Effect of radiotherapy on expression of hyaluronan and EGFR and presence of mast cells in squamous cell carcinoma of the head and neck

Jonsson,Eva  Lindell; Nylander,Karin; Hallén,Lars; Laurell,Göran

doi:10.3892/ol.2012.907

Effect of radiotherapy on expression of hyaluronan and EGFR and presence of mast cells in squamous cell carcinoma of the head and neck

Authors:
- Eva Lindell Jonsson
- Karin Nylander
- Lars Hallén
- Göran Laurell
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Affiliations: Department of Clinical Sciences, Umeå University, SE-901 85 Umeå, Sweden, Department of Medical Biosciences, Umeå University, SE-901 85 Umeå, Sweden
Published online on: September 11, 2012 https://doi.org/10.3892/ol.2012.907
Pages: 1177-1182

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Abstract

Head and neck squamous cell carcinoma is a common form of cancer, and despite improvements in treatment during the last decades, survival rates have not significantly increased. There is therefore a need to better understand how these tumours and the adjacent tissues react to radiotherapy, the most common type of treatment for this group of tumours. In order to improve this understanding, the expression of hyaluronan (HA) and epidermal growth factor receptor (EGFR) and the presence of mast cells were mapped before and after radiotherapy using immunohistochemistry. The results showed HA and EGFR to have similar expression patterns in tumour tissue and histologically normal squamous epithelium prior to radiotherapy. Following radiotherapy, EGFR increased in histologically normal epithelium. An increased number of mast cells were also observed as a result of radiotherapy. No expression of EGFR was observed in the connective tissue either prior to or following radiotherapy.

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