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Article

Bak is a key molecule in apoptosis induced by methanol extracts of Codonopsis lanceolata and Tricholoma matsutake in HSC-2 human oral cancer cells

  • Authors:
    • Ji-Ae Shin
    • Jun Sung Kim
    • In-Sun Hong
    • Sung-Dae Cho
  • View Affiliations / Copyright

    Affiliations: Department of Oral Pathology, School of Dentistry, Institute of Oral Bioscience, Chonbuk National University, Jeonju, Republic of Korea, R__AMB__D Center, Biterials Co. Ltd., Seoul, Republic of Korea, Department of Veterinary Public Health, Laboratory of Stem Cell and Tumor Biology, Seoul National University, Seoul, Republic of Korea
  • Pages: 1379-1383
    |
    Published online on: September 6, 2012
       https://doi.org/10.3892/ol.2012.898
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Abstract

Since the 5-year survival rate of oral cancer remains low, more effective and non-toxic therapeutic and preventive strategies are required. Certain natural products possess anticancer properties. The present study investigated the effects of the methanol extracts of Codonopsis lanceolata (MECI) and Tricholoma matsutake (METM) and identified the molecular target in HSC-2 human oral cancer cells. The results revealed that MECI and METM inhibited growth and induced apoptosis, as demonstrated by poly (ADP-ribose) polymerase (PARP) cleavage and nuclear condensation and fragmentation. The compounds also increased Bak protein expression, while Bax, Bcl-XL and Mcl-1 were not affected. The results of the present study show that MECI and METM induce apoptosis to inhibit tumor growth of HSC-2 cells by modulating the Bak protein and suggest that Codonopsis lanceolata and Tricholoma matsutake are potential anticancer drug candidates for oral cancer.
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Copy and paste a formatted citation
Spandidos Publications style
Shin J, Kim JS, Hong I and Cho S: Bak is a key molecule in apoptosis induced by methanol extracts of Codonopsis lanceolata and Tricholoma matsutake in HSC-2 human oral cancer cells. Oncol Lett 4: 1379-1383, 2012.
APA
Shin, J., Kim, J.S., Hong, I., & Cho, S. (2012). Bak is a key molecule in apoptosis induced by methanol extracts of Codonopsis lanceolata and Tricholoma matsutake in HSC-2 human oral cancer cells. Oncology Letters, 4, 1379-1383. https://doi.org/10.3892/ol.2012.898
MLA
Shin, J., Kim, J. S., Hong, I., Cho, S."Bak is a key molecule in apoptosis induced by methanol extracts of Codonopsis lanceolata and Tricholoma matsutake in HSC-2 human oral cancer cells". Oncology Letters 4.6 (2012): 1379-1383.
Chicago
Shin, J., Kim, J. S., Hong, I., Cho, S."Bak is a key molecule in apoptosis induced by methanol extracts of Codonopsis lanceolata and Tricholoma matsutake in HSC-2 human oral cancer cells". Oncology Letters 4, no. 6 (2012): 1379-1383. https://doi.org/10.3892/ol.2012.898
Copy and paste a formatted citation
x
Spandidos Publications style
Shin J, Kim JS, Hong I and Cho S: Bak is a key molecule in apoptosis induced by methanol extracts of Codonopsis lanceolata and Tricholoma matsutake in HSC-2 human oral cancer cells. Oncol Lett 4: 1379-1383, 2012.
APA
Shin, J., Kim, J.S., Hong, I., & Cho, S. (2012). Bak is a key molecule in apoptosis induced by methanol extracts of Codonopsis lanceolata and Tricholoma matsutake in HSC-2 human oral cancer cells. Oncology Letters, 4, 1379-1383. https://doi.org/10.3892/ol.2012.898
MLA
Shin, J., Kim, J. S., Hong, I., Cho, S."Bak is a key molecule in apoptosis induced by methanol extracts of Codonopsis lanceolata and Tricholoma matsutake in HSC-2 human oral cancer cells". Oncology Letters 4.6 (2012): 1379-1383.
Chicago
Shin, J., Kim, J. S., Hong, I., Cho, S."Bak is a key molecule in apoptosis induced by methanol extracts of Codonopsis lanceolata and Tricholoma matsutake in HSC-2 human oral cancer cells". Oncology Letters 4, no. 6 (2012): 1379-1383. https://doi.org/10.3892/ol.2012.898
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