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December 2012 Volume 4 Issue 6

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International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

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Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

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Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

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Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

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Article

Assessement of angiogenesis reveals blood vessel heterogeneity in lung carcinoma

  • Authors:
    • Amalia Birau
    • Raluca Amalia Ceausu
    • Anca Maria Cimpean
    • Pusa Gaje
    • Marius Raica
    • Teodora Olariu
  • View Affiliations / Copyright

    Affiliations: Department of Intensive Care, ‘Vasile Goldis’ Western University of Arad, Arad, Arad 310396, Romania, Department of Histology, ‘Victor Babeș’ University of Medicine and Pharmacy, Angiogenesis Research Center, Timisoara, Timis 300041, Romania
  • Pages: 1183-1186
    |
    Published online on: September 5, 2012
       https://doi.org/10.3892/ol.2012.893
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Abstract

Despite advances in treatment, the prognosis for lung cancer patients remains poor. Angiogenesis appears to be a promising target for lung cancer therapy; however, the clinical significance of vascular changes are not completely understood. The aim of this study was to evaluate the types and morphology of blood vessels in various lung carcinomas. Using double immunostaining, we investigated 39 biopsies from patients admitted with various histological types of lung carcinoma. Tumor blood vessels were quantified separately for CD34/smooth muscle actin and described as either immature, intermediate or mature. Double immunostaining evaluation of the type of blood vessels in lung carcinomas revealed a marked heterogeneity. The immature and intermediate type of vessels were more common in adenocarcinomas (ADCs) and squamous cell carcinomas (SCCs) of the lung. Small cell lung carcinomas revealed a significant correlation between pathological and immature types of blood vessels. Therefore, quantifying the types of tumor vessels in lung carcinomas may be an important element to improve the results of anti‑vascular therapy.
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Copy and paste a formatted citation
Spandidos Publications style
Birau A, Ceausu RA, Cimpean AM, Gaje P, Raica M and Olariu T: Assessement of angiogenesis reveals blood vessel heterogeneity in lung carcinoma. Oncol Lett 4: 1183-1186, 2012.
APA
Birau, A., Ceausu, R.A., Cimpean, A.M., Gaje, P., Raica, M., & Olariu, T. (2012). Assessement of angiogenesis reveals blood vessel heterogeneity in lung carcinoma. Oncology Letters, 4, 1183-1186. https://doi.org/10.3892/ol.2012.893
MLA
Birau, A., Ceausu, R. A., Cimpean, A. M., Gaje, P., Raica, M., Olariu, T."Assessement of angiogenesis reveals blood vessel heterogeneity in lung carcinoma". Oncology Letters 4.6 (2012): 1183-1186.
Chicago
Birau, A., Ceausu, R. A., Cimpean, A. M., Gaje, P., Raica, M., Olariu, T."Assessement of angiogenesis reveals blood vessel heterogeneity in lung carcinoma". Oncology Letters 4, no. 6 (2012): 1183-1186. https://doi.org/10.3892/ol.2012.893
Copy and paste a formatted citation
x
Spandidos Publications style
Birau A, Ceausu RA, Cimpean AM, Gaje P, Raica M and Olariu T: Assessement of angiogenesis reveals blood vessel heterogeneity in lung carcinoma. Oncol Lett 4: 1183-1186, 2012.
APA
Birau, A., Ceausu, R.A., Cimpean, A.M., Gaje, P., Raica, M., & Olariu, T. (2012). Assessement of angiogenesis reveals blood vessel heterogeneity in lung carcinoma. Oncology Letters, 4, 1183-1186. https://doi.org/10.3892/ol.2012.893
MLA
Birau, A., Ceausu, R. A., Cimpean, A. M., Gaje, P., Raica, M., Olariu, T."Assessement of angiogenesis reveals blood vessel heterogeneity in lung carcinoma". Oncology Letters 4.6 (2012): 1183-1186.
Chicago
Birau, A., Ceausu, R. A., Cimpean, A. M., Gaje, P., Raica, M., Olariu, T."Assessement of angiogenesis reveals blood vessel heterogeneity in lung carcinoma". Oncology Letters 4, no. 6 (2012): 1183-1186. https://doi.org/10.3892/ol.2012.893
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