Human MutY homolog induces apoptosis in etoposide‑treated HEK293 cells

  • Authors:
    • Soo‑Hyun Hahm
    • Ji Hyung Chung
    • Lia Agustina
    • Se‑Hee Han
    • In‑Soo Yoon
    • Jong‑Hwa Park
    • Lin‑Woo Kang
    • Jin Woo Park
    • Jong Joo Na
    • Ye Sun Han
  • View Affiliations

  • Published online on: September 19, 2012     https://doi.org/10.3892/ol.2012.921
  • Pages: 1203-1208
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Abstract

Etoposide (ETP) treatment of ataxia telangiectasia mutated (ATM) and Rad3‑related protein (ATR)‑, topoisomerase‑binding protein‑1 (TopBP1) and human MutY homolog (hMYH)‑depleted cells results in a significant reduction in apoptotic signaling. The association between ATR or TopBP1 and hMYH increased following ETP treatment. In hMYH knockdown cells, the interaction between ATR and TopBP1 decreased following ETP treatment. We suggest that hMYH functions as a sensor of ETP‑induced apoptosis. The results suggest that in the absence of hMYH, cells are unable to recognize the damage signal and the ATR pathway is not activated.
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December 2012
Volume 4 Issue 6

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Spandidos Publications style
Hahm SH, Chung JH, Agustina L, Han SH, Yoon IS, Park JH, Kang LW, Park JW, Na JJ, Han YS, Han YS, et al: Human MutY homolog induces apoptosis in etoposide‑treated HEK293 cells. Oncol Lett 4: 1203-1208, 2012
APA
Hahm, S., Chung, J.H., Agustina, L., Han, S., Yoon, I., Park, J. ... Han, Y.S. (2012). Human MutY homolog induces apoptosis in etoposide‑treated HEK293 cells. Oncology Letters, 4, 1203-1208. https://doi.org/10.3892/ol.2012.921
MLA
Hahm, S., Chung, J. H., Agustina, L., Han, S., Yoon, I., Park, J., Kang, L., Park, J. W., Na, J. J., Han, Y. S."Human MutY homolog induces apoptosis in etoposide‑treated HEK293 cells". Oncology Letters 4.6 (2012): 1203-1208.
Chicago
Hahm, S., Chung, J. H., Agustina, L., Han, S., Yoon, I., Park, J., Kang, L., Park, J. W., Na, J. J., Han, Y. S."Human MutY homolog induces apoptosis in etoposide‑treated HEK293 cells". Oncology Letters 4, no. 6 (2012): 1203-1208. https://doi.org/10.3892/ol.2012.921