Hand-foot syndrome in a patient with metastatic lung adenocarcinoma induced by high-dose icotinib: A case report and review of the literature

  • Authors:
    • Yulong Zheng
    • Weijia Fang
    • Nong Xu
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  • Published online on: September 10, 2012     https://doi.org/10.3892/ol.2012.904
  • Pages: 1341-1343
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Abstract

Icotinib is a new oral epidermal growth factor tyrosine kinase inhibitor (EGFR-TKI). The most frequent side-effects of icotinib include rash and diarrhea. Hand-foot syndrome (HFS) induced by EGFR-TKI is rare. The present study describes, for the first time, HFS induced by high‑dose icotinib in a 65-year old female with metastatic lung adenocarcinoma. The patient developed HFS during the first week of icotinib treatment with characteristic clinical presentation. HFS regressed after icotinib dose-reduction was initiated. HFS may occur with icotinib, especially when administered in high doses.
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December 2012
Volume 4 Issue 6

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Spandidos Publications style
Zheng Y, Fang W and Xu N: Hand-foot syndrome in a patient with metastatic lung adenocarcinoma induced by high-dose icotinib: A case report and review of the literature. Oncol Lett 4: 1341-1343, 2012
APA
Zheng, Y., Fang, W., & Xu, N. (2012). Hand-foot syndrome in a patient with metastatic lung adenocarcinoma induced by high-dose icotinib: A case report and review of the literature. Oncology Letters, 4, 1341-1343. https://doi.org/10.3892/ol.2012.904
MLA
Zheng, Y., Fang, W., Xu, N."Hand-foot syndrome in a patient with metastatic lung adenocarcinoma induced by high-dose icotinib: A case report and review of the literature". Oncology Letters 4.6 (2012): 1341-1343.
Chicago
Zheng, Y., Fang, W., Xu, N."Hand-foot syndrome in a patient with metastatic lung adenocarcinoma induced by high-dose icotinib: A case report and review of the literature". Oncology Letters 4, no. 6 (2012): 1341-1343. https://doi.org/10.3892/ol.2012.904