Clear cell neuroendocrine tumor G1 of the gallbladder without von Hippel-Lindau disease

Ishida,Mitsuaki; Shiomi,Hisanori; Naka,Shigeyuki; Tani,Tohru; Okabe,Hidetoshi

doi:10.3892/ol.2012.899

December 2012 Volume 4 Issue 6

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December 2012 Volume 4 Issue 6

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Article

Clear cell neuroendocrine tumor G1 of the gallbladder without von Hippel-Lindau disease

Authors:
- Mitsuaki Ishida
- Hisanori Shiomi
- Shigeyuki Naka
- Tohru Tani
- Hidetoshi Okabe
View Affiliations / Copyright

Affiliations: Department of Clinical Laboratory Medicine and Division of Diagnostic Pathology, Shiga University of Medical Science, Otsu, Shiga 520-2192, Japan, Department of Surgery, Shiga University of Medical Science, Otsu, Shiga 520-2192, Japan
Pages: 1174-1176
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Published online on: September 6, 2012

https://doi.org/10.3892/ol.2012.899
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Abstract

Clear cell neuroendocrine tumor (NET) is a rare but distinct histopathological variant of NET most often observed in patients with von Hippel-Lindau disease (VHL). Clear cell NET in non-VHL patients is extremely rare and this report is only the second to describe a case of clear cell NET G1 (carcinoid tumor) of the gallbladder without VHL. A 71-year‑old male without past or family history of VHL presented with a polypoid lesion in the fundus of the gallbladder and laparoscopic cholecystectomy was performed. Histopathological study revealed that the polypoid lesion was comprised of nests or trabecular growths of clear cells without atypia. Immunohistochemically, the neoplastic cells were diffusely positive for endocrine markers, but negative for α-inhibin. Clinicopathological review of cases with clear cell NET G1 of the gallbladder revealed that this disease occurs in patients with or without VHL, but that gallbladder stones and cholecystitis were present in non-VHL cases. We hypothesized that the occurrence of clear cell NET of the gallbladder (particularly non-VHL cases) may be associated with chronic cholecystitis induced by gallbladder stones. Moreover, α-inhibin was detected in clear cell NET tumor cells in one VHL case, but not in two non-VHL cases. These findings suggest that α-inhibin expression is a useful determinant of an association between clear cell NET and VHL.

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1.	S MassironiV SciolaM PeracchiC CiafardiniMP SpampattiD ConteNeuroendocrine tumors of the gastro-entero-pancreatic systemWorld J Gastroenterol1453775384200810.3748/wjg.14.537718803349
2.	P KomminothR ArnoldC CapellaNeuroendocrine neoplasms of the gallbladder and extrahepatic bile ductsWHO Classification of Tumours of the Digestive SystemFT BosmanF CarneiroRH HrubanND TheiseIARC PressLyon2742762010
3.	KM EltawilBI GustafssonM KiddIM ModlinNeuroendocrine tumors of the gallbladder: an evaluation and reassessment of management strategyJ Clin Gastroenterol44687695201020375728
4.	V AnjaneyuluG Shankar-SwarnalathaSC RaoCarcinoid tumor of the gall bladderAnn Diagn Pathol11113116200710.1016/j.anndiagpath.2005.12.00317349570
5.	MP HoangRH HrubanJ Albores-SaavedraClear cell endocrine pancreatic tumor mimicking renal cell carcinoma: a distinctive neoplasm of von Hippel-Lindau diseaseAm J Surg Pathol25602609200110.1097/00000478-200105000-0000611342771
6.	S NunobeN FukushimaS YachidaK ShimadaT KosugeM SakamotoClear cell endocrine tumor of the pancreas which is not associated with von Hippel-Lindau disease: report of a caseSurg Today33470474200310.1007/s10595-002-2508-x12768377
7.	PA SinkreL MurakataL RabinMP HoangJ Albores-SaavedraClear cell carcinoid tumor of the gallbladder: another distinctive manifestation of von Hippel-Lindau diseaseAm J Surg Pathol2513341339200110.1097/00000478-200110000-0001711688471
8.	E KonishiY NakashimaTC SmyrkS MasudaClear cell carcinoid tumor of the gallbladder. A case without von Hippel-Lindau diseaseArch Pathol Lab Med127745747200312741904
9.	J Albores-SaavedraM NadjiDE HensonJ Ziegels-WeissmanJM MonesIntestinal metaplasia of the gallbladder: a morphologic and immunocytochemical studyHum Pathol17614620198610.1016/S0046-8177(86)80134-42872152
10.	M YamamotoS NakajoN MiyoshiS NakaiE TaharaEndocrine cell carcinoma (carcinoid) of the gallbladderAm J Surg Pathol13292302198910.1097/00000478-198904000-000042648878
11.	H SakamotoH MutohK IdoK SatohH HayakawaK SuganoA close relationship between intestinal metaplasia and Cdx2 expression in human gallbladders with cholelithiasisHum Pathol386671200710.1016/j.humpath.2006.06.01016996572
12.	A MaitraM TascilarRH HrubanGJ OfferhausJ Albores-SaavedraSmall cell carcinoma of the gallbladder: a clinicopathologic, immunohistochemical, and molecular pathology study of 12 casesAm J Surg Pathol25595601200110.1097/00000478-200105000-0000511342770
13.	M IshidaR KushimaT ChanoH OkabeImmunohistochemical demonstration of the type III intermediate filament peripherin in human rectal mucosae and well-differentiated endocrine neoplasmsOncol Rep186336372007
14.	M IshidaR KushimaM BrevetD ChatelainH OkabeCo-expression of neuronal intermediate filaments, peripherin and α-internexin in human well-differentiated endocrine neoplasms (carcinoid tumors) of the appendixMol Med Report11911952008

Journals

International Journal of Molecular Medicine

International Journal of Oncology

Molecular Medicine Reports

Oncology Reports

Experimental and Therapeutic Medicine

Oncology Letters

Biomedical Reports

Molecular and Clinical Oncology

World Academy of Sciences Journal

International Journal of Functional Nutrition

International Journal of Epigenetics

Medicine International

Clear cell neuroendocrine tumor G1 of the gallbladder without von Hippel-Lindau disease

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