Bak is a key molecule in apoptosis induced by methanol extracts of Codonopsis lanceolata and Tricholoma matsutake in HSC-2 human oral cancer cells

  • Authors:
    • Ji-Ae Shin
    • Jun Sung Kim
    • In-Sun Hong
    • Sung-Dae Cho
  • View Affiliations

  • Published online on: September 6, 2012     https://doi.org/10.3892/ol.2012.898
  • Pages: 1379-1383
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Abstract

Since the 5-year survival rate of oral cancer remains low, more effective and non-toxic therapeutic and preventive strategies are required. Certain natural products possess anticancer properties. The present study investigated the effects of the methanol extracts of Codonopsis lanceolata (MECI) and Tricholoma matsutake (METM) and identified the molecular target in HSC-2 human oral cancer cells. The results revealed that MECI and METM inhibited growth and induced apoptosis, as demonstrated by poly (ADP-ribose) polymerase (PARP) cleavage and nuclear condensation and fragmentation. The compounds also increased Bak protein expression, while Bax, Bcl-XL and Mcl-1 were not affected. The results of the present study show that MECI and METM induce apoptosis to inhibit tumor growth of HSC-2 cells by modulating the Bak protein and suggest that Codonopsis lanceolata and Tricholoma matsutake are potential anticancer drug candidates for oral cancer.
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December 2012
Volume 4 Issue 6

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Spandidos Publications style
Shin J, Kim JS, Hong I and Cho S: Bak is a key molecule in apoptosis induced by methanol extracts of Codonopsis lanceolata and Tricholoma matsutake in HSC-2 human oral cancer cells. Oncol Lett 4: 1379-1383, 2012
APA
Shin, J., Kim, J.S., Hong, I., & Cho, S. (2012). Bak is a key molecule in apoptosis induced by methanol extracts of Codonopsis lanceolata and Tricholoma matsutake in HSC-2 human oral cancer cells. Oncology Letters, 4, 1379-1383. https://doi.org/10.3892/ol.2012.898
MLA
Shin, J., Kim, J. S., Hong, I., Cho, S."Bak is a key molecule in apoptosis induced by methanol extracts of Codonopsis lanceolata and Tricholoma matsutake in HSC-2 human oral cancer cells". Oncology Letters 4.6 (2012): 1379-1383.
Chicago
Shin, J., Kim, J. S., Hong, I., Cho, S."Bak is a key molecule in apoptosis induced by methanol extracts of Codonopsis lanceolata and Tricholoma matsutake in HSC-2 human oral cancer cells". Oncology Letters 4, no. 6 (2012): 1379-1383. https://doi.org/10.3892/ol.2012.898