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December 2012 Volume 4 Issue 6

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International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

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International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

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Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

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Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

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Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

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Article

In vitro and in vivo growth inhibition of drug-resistant ovarian carcinoma cells using a combination of cisplatin and a TRAIL-encoding retrovirus

  • Authors:
    • Fang Li
    • Yi Guo
    • Lingfei Han
    • Yankang Duan
    • Fang Fang
    • Sumei Niu
    • Qiujie Ba
    • Huaishi Zhu
    • Fanfei Kong
    • Chao Lin
    • Xuejun Wen
  • View Affiliations / Copyright

    Affiliations: Cervical Disease Centre, Shanghai First Maternity and Infant Hospital, Tongji University School of Medicine, Shanghai 200040, P.R. China, Department of Radiology, Huangpu District Central Hospital, Shanghai 200002, P.R. China, The Institute for Advanced Materials and Nano Biomedicine, Tongji University, Shanghai 200092, P.R. China
  • Pages: 1254-1258
    |
    Published online on: September 20, 2012
       https://doi.org/10.3892/ol.2012.926
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Abstract

Retroviruses encoding the TNF-related apoptosis-inducing ligand (TRAIL) gene were generated by transient transfection of the retrovirus packing cell line BOSC 23 using TRAIL-encoding plasmid. The retrovirus was able to transduce drug-resistant A2780/DDP ovarian carcinoma cells in vitro and induce TRAIL expression in the cells, as detected by western blot assay. Furthermore, the TRAIL protein led to the growth inhibition of the cells via a caspase-activated apoptotic mechanism. It was confirmed that exposure of such cells to cisplatin in combination with the TRAIL-encoding retrovirus resulted in higher anticancer activity in vitro and in the xenograft A2780/DDP tumor in a nude mouse model. This study suggests that chemotherapy in combination with TRAIL gene therapy may be an efficient approach to treat drug-resistant ovarian cancer.
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Copy and paste a formatted citation
Spandidos Publications style
Li F, Guo Y, Han L, Duan Y, Fang F, Niu S, Ba Q, Zhu H, Kong F, Lin C, Lin C, et al: In vitro and in vivo growth inhibition of drug-resistant ovarian carcinoma cells using a combination of cisplatin and a TRAIL-encoding retrovirus. Oncol Lett 4: 1254-1258, 2012.
APA
Li, F., Guo, Y., Han, L., Duan, Y., Fang, F., Niu, S. ... Wen, X. (2012). In vitro and in vivo growth inhibition of drug-resistant ovarian carcinoma cells using a combination of cisplatin and a TRAIL-encoding retrovirus. Oncology Letters, 4, 1254-1258. https://doi.org/10.3892/ol.2012.926
MLA
Li, F., Guo, Y., Han, L., Duan, Y., Fang, F., Niu, S., Ba, Q., Zhu, H., Kong, F., Lin, C., Wen, X."In vitro and in vivo growth inhibition of drug-resistant ovarian carcinoma cells using a combination of cisplatin and a TRAIL-encoding retrovirus". Oncology Letters 4.6 (2012): 1254-1258.
Chicago
Li, F., Guo, Y., Han, L., Duan, Y., Fang, F., Niu, S., Ba, Q., Zhu, H., Kong, F., Lin, C., Wen, X."In vitro and in vivo growth inhibition of drug-resistant ovarian carcinoma cells using a combination of cisplatin and a TRAIL-encoding retrovirus". Oncology Letters 4, no. 6 (2012): 1254-1258. https://doi.org/10.3892/ol.2012.926
Copy and paste a formatted citation
x
Spandidos Publications style
Li F, Guo Y, Han L, Duan Y, Fang F, Niu S, Ba Q, Zhu H, Kong F, Lin C, Lin C, et al: In vitro and in vivo growth inhibition of drug-resistant ovarian carcinoma cells using a combination of cisplatin and a TRAIL-encoding retrovirus. Oncol Lett 4: 1254-1258, 2012.
APA
Li, F., Guo, Y., Han, L., Duan, Y., Fang, F., Niu, S. ... Wen, X. (2012). In vitro and in vivo growth inhibition of drug-resistant ovarian carcinoma cells using a combination of cisplatin and a TRAIL-encoding retrovirus. Oncology Letters, 4, 1254-1258. https://doi.org/10.3892/ol.2012.926
MLA
Li, F., Guo, Y., Han, L., Duan, Y., Fang, F., Niu, S., Ba, Q., Zhu, H., Kong, F., Lin, C., Wen, X."In vitro and in vivo growth inhibition of drug-resistant ovarian carcinoma cells using a combination of cisplatin and a TRAIL-encoding retrovirus". Oncology Letters 4.6 (2012): 1254-1258.
Chicago
Li, F., Guo, Y., Han, L., Duan, Y., Fang, F., Niu, S., Ba, Q., Zhu, H., Kong, F., Lin, C., Wen, X."In vitro and in vivo growth inhibition of drug-resistant ovarian carcinoma cells using a combination of cisplatin and a TRAIL-encoding retrovirus". Oncology Letters 4, no. 6 (2012): 1254-1258. https://doi.org/10.3892/ol.2012.926
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