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December 2012 Volume 4 Issue 6

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International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

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International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

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Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

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Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

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Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

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Article

Sphere-forming tumor cells possess stem-like properties in human fibrosarcoma primary tumors and cell lines

  • Authors:
    • Wei-Dong Liu
    • Tao Zhang
    • Chun-Lei Wang
    • Hong-Mei Meng
    • Yu-Wen Song
    • Zhe Zhao
    • Zheng-Min Li
    • Jiang-Kun Liu
    • Shang-Ha Pan
    • Wen-Bo Wang

  • View Affiliations / Copyright

    Affiliations: Department of Orthopedics, The First Affiliated Hospital of Harbin Medical University, Harbin, P.R. China, Department of Orthopedics, The Affiliated Tumor Hospital of Harbin Medical University, Harbin, P.R. China, Central Laboratory, The First Affiliated Hospital of Harbin Medical University, Harbin, P.R. China
  • Pages: 1315-1320
    |
    Published online on: September 26, 2012
       https://doi.org/10.3892/ol.2012.940
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Abstract

Fibrosarcoma is a malignant soft tissue tumor of mesenchymal origin. Despite advances in medical and surgical treatment, patient survival rates have remained poor. According to the cancer stem cell hypothesis, tumors are comprised of heterogeneous cell populations that have different roles in tumor formation and growth. Cancer stem cells are a small cell subpopulation that exhibits stem‑like properties to gain aggressiveness and recurrence. These cells have been identified in a variety of cancerous tumors, but not in human fibrosarcoma. In this study, we observed that HT1080 cells and primary fibrosarcoma cells formed spheres and showed higher self-renewal capacity, invasiveness and drug resistance compared with their adherent counterparts. Moreover, we demonstrated that the cells showed higher expression of the embryonic stem cell-related genes Nanog, Oct3/4, Sox2, Sox10 and their encoding proteins, as well as greater tumorigenic capacity in nude mice. In conclusion, our data suggest the presence of a stem-like cell population in human fibrosarcoma tumors, which provides more evidence for the cancer stem cell hypothesis and assistance in designing new therapeutic strategies against human fibrosarcoma.
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Copy and paste a formatted citation
Spandidos Publications style
Liu W, Zhang T, Wang C, Meng H, Song Y, Zhao Z, Li Z, Liu J, Pan S, Wang W, Wang W, et al: Sphere-forming tumor cells possess stem-like properties in human fibrosarcoma primary tumors and cell lines. Oncol Lett 4: 1315-1320, 2012.
APA
Liu, W., Zhang, T., Wang, C., Meng, H., Song, Y., Zhao, Z. ... Wang, W. (2012). Sphere-forming tumor cells possess stem-like properties in human fibrosarcoma primary tumors and cell lines. Oncology Letters, 4, 1315-1320. https://doi.org/10.3892/ol.2012.940
MLA
Liu, W., Zhang, T., Wang, C., Meng, H., Song, Y., Zhao, Z., Li, Z., Liu, J., Pan, S., Wang, W."Sphere-forming tumor cells possess stem-like properties in human fibrosarcoma primary tumors and cell lines". Oncology Letters 4.6 (2012): 1315-1320.
Chicago
Liu, W., Zhang, T., Wang, C., Meng, H., Song, Y., Zhao, Z., Li, Z., Liu, J., Pan, S., Wang, W."Sphere-forming tumor cells possess stem-like properties in human fibrosarcoma primary tumors and cell lines". Oncology Letters 4, no. 6 (2012): 1315-1320. https://doi.org/10.3892/ol.2012.940
Copy and paste a formatted citation
x
Spandidos Publications style
Liu W, Zhang T, Wang C, Meng H, Song Y, Zhao Z, Li Z, Liu J, Pan S, Wang W, Wang W, et al: Sphere-forming tumor cells possess stem-like properties in human fibrosarcoma primary tumors and cell lines. Oncol Lett 4: 1315-1320, 2012.
APA
Liu, W., Zhang, T., Wang, C., Meng, H., Song, Y., Zhao, Z. ... Wang, W. (2012). Sphere-forming tumor cells possess stem-like properties in human fibrosarcoma primary tumors and cell lines. Oncology Letters, 4, 1315-1320. https://doi.org/10.3892/ol.2012.940
MLA
Liu, W., Zhang, T., Wang, C., Meng, H., Song, Y., Zhao, Z., Li, Z., Liu, J., Pan, S., Wang, W."Sphere-forming tumor cells possess stem-like properties in human fibrosarcoma primary tumors and cell lines". Oncology Letters 4.6 (2012): 1315-1320.
Chicago
Liu, W., Zhang, T., Wang, C., Meng, H., Song, Y., Zhao, Z., Li, Z., Liu, J., Pan, S., Wang, W."Sphere-forming tumor cells possess stem-like properties in human fibrosarcoma primary tumors and cell lines". Oncology Letters 4, no. 6 (2012): 1315-1320. https://doi.org/10.3892/ol.2012.940
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