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Print ISSN: 1792-1074 Online ISSN: 1792-1082
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November 2012 Volume 4 Issue 5

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International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

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Review

Mitochondrial DNA mutations in human tumor cells (Review)

  • Authors:
    • Hui Li
    • Ze-Hui Hong
  • View Affiliations / Copyright

    Affiliations: Department of Genetics and Developmental Biology, Southeast University School of Medicine, Nanjing, Jiangsu 210009, P.R. China, The Key Laboratory of Developmental Genes and Human Disease, Ministry of Education, Southeast University, Nanjing, Jiangsu 210009, P.R. China
  • Pages: 868-872
    |
    Published online on: August 23, 2012
       https://doi.org/10.3892/ol.2012.874
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Abstract

Mitochondria play significant roles in cellular energy metabolism, free radical generation and apoptosis. The dysfunction of mitochondria is correlated with the origin and progression of tumors; thus, mutations in the mitochondrial genome that affect mitochondrial function may be one of the causal factors of tumorigenesis. Although the role of mitochondrial DNA (mtDNA) mutations in carcinogenesis has been investigated extensively by various approaches, the conclusions remain controversial to date. This review briefly summarizes the recent progress in this field.
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Copy and paste a formatted citation
Spandidos Publications style
Li H and Hong Z: Mitochondrial DNA mutations in human tumor cells (Review). Oncol Lett 4: 868-872, 2012.
APA
Li, H., & Hong, Z. (2012). Mitochondrial DNA mutations in human tumor cells (Review). Oncology Letters, 4, 868-872. https://doi.org/10.3892/ol.2012.874
MLA
Li, H., Hong, Z."Mitochondrial DNA mutations in human tumor cells (Review)". Oncology Letters 4.5 (2012): 868-872.
Chicago
Li, H., Hong, Z."Mitochondrial DNA mutations in human tumor cells (Review)". Oncology Letters 4, no. 5 (2012): 868-872. https://doi.org/10.3892/ol.2012.874
Copy and paste a formatted citation
x
Spandidos Publications style
Li H and Hong Z: Mitochondrial DNA mutations in human tumor cells (Review). Oncol Lett 4: 868-872, 2012.
APA
Li, H., & Hong, Z. (2012). Mitochondrial DNA mutations in human tumor cells (Review). Oncology Letters, 4, 868-872. https://doi.org/10.3892/ol.2012.874
MLA
Li, H., Hong, Z."Mitochondrial DNA mutations in human tumor cells (Review)". Oncology Letters 4.5 (2012): 868-872.
Chicago
Li, H., Hong, Z."Mitochondrial DNA mutations in human tumor cells (Review)". Oncology Letters 4, no. 5 (2012): 868-872. https://doi.org/10.3892/ol.2012.874
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