Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Oncology Letters
Join Editorial Board Propose a Special Issue
Print ISSN: 1792-1074 Online ISSN: 1792-1082
Journal Cover
December 2012 Volume 4 Issue 6

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
December 2012 Volume 4 Issue 6

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article

Downregulation of miR-544 in tissue, but not in serum, is a novel biomarker of malignant transformation in glioma

  • Authors:
    • Ruimin Ma
    • Guojun Zhang
    • Huimin Wang
    • Hong Lv
    • Fang Fang
    • Xixiong Kang
  • View Affiliations / Copyright

    Affiliations: Laboratory Diagnosis Center, Beijing Tiantan Hospital, Capital Medical University, Dongcheng, Beijing 100050, P.R. China, Laboratory Diagnosis Center, Beijing Tiantan Hospital, Capital Medical University, Dongcheng, Beijing 100050, P.R. China, Department of Cadres Health Care, Inner Mongolia People's Hospital, Hohhot, Inner Mongolia 010017, P.R. China
  • Pages: 1321-1324
    |
    Published online on: September 14, 2012
       https://doi.org/10.3892/ol.2012.918
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

Low-grade glioma is predisposed to progress to anaplastic astrocytoma and eventually secondary glioblastoma. The malignant transformation may involve the accumulation of multiple genetic alterations. The purpose of this study was to explore the role of miR-544 in glioma progression and discuss whether it may be a novel biomarker of malignant transformation. The expression of miR-544 was measured in a series of 198 glioma samples (63 low-grade glioma, 44 anaplastic astrocytoma and 91 glioblastoma tumors) using microarrays. Quantitative real-time reverse transcription PCR (qRT-PCR) was used to validate the expression levels of miR-544 in tissue and serum samples in an independent validated cohort (25 low-grade glioma, 21 anaplastic astrocytoma and 20 glioblastoma tumors). A Pearson correlation analysis was performed to examine the correlation between miR-544 levels of tissue and serum samples. Microarrays revealed that the expression levels of miR-544 decreased significantly in anaplastic gliomas (P<0.01) or glioblastoma (P<0.01) compared with low-grade gliomas. In an independent cohort of glioma patients, miR-544 exhibited a progression‑associated downregulation in glioma tumors. The levels of miR-544 in serum samples tended to be lower in anaplastic and glioblastoma patients compared with low-grade gliomas, but with no significant difference. The Pearson correlation analysis revealed a weakly positive correlation between tissue and serum levels of miR-544. These data support a significant role for miR-544 aberration in the malignant transformation of glioma. The downregulation of miR-544 in tissue may be used as a novel biomarker.
View Figures

Figure 1

Figure 2

Figure 3

Figure 4

View References

1. 

O MartinhoS GranjaT JaraquemadaDownregulation of RKIP is associated with poor outcome and malignant progression in gliomasPLoS One7e30769201210.1371/journal.pone.003076922292035

2. 

DN LouisH OhgakiOD WiestlerThe 2007 WHO classification of tumours of the central nervous systemActa Neuropathol11497109200710.1007/s00401-007-0243-417618441

3. 

B MalzkornM WolterF LiesenbergIdentification and functional characterization of microRNAs involved in the malignant progression of gliomasBrain Pathol20539550201010.1111/j.1750-3639.2009.00328.x19775293

4. 

L CastellanoG GiamasJ JacobThe estrogen receptor-alpha-induced microRNA signature regulates itself and its transcriptional responseProc Natl Acad Sci USA1061573215737200910.1073/pnas.0906947106

5. 

W FilipowiczSN BhattacharyyaN SonenbergMechanisms of post-transcriptional regulation by microRNAs: are the answers in sight?Nat Rev Genet9102114200810.1038/nrg229018197166

6. 

Y ZhangA DuttaR AbounaderThe role of microRNAs in glioma initiation and progressionFront Biosci17700712201210.2741/395222201769

7. 

JS McDonaldD MilosevicHV ReddiSK GrebeA Algeciras-SchimnichAnalysis of circulating microRNA: preanalytical and analytical challengesClin Chem57833840201110.1373/clinchem.2010.15719821487102

8. 

Z HuX ChenY ZhaoSerum microRNA signatures identified in a genome-wide serum microRNA expression profiling predict survival of non-small-cell lung cancerJ Clin Oncol2817211726201010.1200/JCO.2009.24.934220194856

9. 

K WatanabeK SatoW BiernatIncidence and timing of p53 mutations during astrocytoma progression in patients with multiple biopsiesClin Cancer Res352353019979815715

10. 

TY JungS JungJH MoonIY KimKS MoonWY JangEarly prognostic factors related to progression and malignant transformation of low-grade gliomasClin Neurol Neurosurg113752757201110.1016/j.clineuro.2011.08.00221889256

11. 

R StuppM ReniG GattaE MazzaC VechtAnaplastic astrocytoma in adultsCrit Rev Oncol Hematol637280200710.1016/j.critrevonc.2007.03.003

12. 

M WellerU MalipieroA AguzziJC ReedA FontanaProtooncogene bcl-2 gene transfer abrogates Fas/APO-1 antibody-mediated apoptosis of human malignant glioma cells and confers resistance to chemotherapeutic drugs and therapeutic irradiationJ Clin Invest9526332643199510.1172/JCI117965

13. 

H OhgakiP KleihuesGenetic pathways to primary and secondary glioblastomaAm J Pathol17014451453200710.2353/ajpath.2007.07001117456751

14. 

FB FurnariT FentonRM BachooMalignant astrocytic glioma: genetics, biology, and paths to treatmentGenes Dev2126832710200710.1101/gad.159670717974913

15. 

RG WeberM SabelJ ReifenbergerCharacterization of genomic alterations associated with glioma progression by comparative genomic hybridizationOncogene1398399419968806688

16. 

SH BignerMR MatthewsBK RasheedMolecular genetic aspects of oligodendrogliomas including analysis by comparative genomic hybridizationAm J Pathol155375386199910.1016/S0002-9440(10)65134-6

17. 

DW ParsonsS JonesX ZhangAn integrated genomic analysis of human glioblastoma multiformeScience32118071812200810.1126/science.116438218772396

18. 

A ContiM AguennouzD La TorremiR-21 and 221 upregulation and miR-181b downregulation in human grade II–IV astrocytic tumorsJ Neurooncol93325332200919159078

19. 

L ShiZ ChengJ Zhanghsa-mir-181a and hsa-mir-181b function as tumor suppressors in human glioma cellsBrain Res1236185193200810.1016/j.brainres.2008.07.08518710654

20. 

C QuintavalleM GarofaloC ZancamiR-221/222 over-expession in human glioblastoma increases invasiveness by targeting the protein phosphate PTPmuOncogene31858868201210.1038/onc.2011.28021743492

21. 

ST LeeK ChuHJ OhLet-7 microRNA inhibits the proliferation of human glioblastoma cellsJ Neurooncol1021924201110.1007/s11060-010-0286-620607356

22. 

SA RaoV SantoshK SomasundaramGenome-wide expression profiling identifies deregulated miRNAs in malignant astrocytomaMod Pathol2314041417201010.1038/modpathol.2010.13520711171

23. 

V ThayanithyAL SarverRV KarthaPerturbation of 14q32 miRNAs-cMYC gene network in osteosarcomaBone50171181201210.1016/j.bone.2011.10.01222037351

24. 

JC BraseM JohannesT SchlommCirculating miRNAs are correlated with tumor progression in prostate cancerInt J Cancer128608616201110.1002/ijc.2537620473869

25. 

EK NgWW ChongH JinDifferential expression of microRNAs in plasma of patients with colorectal cancer: a potential marker for colorectal cancer screeningGut5813751381200910.1136/gut.2008.16781719201770

26. 

CC YangPS HungPW WangmiR-181 as a putative biomarker for lymph-node metastasis of oral squamous cell carcinomaJ Oral Pathol Med40397404201110.1111/j.1600-0714.2010.01003.x21244495

27. 

LM WulfkenR MoritzC OhlmannMicroRNAs in renal cell carcinoma: diagnostic implications of serum miR-1233 levelsPLoS One6e25787201110.1371/journal.pone.002578721984948

28. 

L PigatiSC YaddanapudiR IyengarSelective release of microRNA species from normal and malignant mammary epithelial cellsPLoS One5e13515201010.1371/journal.pone.001351520976003

29. 

K ZenCY ZhangCirculating MicroRNAs: a novel class of biomarkers to diagnose and monitor human cancersMed Res Rev32326348201210.1002/med.2021522383180

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Ma R, Zhang G, Wang H, Lv H, Fang F and Kang X: Downregulation of miR-544 in tissue, but not in serum, is a novel biomarker of malignant transformation in glioma. Oncol Lett 4: 1321-1324, 2012.
APA
Ma, R., Zhang, G., Wang, H., Lv, H., Fang, F., & Kang, X. (2012). Downregulation of miR-544 in tissue, but not in serum, is a novel biomarker of malignant transformation in glioma. Oncology Letters, 4, 1321-1324. https://doi.org/10.3892/ol.2012.918
MLA
Ma, R., Zhang, G., Wang, H., Lv, H., Fang, F., Kang, X."Downregulation of miR-544 in tissue, but not in serum, is a novel biomarker of malignant transformation in glioma". Oncology Letters 4.6 (2012): 1321-1324.
Chicago
Ma, R., Zhang, G., Wang, H., Lv, H., Fang, F., Kang, X."Downregulation of miR-544 in tissue, but not in serum, is a novel biomarker of malignant transformation in glioma". Oncology Letters 4, no. 6 (2012): 1321-1324. https://doi.org/10.3892/ol.2012.918
Copy and paste a formatted citation
x
Spandidos Publications style
Ma R, Zhang G, Wang H, Lv H, Fang F and Kang X: Downregulation of miR-544 in tissue, but not in serum, is a novel biomarker of malignant transformation in glioma. Oncol Lett 4: 1321-1324, 2012.
APA
Ma, R., Zhang, G., Wang, H., Lv, H., Fang, F., & Kang, X. (2012). Downregulation of miR-544 in tissue, but not in serum, is a novel biomarker of malignant transformation in glioma. Oncology Letters, 4, 1321-1324. https://doi.org/10.3892/ol.2012.918
MLA
Ma, R., Zhang, G., Wang, H., Lv, H., Fang, F., Kang, X."Downregulation of miR-544 in tissue, but not in serum, is a novel biomarker of malignant transformation in glioma". Oncology Letters 4.6 (2012): 1321-1324.
Chicago
Ma, R., Zhang, G., Wang, H., Lv, H., Fang, F., Kang, X."Downregulation of miR-544 in tissue, but not in serum, is a novel biomarker of malignant transformation in glioma". Oncology Letters 4, no. 6 (2012): 1321-1324. https://doi.org/10.3892/ol.2012.918
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team