Clinicopathological characteristics of rectal carcinoid patients undergoing surgical resection

Yamagishi,Daisuke; Matsubara,Nagahide; Noda,Masafumi; Yamano,Tomoki; Tsukamoto,Kiyoshi; Kuno,Takashi; Hamanaka,Mie; Kobayashi,Masayoshi; Ikeuchi,Hiroki; Matsuda,Ikuo; Hirota,Seiichi; Tomita,Naohiro

doi:10.3892/ol.2012.868

November 2012 Volume 4 Issue 5

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November 2012 Volume 4 Issue 5

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Article

Clinicopathological characteristics of rectal carcinoid patients undergoing surgical resection

Authors:
- Daisuke Yamagishi
- Nagahide Matsubara
- Masafumi Noda
- Tomoki Yamano
- Kiyoshi Tsukamoto
- Takashi Kuno
- Mie Hamanaka
- Masayoshi Kobayashi
- Hiroki Ikeuchi
- Ikuo Matsuda
- Seiichi Hirota
- Naohiro Tomita
View Affiliations / Copyright

Affiliations: Division of Lower GI, Department of Surgery, Hyogo College of Medicine, Nishinomiya, Hyogo 663-8501, Japan, Division of Lower GI, Department of Surgery, Hyogo College of Medicine, Nishinomiya, Hyogo 663-8501, Japan, Department of Surgical Pathology, Hyogo College of Medicine, Nishinomiya, Hyogo 663-8501, Japan
Pages: 910-914
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Published online on: August 20, 2012

https://doi.org/10.3892/ol.2012.868
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Abstract

The aim of this study was to clarify the clinical aspects, histopathological features and prognosis of patients with rectal carcinoids, focusing on properties associated with metastasis, in order to gain insights into appropriate management. A total of 20 patients (15 males, 5 females; mean age, 54.9 years; range, 23-71) who underwent surgery for rectal carcinoid tumors at the Department of Colorectal Surgery, Hyogo College of Medicine, between May 2000 and January 2011 were analyzed. Ki-67 immunostaining was performed in 13 cases with available tumor tissue specimens. Of the 20 patients, a radical operation including rectal resection with a lymphadenectomy was performed in 16. The mean tumor size was 11.9 mm (3-25 mm) and lymph node metastasis was confirmed in 9 cases, including 3 with lesions no greater than 7 mm in diameter. Overall, 16 (80%) of the tumors were localized in the submucosal layer and 4 (20%) involved the proper muscle layer. Ki-67 labeling index and lymphovascular invasion were shown to be associated with lymph node and/or distant metastasis by multiple logistic regression analysis, but were not statistically significant in ANOVA findings. Lymph node metastasis from rectal carcinoids, even those smaller than 10 mm in diameter, was not a rare event. More attention should be given to decision-making, including the possibility of endoscopic resection for the treatment of rectal carcinoid tumors regardless of size.

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1.	J SogaCarcinoids and their variant endocrinomas. An analysis of 11842 reported casesJ Exp Clin Cancer Res22517530200315053292
2.	IM ModlinKD LyeM KiddA 5-decade analysis of 13,715 carcinoid tumorsCancer97934959200310.1002/cncr.1110512569593
3.	CJ ShieldsE TiretDC WinterCarcinoid tumors of the rectum: a multi-institutional international collaborationAnn Surg252750755201010.1097/SLA.0b013e3181fb8df621037430
4.	AB JetmoreJE RayJB Gathright JrKM McMullenTC HicksAE TimmckeRectal carcinoids: the most frequent carcinoid tumorDis Colon Rectum35717725199210.1007/BF020503181643994
5.	J SogaEarly-stage carcinoids of the gastrointestinal tract: an analysis of 1914 reported casesCancer10315871595200510.1002/cncr.2093915742328
6.	T KonishiT WatanabeJ KishimotoK KotakeT MutoH NagawaPrognosis and risk factors of metastasis in colorectal carcinoids: results of a nationwide registry over 15 yearsGut56863868200717213340
7.	K HottaT ShimodaY NakanishiD SaitoUsefulness of Ki-67 for predicting the metastatic potential of rectal carcinoidsPathol Int56591596200610.1111/j.1440-1827.2006.02013.x16984615
8.	J SogaCarcinoids of the rectum: an evaluation of 1271 reported casesSurg Today27112119199710.1007/BF023858989017986
9.	H TomodaM FurusawaI HayashiK OkumuraA rectal carcinoid tumor of less than 1 cm in diameter with lymph node metastasis: a case report and a review of the literatureJpn J Surg20468471199010.1007/BF024708342201813
10.	T AkasuY MoriyaK SugiharaTransrectal ultrasonography of a small rectal carcinoid tumor with lymph node metastasis: a case reportJpn J Clin Oncol26112115199610.1093/oxfordjournals.jjco.a0231838609694
11.	T SaitoM IkenagaM YasuiA case of 7 mm rectal carcinoid with lymph node metastasisGan To Kagaku Ryoho36225122532009(In Japanese)
12.	Y OnozatoS KakizakiH IizukaN SoharaM MoriH ItohEndoscopic treatment of rectal carcinoid tumorsDis Colon Rectum53169176201010.1007/DCR.0b013e3181b9db7b20087092
13.	MM HassanA PhanD LiCG DagohoyC LearyJC YaoRisk factors associated with neuroendocrine tumors: A U.S.-based case-control studyInt J Cancer123867873200810.1002/ijc.2352918491401
14.	BN FahyLH TangD KlimstraCarcinoid of the rectum risk stratification (CaRRs): a strategy for preoperative outcome assessmentAnn Surg Oncol1417351743200710.1245/s10434-006-9311-6
15.	MA MaggardJB O’ConnellCY KoUpdated population-based review of carcinoid tumorsAnn Surg240117122200410.1097/01.sla.0000129342.67174.6715213627
16.	YQ ZhangPH ZhouMD XuLong-term efficacy of endoscopic excision of rectal carcinoidsZhonghua Wei Chang Wai Ke Za Zhi114214232008(In Chinese)
17.	CS LandryG BrockCR ScogginsKM McMastersRC Martin IIA proposed staging system for rectal carcinoid tumors based on an analysis of 4701 patientsSurgery144460466200810.1016/j.surg.2008.05.00518707046
18.	A MergD WirtzfeldJ WangR CheneyKB DunnA RajputViability of endoscopic and excisional treatment of early rectal carcinoidsJ Gastrointest Surg11893897200710.1007/s11605-007-0153-817458590
19.	Y FujimotoM OyaH KuroyanagiLymph-node metastases in rectal carcinoidsLangenbecks Arch Surg395139142200810.1007/s00423-008-0438-8
20.	T ScholzenJ GerdesThe Ki-67 protein: from the known and the unknownJ Cell Physiol182311322200010.1002/(SICI)1097-4652(200003)182:3%3C311::AID-JCP1%3E3.0.CO;2-910653597
21.	SY JungW HanJW LeeKi-67 expression gives additional prognostic information on St. Gallen 2007 and Adjuvant! Online risk categories in early breast cancerAnn Surg Oncol1611121121200919219507
22.	TN MoyanaJ XiangA SenthilselvanA KulagaThe spectrum of neuroendocrine differentiation among gastrointestinal carcinoids: importance of histologic grading, MIB-1, p53, and bcl-2 immunoreactivityArch Pathol Lab Med1245705762000
23.	C SokmensuerG GedikogluB UzunalimogluImportance of proliferation markers in gastrointestinal carcinoid tumors: a clinicopathologic studyHepatogastroenterology48720723200111462912
24.	Y OkumuraM MarutaK MaedaMinute carcinoid tumor in the rectum with liver metastasisGan To Kagaku Ryoho24Suppl 23073121997(In Japanese)
25.	H ScherüblRectal carcinoids are on the rise: early detection by screening endoscopyEndoscopy41162165200919214898
26.	SM HeahKW EuBS OoiYH HoF Seow-ChoenTumor size is irrelevant in predicting malignant potential of carcinoid tumors of the rectumTech Coloproctol57377200110.1007/s10151017000211862561
27.	B StinnerO KiskerA ZielkeM RothmundSurgical management for carcinoid tumors of small bowel, appendix, colon, and rectumWorld J Surg20183188199610.1007/s0026899000288661815
28.	JK RamagePE GoretzkiR ManfrediConsensus Conference participants: Consensus guidelines for the management of patients with digestive neuroendocrine tumours: well-differentiated colon and rectum tumour/carcinomaNeuroendocrinology873139200810.1159/000111036
29.	AN KouraGG GiaccoSA CurleyJM SkibberBW FeigLM EllisCarcinoid tumors of the rectum: effect of size, histopathology, and surgical treatment on metastasis free survivalCancer7912941298199710.1002/(SICI)1097-0142(19970401)79:7%3C1294::AID-CNCR4%3E3.0.CO;2-H9083149
30.	Y MashimoT MatsudaT UraokaEndoscopic submucosal resection with a ligation device is an effective and safe treatment for carcinoid tumors in the lower rectumJ Gastroenterol Hepatol23218221200810.1111/j.1440-1746.2008.05313.x18289355
31.	T ShinoharaK HottaT OyamaRectal carcinoid tumor, 6 mm in diameter, with lymph node metastasesEndoscopy40Suppl 2E40E41200810.1055/s-2007-96684918302079
32.	SH MoonJH HwangDK SohnEndoscopic submucosal dissection for rectal neuroendocrine (carcinoid) tumorsJ Laparoendosc Adv Surg Tech A21695699201110.1089/lap.2011.006821657940

Journals

International Journal of Molecular Medicine

International Journal of Oncology

Molecular Medicine Reports

Oncology Reports

Experimental and Therapeutic Medicine

Oncology Letters

Biomedical Reports

Molecular and Clinical Oncology

World Academy of Sciences Journal

International Journal of Functional Nutrition

International Journal of Epigenetics

Medicine International

Clinicopathological characteristics of rectal carcinoid patients undergoing surgical resection

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