Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Oncology Letters
Join Editorial Board Propose a Special Issue
Print ISSN: 1792-1074 Online ISSN: 1792-1082
Journal Cover
November 2012 Volume 4 Issue 5

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
November 2012 Volume 4 Issue 5

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article

Changes in microRNA expression in the MG-63 osteosarcoma cell line compared with osteoblasts

  • Authors:
    • Hao Hu
    • Yi Zhang
    • Xian-Hua Cai
    • Ji-Feng Huang
    • Lin Cai
  • View Affiliations / Copyright

    Affiliations: Department of Orthopedics, Wuhan General Hospital of Guangzhou Command, Wuhan, Hubei, P.R. China, Department of Orthopedics, Zhongnan Hospital, Wuhan University, Wuhan, Hubei, P.R. China
  • Pages: 1037-1042
    |
    Published online on: August 16, 2012
       https://doi.org/10.3892/ol.2012.866
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

Osteosarcoma (OS) is the most common primary malignant bone tumor, particularly in adolescents and young adults. Early diagnosis remains a significant problem in the clinical treatment of OS as we remain far from a comprehensive understanding of the molecular genetic mechanisms and the biology involved. In addition, microRNAs (miRNAs or miRs), a large family of small non-coding RNAs, may provide a greater understanding of OS as they play a complex role in gene expression regulation in vitro and in vivo. In the current study, the differential expression profiles of miRNAs between OS and osteoblast cell lines were investigated by miRNA microarrays and real-time quantitative PCR (RT-qPCR). A total of 268 miRNAs were identified that were significantly dysregulated in OS compared with the osteoblast cell line, including miR-9, miR-99, miR-195, miR-148a and miR-181a, which had been validated as overexpressed, and miR-143, miR-145, miR-335 and miR-539, which were confirmed to be downregulated. This differential expression may aid future OS diagnosis and prognosis prediction and illustration of the potential mechanisms in the oncogenesis, development and metastasis of OS. Bioinformatic research on these differentially expressed miRNAs suggests that they are able to regulate the biological behaviors of OS in a complex and effective manner. Further study on the function of these miRNAs is likely to provide new insights into OS biology and treatment.
View Figures

Figure 1

Figure 2

View References

1. 

A JemalR SiegelE WardT MurrayJ XuMJ ThunCancer statistics, 2007CA Cancer J Clin574366200710.3322/canjclin.57.1.43

2. 

PJ MesserschmittAN RettewRE BrookoverRM GarciaPJ GettyEM GreenfieldSpecific tyrosine kinase inhibitors regulate human osteosarcoma cells in vitroClin Orthop Relat Res46621682175200810.1007/s11999-008-0338-918607665

3. 

G BacciA LonghiM VersariM MercuriA BriccoliP PicciPrognostic factors for osteosarcoma of the extremity treated with neoadjuvant chemotherapy: 15-year experience in 789 patients treated at a single institutionCancer10611541161200616421923

4. 

A LonghiC ErraniM De PaolisM MercuriG BacciPrimary bone osteosarcoma in the pediatric age: state of the artCancer Treat Rev32423436200610.1016/j.ctrv.2006.05.00516860938

5. 

Y ZhangRX WeiXB ZhuL CaiW JinH HuTanshinone IIA induces apoptosis and inhibits the proliferation, migration and invasion of the osteosarcoma MG-63 cell line in vitroAnticancer Drugs23212219201210.1097/CAD.0b013e32834e559222126901

6. 

E KobayashiFJ HornicekZ DuanMicroRNA involvement in osteosarcomaSarcoma2012359739201210.1155/2012/35973922550419

7. 

RR LullaFF CostaJM BischofIdentification of differentially expressed microRNAs in osteosarcomaSarcoma2011732690201110.1155/2011/73269021789031

8. 

A LujambioSW LoweThe microcosmos of cancerNature482347355201210.1038/nature1088822337054

9. 

V RottiersAM NäärMicroRNAs in metabolism and metabolic disordersNat Rev Mol Cell Biol13239250201210.1038/nrm331322436747

10. 

W ZhangME DolanThe emerging role of microRNAs in drug responsesCurr Opin Mol Ther12695702201021154161

11. 

L WangAL ObergYW AsmannGenome-wide transcriptional profiling reveals microRNA-correlated genes and biological processes in human lymphoblastoid cell linesPLoS One11e5878200910.1371/journal.pone.000587819517021

12. 

H ZhaoJ ShenL MedicoD WangCB AmbrosoneS LiuA pilot study of circulating miRNAs as potential biomarkers of early stage breast cancerPLoS One5e13735201010.1371/journal.pone.001373521060830

13. 

L GuoY LiuY BaiY SunF XiaoY GuoGene expression profiling of drug-resistant small cell lung cancer cells by combining microRNA and cDNA expression analysisEur J Cancer4616921702201010.1016/j.ejca.2010.02.04320371173

14. 

T VergoulisIS VlachosP AlexiouTarBase 6.0: capturing the exponential growth of miRNA targets with experimental supportNucleic Acids Res40Database issueD222D229201210.1093/nar/gkr116122135297

15. 

T XuY ZhuY XiongYY GeJP YunSM ZhuangMicroRNA-195 suppresses tumorigenicity and regulates G1/S transition of human hepatocellular carcinoma cellsHepatology50113121200910.1002/hep.2291919441017

16. 

W YeQ LvCK WongThe effect of central loops in miRNA:MRE duplexes on the efficiency of miRNA-mediated gene regulationPLoS One3e1719200810.1371/journal.pone.000171918320040

17. 

L LiuL ChenY XuR LiX DumicroRNA-195 promotes apoptosis and suppresses tumorigenicity of human colorectal cancer cellsBiochem Biophys Res Commun400236240201010.1016/j.bbrc.2010.08.04620727858

18. 

Y MurakamiT YasudaK SaigoComprehensive analysis of microRNA expression patterns in hepatocellular carcinoma and non-tumorous tissuesOncogene2525372345200610.1038/sj.onc.120928316331254

19. 

Y LinJ WuH ChenCyclin-dependent kinase 4 is a novel target in micoRNA-195-mediated cell cycle arrest in bladder cancer cellsFEBS Lett586442447201210.1016/j.febslet.2012.01.02722289176

20. 

C OneyamaJ IkedaD OkuzakiMicroRNA-mediated downregulation of mTOR/FGFR3 controls tumor growth induced by Src-related oncogenic pathwaysOncogene3034893501201110.1038/onc.2011.6321383697

21. 

M HafnerM LandthalerL BurgerTranscriptome-wide identification of RNA-binding protein and microRNA target sites by PAR-CLIPCell141129141201010.1016/j.cell.2010.03.00920371350

22. 

M DoghmanA El WakilB CardinaudRegulation of insulin-like growth factor-mammalian target of rapamycin signaling by microRNA in childhood adrenocortical tumorsCancer Res7046664675201010.1158/0008-5472.CAN-09-397020484036

23. 

LM GuoY PuZ HanMicroRNA-9 inhibits ovarian cancer cell growth through regulation of NF-kappaB1FEBS J27655375546200910.1111/j.1742-4658.2009.07237.x19702828

24. 

L MaJ YoungH PrabhalamiR-9, a MYC/MYCN-activated microRNA, regulates E-cadherin and cancer metastasisNat Cell Biol12247256201020173740

25. 

A GrimsonKK FarhWK JohnstonP Garrett-EngeleLP LimDP BartelMicroRNA targeting specificity in mammals: determinants beyond seed pairingMol Cell2791105200710.1016/j.molcel.2007.06.01717612493

26. 

ST LiffersJB MundingM VogtMicroRNA-148a is down-regulated in human pancreatic ductal adenocarcinomas and regulates cell survival by targeting CDC25BLab Invest9114721479201110.1038/labinvest.2011.9921709669

27. 

B ZhengL LiangC WangMicroRNA-148a suppresses tumor cell invasion and metastasis by downregulating ROCK1 in gastric cancerClin Cancer Res1775747583201110.1158/1078-0432.CCR-11-171421994419

28. 

R CuestaA Martínez-SánchezF GebauermiR-181a regulates cap-dependent translation of p27(kip1) mRNA in myeloid cellsMol Cell Biol2928412851200910.1128/MCB.01971-0819273599

29. 

W ZhuX ShanT WangY ShuP LiumiR-181b modulates multidrug resistance by targeting BCL2 in human cancer cell linesInt J Cancer12725202529201010.1002/ijc.2526020162574

30. 

KH ShinSD BaeHS HongRH KimMK KangNH ParkmiR-181a shows tumor suppressive effect against oral squamous cell carcinoma cells by downregulating K-rasBiochem Biophys Res Commun404896902201110.1016/j.bbrc.2010.12.05521167132

31. 

J JiT YamashitaA BudhuIdentification of microRNA-181 by genome- wide screening as a critical player in EpCAM-positive hepatic cancer stem cellsHepatology50472480200910.1002/hep.2298919585654

32. 

X ZhangY NieY DuJ CaoB ShenY LiMicroRNA-181a promotes gastric cancer by negatively regulating tumor suppressor KLF6Tumour Biol33921928201210.1007/s13277-012-0414-322581522

33. 

T ChiyomaruH EnokidaS TataranomiR-145 and miR-133a function as tumour suppressors and directly regulate FSCN1 expression in bladder cancerBr J Cancer102883891201010.1038/sj.bjc.660557020160723

34. 

M KanoN SekiN KikkawamiR-145, miR-133a and miR-133b: Tumor-suppressive miRNAs target FSCN1 in esophageal squamous cell carcinomaInt J Cancer12728042814201010.1002/ijc.2528421351259

35. 

J ZhangQ SunZ ZhangS GeZG HanWT ChenLoss of microRNA- 143/145 disturbs cellular growth and apoptosis of human epithelial cancers by impairing the MDM2-p53 feedback loopOncogene2810381046201222330136

36. 

Y AkaoY NakagawaT NaoeMicroRNA-143 and -145 in colon cancerDNA Cell Biol26311320200710.1089/dna.2006.055017504027

37. 

M OsakiF TakeshitaY SugimotoMicroRNA-143 regulates human osteosarcoma metastasis by regulating matrix metalloprotease-13 expressionMol Ther1911231130201110.1038/mt.2011.5321427707

38. 

PM BorralhoBT KrenRE CastroIB da SilvaCJ SteerCM RodriguesMicroRNA-143 reduces viability and increases sensitivity to 5-fluorouracil in HCT116 human colorectal cancer cellsFEBS J27666896700200910.1111/j.1742-4658.2009.07383.x19843160

39. 

X ChenX GuoH ZhangRole of miR-143 targeting KRAS in colorectal tumorigenesisOncogene2813851392200910.1038/onc.2008.47419137007

40. 

H HeynM EngelmannS SchreekMicroRNA miR-335 is crucial for the BRCA1 regulatory cascade in breast cancer developmentInt J Cancer12927972806201110.1002/ijc.2596221618216

41. 

SF TavazoieC AlarcónT OskarssonEndogenous human microRNAs that suppress breast cancer metastasisNature451147152200810.1038/nature0648718185580

42. 

YN LeeS BrandalP NoelKIT signaling regulates MITF expression through miRNAs in normal and malignant mast cell proliferationBlood11736293640201110.1182/blood-2010-07-29354821273305

43. 

SK PatnaikE KannistoS YendamuriOverexpression of microRNA miR-30a or miR-191 in A549 lung cancer or BEAS-2B normal lung cell lines does not alter phenotypePLoS One5e9219201010.1371/journal.pone.000921920169152

44. 

J KimDM CoffeyCJ CreightonZ YuSM HawkinsMM MatzukHigh-grade serous ovarian cancer arises from fallopian tube in a mouse modelProc Natl Acad Sci USA10939213926201210.1073/pnas.111713510922331912

45. 

P Puerta-GilR García-BaqueroAY JiamiR-143, miR-222 and miR-452 are useful as tumor stratification and noninvasive diagnostic biomarkers for bladder cancerAm J Pathol18018081815201210.1016/j.ajpath.2012.01.03422426337

46. 

MA CortezJW WelshGA CalinCirculating microRNAs as noninvasive biomarkers in breast cancerRecent Results Cancer Res195151161201210.1007/978-3-642-28160-0_1322527502

47. 

JT MendellEN OlsonMicroRNAs in stress signaling and human diseaseCell14811721187201210.1016/j.cell.2012.02.00522424228

48. 

E Varkonyi-GasicRP HellensQuantitative stem-loop RT-PCR for detection of microRNAsMethods Mol Biol744145157201110.1007/978-1-61779-123-9_1021533691

49. 

T SaitoP SaetromMicroRNAs - targeting and target predictionN Biotechnol27243249201010.1016/j.nbt.2010.02.01620219708

50. 

ME PeterTargeting of mRNAs by multiple miRNAs: the next stepOncogene2921612164201010.1038/onc.2010.5920190803

51. 

S WuS HuangJ DingMultiple microRNAs modulate p21Cip1/Waf1 expression by directly targeting its 3′ untranslated regionOncogene2923022308201020190813

52. 

DW ThomsonCP BrackenGJ GoodallExperimental strategies for microRNA target identificationNucleic Acids Res3968456853201110.1093/nar/gkr33021652644

53. 

TA FaraziJI SpitzerP MorozovT TuschlmiRNAs in human cancerJ Pathol223102115201110.1002/path.2806

54. 

SK ShenoudaSK AlahariMicroRNA function in cancer: oncogene or a tumor suppressor?Cancer Metastasis Rev28369378200910.1007/s10555-009-9188-520012925

55. 

H ZhangX CaiY WangH TangD TongF JimicroRNA-143, down-regulated in osteosarcoma, promotes apoptosis and suppresses tumorigenicity by targeting Bcl-2Oncol Rep2413631369201020878132

56. 

L FanQ WuX XingY WeiZ ShaoMicroRNA-145 targets vascular endothelial growth factor and inhibits invasion and metastasis of osteosarcoma cellsActa Biochim Biophys Sin (Shanghai)44407414201210.1093/abbs/gms01922472569

57. 

D LiX LiuL LinMicroRNA-99a inhibits hepatocellular carcinoma growth and correlates with prognosis of patients with hepatocellular carcinomaJ Biol Chem2863667736685201110.1074/jbc.M111.27056121878637

58. 

D SunYS LeeA MalhotramiR-99 family of MicroRNAs suppresses the expression of prostate-specific antigen and prostate cancer cell proliferationCancer Res7113131324201110.1158/0008-5472.CAN-10-103121212412

59. 

DM ÖzataS CaramutaD Velázquez-FernándezThe role of microRNA deregulation in the pathogenesis of adrenocortical carcinomaEndocr Relat Cancer18643655201121859927

60. 

R MahnLC HeukampS RogenhoferA von RueckerSC MüllerJ EllingerCirculating microRNAs (miRNA) in serum of patients with prostate cancerUrology771265.e916201110.1016/j.urology.2011.01.02021539977

61. 

WC ChoEpigenetic alteration of microRNAs in feces of colorectal cancer and its clinical significanceExpert Rev Mol Diagn11691694201110.1586/erm.11.5721902530

62. 

KB JonesZ SalahS Del MaremiRNA signatures associate with pathogenesis and progression of osteosarcomaCancer Res7218651877201210.1158/0008-5472.CAN-11-266322350417

63. 

NM WhiteTT BaoJ GrigullmiRNA profiling for clear cell renal cell carcinoma: biomarker discovery and identification of potential controls and consequences of miRNA dysregulationJ Urol18610771083201110.1016/j.juro.2011.04.11021784468

64. 

MM VickersJ BarI Gorn-HondermannStage-dependent differential expression of microRNAs in colorectal cancer: potential role as markers of metastatic diseaseClin Exp Metastasis29123132201210.1007/s10585-011-9435-322120473

65. 

M ShuY ZhouW ZhuMicroRNA 335 is required for differentiation of malignant glioma cells induced by activation of cAMP/protein kinase A pathwayMol Pharmacol81292298201210.1124/mol.111.07616622172575

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Hu H, Zhang Y, Cai X, Huang J and Cai L: Changes in microRNA expression in the MG-63 osteosarcoma cell line compared with osteoblasts. Oncol Lett 4: 1037-1042, 2012.
APA
Hu, H., Zhang, Y., Cai, X., Huang, J., & Cai, L. (2012). Changes in microRNA expression in the MG-63 osteosarcoma cell line compared with osteoblasts. Oncology Letters, 4, 1037-1042. https://doi.org/10.3892/ol.2012.866
MLA
Hu, H., Zhang, Y., Cai, X., Huang, J., Cai, L."Changes in microRNA expression in the MG-63 osteosarcoma cell line compared with osteoblasts". Oncology Letters 4.5 (2012): 1037-1042.
Chicago
Hu, H., Zhang, Y., Cai, X., Huang, J., Cai, L."Changes in microRNA expression in the MG-63 osteosarcoma cell line compared with osteoblasts". Oncology Letters 4, no. 5 (2012): 1037-1042. https://doi.org/10.3892/ol.2012.866
Copy and paste a formatted citation
x
Spandidos Publications style
Hu H, Zhang Y, Cai X, Huang J and Cai L: Changes in microRNA expression in the MG-63 osteosarcoma cell line compared with osteoblasts. Oncol Lett 4: 1037-1042, 2012.
APA
Hu, H., Zhang, Y., Cai, X., Huang, J., & Cai, L. (2012). Changes in microRNA expression in the MG-63 osteosarcoma cell line compared with osteoblasts. Oncology Letters, 4, 1037-1042. https://doi.org/10.3892/ol.2012.866
MLA
Hu, H., Zhang, Y., Cai, X., Huang, J., Cai, L."Changes in microRNA expression in the MG-63 osteosarcoma cell line compared with osteoblasts". Oncology Letters 4.5 (2012): 1037-1042.
Chicago
Hu, H., Zhang, Y., Cai, X., Huang, J., Cai, L."Changes in microRNA expression in the MG-63 osteosarcoma cell line compared with osteoblasts". Oncology Letters 4, no. 5 (2012): 1037-1042. https://doi.org/10.3892/ol.2012.866
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team