 1114-1118. https://doi.org/10.3892/ol.2012.861
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