Angiopoietin-like protein ANGPTL2 gene expression is correlated with lymph node metastasis in lung cancer

  • Authors:
    • Hidefumi Sasaki
    • Ayumi Suzuki
    • Masayuki Shitara
    • Yu Hikosaka
    • Katsuhiro  Okuda
    • Satoru Moriyama
    • Motoki Yano
    • Yoshitaka Fujii
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  • Published online on: September 20, 2012     https://doi.org/10.3892/ol.2012.924
  • Pages: 1325-1328
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Abstract

Inflammation plays key roles at various stages of tumor development, including invasion and metastasis. In mice, the angiopoietin-like protein (ANGPTL2) gene has been implicated in inflammatory carcinogenesis. ANGPTL2 mRNA expression was investigated by real-time polymerase chain reaction (RT-PCR) assay using LightCycler in surgically treated non-small cell lung cancer (NSCLC) cases. In total, 110 surgically resected NSCLC cases were used for mRNA level analyses. The ANGPTL2/β-actin mRNA levels were not significantly different between lung cancer (1598.481±6465.781) and adjacent normal lung tissues (2116.639±8337.331, P=0.5453). The tumor/normal (T/N) ratio of ANGPTL2/β-actin mRNA levels was not different between gender, age, smoking status and pathological stages. The T/N ratio of ANGPTL2/β-actin mRNA levels was significantly higher in lymph node metastasis-positive cases (2.173±3.151) compared with lymph node metastasis-negative cases (1.212±1.778, P=0.0464). However, ANGPTL2 mRNA status was not correlated with tumor invasion status. Thus, ANGPTL2 may drive metastasis and provide a candidate for blockade of its function as a strategy to antagonize the metastatic process in NSCLC.
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December 2012
Volume 4 Issue 6

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Spandidos Publications style
Sasaki H, Suzuki A, Shitara M, Hikosaka Y, Okuda K, Moriyama S, Yano M and Fujii Y: Angiopoietin-like protein ANGPTL2 gene expression is correlated with lymph node metastasis in lung cancer. Oncol Lett 4: 1325-1328, 2012
APA
Sasaki, H., Suzuki, A., Shitara, M., Hikosaka, Y., Okuda, K., Moriyama, S. ... Fujii, Y. (2012). Angiopoietin-like protein ANGPTL2 gene expression is correlated with lymph node metastasis in lung cancer. Oncology Letters, 4, 1325-1328. https://doi.org/10.3892/ol.2012.924
MLA
Sasaki, H., Suzuki, A., Shitara, M., Hikosaka, Y., Okuda, K., Moriyama, S., Yano, M., Fujii, Y."Angiopoietin-like protein ANGPTL2 gene expression is correlated with lymph node metastasis in lung cancer". Oncology Letters 4.6 (2012): 1325-1328.
Chicago
Sasaki, H., Suzuki, A., Shitara, M., Hikosaka, Y., Okuda, K., Moriyama, S., Yano, M., Fujii, Y."Angiopoietin-like protein ANGPTL2 gene expression is correlated with lymph node metastasis in lung cancer". Oncology Letters 4, no. 6 (2012): 1325-1328. https://doi.org/10.3892/ol.2012.924