Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Oncology Letters
Join Editorial Board Propose a Special Issue
Print ISSN: 1792-1074 Online ISSN: 1792-1082
Journal Cover
November 2012 Volume 4 Issue 5

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
November 2012 Volume 4 Issue 5

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article

Dermatofibrosarcoma protuberans: Our experience of 59 cases

  • Authors:
    • Alessio Stivala
    • Giuseppe A.G. Lombardo
    • Gianluca Pompili
    • Maria Stella Tarico
    • Filippo Fraggetta
    • Rosario Emanuele Perrotta
  • View Affiliations / Copyright

    Affiliations: Department of Medical and Surgery Specialties, Section of Plastic Surgery, University of Catania, Cannizzaro Hospital, I-95126 Catania, Italy, Department of Medical and Surgery Specialties, Section of Plastic Surgery, University of Catania, Cannizzaro Hospital, I-95126 Catania, Italy , Department of Pathological Anatomy, University of Catania, Cannizzaro Hospital, I-95126 Catania, Italy
  • Pages: 1047-1055
    |
    Published online on: August 30, 2012
       https://doi.org/10.3892/ol.2012.887
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

Dermatofibrosarcoma protuberans (DFSP) is a rare soft tissue tumor with intermediate malignancy. It is initially located on the skin from where it is able to infiltrate the deep structures and has a tendency to recur locally following inadequate excision. A t(17;22)(q22;q13) chromosome translocation is the main cytogenetic alteration responsible for the onset of DFSP. Treatment options include complete surgical excision by performing conventional surgery with wide margins (>3 cm) or Mohs micrographic surgery. A retrospective study was conducted in our Department of Plastic and Reconstructive Surgery and all data were collected from medical records of 59 DFSP patients within this department from 1999 to 2011. A total of 13 of 59 (22%) cases were treated with conventional excision; 3 (5%) cases resulted in tumor-free margins, 8 (14%) cases required surgical revision and 2 (3%) cases lead to recurrence. A total of 46 of 59 (78%) cases were treated with wide excision; 43 (73%) cases resulted in tumor-free margins, 3 (5%) cases required surgical revision and 0 (0%) cases lead to recurrence. In conclusion, the data collected reveal the controversy surrounding the adoption of general guidelines regarding safe margins. Further studies are required to investigate the possibility of obtaining genotypically altered margins from margins that may appear phenotypically healthy.
View Figures
View References

1. 

J DarierM FerrandDermatofibromes progressifs et recidivants ou fibrosarcomes de la peauAnn Dermatol Syphiligr (Paris)55425621924

2. 

E HoffmanUeber das knollentribende fibrosarkom der haut (dermatofibrosarcoma protuberans)Dermatol Z43128192510.1159/000250699

3. 

HB TaylorEB HelwigDermatofibrosarcoma protuberans. A study of 115 casesCancer15717725196210.1002/1097-0142(196207/08)15:4%3C717::AID-CNCR2820150405%3E3.0.CO;2-213919964

4. 

DA AltmanBJ NickoloffDP FivensonDermatofibrosarcoma protuberans strongly express CD34J Cutan Pathol195091992

5. 

P AbenozaT LillemoeCD34 and factor XIIIa in the differential diagnosis of dermatofibroma and dermatofibrosarcoma protuberansAm J Dermatopathol15429434199310.1097/00000372-199310000-000037694515

6. 

MP SimonF PedeutourN SirventJ GrosgeorgeF MinolettiJM CoindreDeregulation of the platelet-derived growth factor B-chain gene via fusion with collagen gene COL1A1 in dermatofibrosarcoma protuberans and giant cell fibroblastomaNat Genet159598199710.1038/ng0197-958988177

7. 

D LemmLO MuggeT MentzelCurrent treatment options in dermatofibrosarcoma protuberansJ Cancer Res Clin Oncol135653665200910.1007/s00432-009-0550-319205737

8. 

B LlombartO SanmartínJ López-GuerreroDermatofibrosarcoma protuberante en la infanciaPiel21435441200610.1016/S0213-9251(06)72532-1

9. 

K Bendix-HansenO Myhre-JensenS KaaeDermatofibrosarcoma protuberans. A clinico-pathological study of nineteen cases and review of world literatureScand J Plast Reconstr Surg17247252198310.3109/028443183090131256673092

10. 

T-Y ChuangWP SuSA MullerIncidence of cutaneous T cell lymphoma and other rare skin tumors in a defined populationJ Am Acad Dermatol23254256199010.1016/0190-9622(90)70208-Y2170468

11. 

EJ RutgersBB KroonCE Albus-LutterE GortzarDermatofibrosarcoma protuberans: treatment and prognosisEur J Surg Oncol1824124819921607035

12. 

VD CriscioneMA WeinstockDescriptive epidemiology of dermatofibrosarcoma protuberans in the United States, 1973 to 2002J Am Acad Dermatol56968973200710.1016/j.jaad.2006.09.00617141362

13. 

O SanmartínB LlombartJA López-GuerreroDermatofibrosarcoma protuberansActas Dermosifiliogr9877872007

14. 

SLM GooskensAP OranjeLNA van AdrichemImatinib mesylate for children with dermatofibrosarcoma protuberansPediatr Blood Cancer55369373201010.1002/pbc.2249420582941

15. 

WE LoveSA KeilerJE TamburroSurgical management of congenital dermatofibrosarcoma protuberansJ Am Acad Dermatol6110141023200910.1016/j.jaad.2009.05.02819925926

16. 

G AnnessiA CimitanG GirolomoniA DiSilveiroCongenital dermatofibrosarcoma protuberansPediatr Dermatol104042199310.1111/j.1525-1470.1993.tb00011.x

17. 

PH McKeeCD FletcherDermatofibrosarcoma protuberans presenting in infancy and childhoodJ Cutan Pathol18241246199110.1111/j.1600-0560.1991.tb01230.x1939782

18. 

SR CheckettsTK HamiltonRD BaughmanCongenital and childhood dermatofibrosarcoma protuberans: a case report and review of the literatureJ Am Acad Dermatol42907913200010.1016/S0190-9622(00)90270-610767703

19. 

L MartinP CombemaleM DupinB ChouvetJ KanitakisML Bouyssou-GauthierThe atrophic variant of dermatofibrosarcoma protuberans in childhood: a report of six casesBr J Dermatol139719725199810025975

20. 

CD FletcherGiant cell fibroblastoma of soft tissue: a clinicopathological and immunohistochemical studyHistopathology13499508198810.1111/j.1365-2559.1988.tb02074.x3215632

21. 

MP MbondeH AmirJN KitinyaDermatofibrosarcoma protuberans: a clinicopathological study in an African populationEast Afr Med J7341041319968840606

22. 

ME BasharaKT JulesGK PotterDermatofibrosarcoma protuberans: 4 years after local traumaJ Foot Surg3116016519921353770

23. 

A TanakaM HatokoH TadaM KuwaharaH IiokaK NiitsumaDermatofibrosarcoma protuberans arising from a burn scar of the axillaAnn Plast Surg52423425200410.1097/01.sap.0000100421.95683.9b15084891

24. 

A ArgirisC DardoufasK AroniRadiotherapy induced soft tissue sarcoma: an unusual case of a dermatofibrosarcoma protuberansClin Oncol (R Coll Radiol)75961199510.1016/S0936-6555(05)80641-77727312

25. 

JJ GreenWR HeymannDermatofibrosarcoma protuberans occurring in a smallpox vaccination scarJ Am Acad Dermatol48S54S55200310.1067/mjd.2003.16812734474

26. 

I BukhariO Al AklobyY BedaiwiDermatofibrosarcoma protuberans at the site of a central venous line. Case reportAm J Clin Dermatol66164200510.2165/00128071-200506010-0000715675891

27. 

LM LehmerBD RagsdaleDigital dermatofibromas -common lesion, uncommon location: a series of 26 cases and review of the literatureDermatol Online J172201121906482

28. 

L MartinF PietteP BlancL MortierMF AvrilMM DelaunayClinical variants of the preprotuberant stage of dermatofibrosarcoma protuberansBr J Dermatol153932936200510.1111/j.1365-2133.2005.06823.x16225602

29. 

GK KimStatus report on the management of dermatofibrosarcoma protuberans: is there a viable role for the use of imatinib mesylate? In which cases may it be therapeutically helpful and in which cases not?J Clin Aesthet Dermatol417262011

30. 

H KaminoM JacobsonDermatofibroma extending into the subcutaneous tissue. Differential diagnosis from dermatofibrosarcoma protuberansAm J Surg Pathol1411561164199010.1097/00000478-199012000-000082252106

31. 

BW ZelgerD OfnerBG ZelgerAtrophic variants of dermatofibroma and dermatofibrosarcoma protuberansHistopathology26519527199510.1111/j.1365-2559.1995.tb00270.x7545142

32. 

S AibaN TabataH IshiiH OotamiH TagamiDermatofibrosarcoma protuberans is a unique fibrohistiocytic tumour expressing CD34Br J Dermatol1277984199210.1111/j.1365-2133.1992.tb08036.x1382538

33. 

H KutznerExpression of the human progenitor cell antigen CD34 (HPCA-1) distinguishes dermatofibrosarcoma protuberans from fibrous histiocytoma in formalin-fixed, paraffin-embedded tissueJ Am Acad Dermatol28613617199310.1016/0190-9622(93)70083-6

34. 

SE CowperT KilpatrickS ProperMB MorganSolitary fibrous tumor of the skinAm J Dermatopathol21213219199910.1097/00000372-199906000-00001

35. 

VN HanftCR SheaNS McNuttD PullitzerMG HorensteinVG PrietoExpression of CD34 in sclerotic (‘plywood’) fibromasAm J Dermatopathol2217212000

36. 

JF FetschWB LaskinM MiettinenSuperficial acral fibromyxoma: a clinicopathologic and immunohistochemical analysis of 37 cases of a distinctive soft tissue tumor with a predilection for the fingers and toesHum Pathol32704714200110.1053/hupa.2001.2590311486169

37. 

JM McNiffA SubtilSE CowperR LazovaEJ GlusacCellular digital fibromas: distinctive CD34-positive lesions that may mimic dermatofibrosarcoma protuberansJ Cutan Pathol32413418200510.1111/j.0303-6987.2005.00358.x15953374

38. 

R SachdevU SundramExpression of CD163 in dermatofibroma, cellular fibrous histiocytoma, and dermatofibrosarcoma protuberans: comparison with CD68, CD34, and Factor XIIIaJ Cutan Pathol33353360200610.1111/j.0303-6987.2006.00439.x16640542

39. 

AH DiwanMG HorensteinDermatofibrosarcoma protuberans association with nuchal-type fibromaJ Cutan Pathol316266200410.1046/j.0303-6987.2004.0129.x14675287

40. 

B CribierG NoaccoB PeltreE GrosshansStromelysin 3 expression: a useful marker for the differential diagnosis dermatofibroma versus dermatofibrosarcoma protuberansJ Am Acad Dermatol46408413200210.1067/mjd.2002.119656

41. 

RB WestJ HarvellSC LinnCL LiuW PrapongT Hernández BoussardApo D in soft tissue tumors: a novel marker for dermatofibrosarcoma protuberansAm J Surg Pathol2810631069200410.1097/01.pas.0000126857.86186.4c15252314

42. 

B BandarchiL MaC MargineanD2-40, a novel immunohistochemical marker in differentiating dermatofibroma from dermatofibrosarcoma protuberansMod Pathol23434438201010.1038/modpathol.2009.176

43. 

F PedeutourMP SimonF MinolettiG SozziMA PierottiF HechtRing 22 chromosomes in dermatofibrosarcoma protuberans are low-level amplifiers of chromosome 17 and 22 sequencesCancer Res552400240319957757993

44. 

MJ Terrier-LacombeL GuillouG MaireP TerrierDR VinceAubain de SaintN SomerhausenDermatofibrosarcoma protuberans, giant cell fibroblastoma, and hybrid lesions in children: clinicopathologic comparative analysis of 28 cases with molecular data - a study from the French Federation of Cancer Centers Sarcoma GroupAm J Surg Pathol272739200310.1097/00000478-200301000-00004

45. 

A ShimizuKP O'BrienT SjoblomK PietrasE BuchdungerVP CollinsThe dermatofibrosarcoma protuberans associated collagen type Ialpha1/platelet-derived growth factor (PDGF) B-chain fusion gene generates a transforming protein that is processed to functional PDGFBBCancer Res59371937231999

46. 

CK ChangIA JacobsGI SaltiOutcomes of surgery for dermatofibrosarcoma protuberansEur J Surg Oncol30341345200410.1016/j.ejso.2003.12.005

47. 

M FioreR MiceliC MussiS Lo VulloL MarianiL LozzaDermatofibrosarcoma protuberans treated at a single institution: a surgical disease with a high cure rateJ Clin Oncol2376697675200510.1200/JCO.2005.02.512216234529

48. 

HM Gloster JrKR HarrisRK RoenigkA comparison between Mohs micrographic surgery and wide surgical excision for the treatment of dermatofibrosarcoma protuberansJ Am Acad Dermatol35828719968682970

49. 

KC Dim-JamoraJB PeroneManagement of cutaneous tumors with Mohs micrographic surgerySemin Plast Surg22247256200810.1055/s-0028-109588420567701

50. 

DR GuillenCJ CockerellCutaneous and subcutaneous sarcomasClin Dermatol19262268200110.1016/S0738-081X(01)00177-811479038

51. 

L LossNC ZeitouniManagement of scalp dermatofibrosarcoma protuberansDermatol Surg3114281433200516416612

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Stivala A, Lombardo GA, Pompili G, Tarico MS, Fraggetta F and Perrotta RE: Dermatofibrosarcoma protuberans: Our experience of 59 cases. Oncol Lett 4: 1047-1055, 2012.
APA
Stivala, A., Lombardo, G.A., Pompili, G., Tarico, M.S., Fraggetta, F., & Perrotta, R.E. (2012). Dermatofibrosarcoma protuberans: Our experience of 59 cases. Oncology Letters, 4, 1047-1055. https://doi.org/10.3892/ol.2012.887
MLA
Stivala, A., Lombardo, G. A., Pompili, G., Tarico, M. S., Fraggetta, F., Perrotta, R. E."Dermatofibrosarcoma protuberans: Our experience of 59 cases". Oncology Letters 4.5 (2012): 1047-1055.
Chicago
Stivala, A., Lombardo, G. A., Pompili, G., Tarico, M. S., Fraggetta, F., Perrotta, R. E."Dermatofibrosarcoma protuberans: Our experience of 59 cases". Oncology Letters 4, no. 5 (2012): 1047-1055. https://doi.org/10.3892/ol.2012.887
Copy and paste a formatted citation
x
Spandidos Publications style
Stivala A, Lombardo GA, Pompili G, Tarico MS, Fraggetta F and Perrotta RE: Dermatofibrosarcoma protuberans: Our experience of 59 cases. Oncol Lett 4: 1047-1055, 2012.
APA
Stivala, A., Lombardo, G.A., Pompili, G., Tarico, M.S., Fraggetta, F., & Perrotta, R.E. (2012). Dermatofibrosarcoma protuberans: Our experience of 59 cases. Oncology Letters, 4, 1047-1055. https://doi.org/10.3892/ol.2012.887
MLA
Stivala, A., Lombardo, G. A., Pompili, G., Tarico, M. S., Fraggetta, F., Perrotta, R. E."Dermatofibrosarcoma protuberans: Our experience of 59 cases". Oncology Letters 4.5 (2012): 1047-1055.
Chicago
Stivala, A., Lombardo, G. A., Pompili, G., Tarico, M. S., Fraggetta, F., Perrotta, R. E."Dermatofibrosarcoma protuberans: Our experience of 59 cases". Oncology Letters 4, no. 5 (2012): 1047-1055. https://doi.org/10.3892/ol.2012.887
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team