Histological evaluation of bone biopsy results during PVP or PKP of vertebral compression fractures

  • Authors:
    • Lei Zhang
    • Jigang Li
    • Huilin Yang
    • Zongping Luo
    • Jun Zou
  • View Affiliations

  • Published online on: September 28, 2012     https://doi.org/10.3892/ol.2012.944
  • Pages: 135-138
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )


Abstract

Percutaneous vertebroplasty (PVP) or percutaneous kyphoplasty (PKP) is utilized for the treatment of vertebral compression fractures (VCFs). The present study was conducted to evaluate biopsy results obtained from VCFs during PVP or PKP. Between January 2003 and December 2011, 692 vertebral body biopsies were obtained from 546 patients (442 females and 104 males; mean age, 72.3 years), who underwent PVP or PKP for treatment of VCFs. A history of malignancy was identified in 44 patients. Histological/immunohistochemical evaluations were performed by experienced pathologists and 89.9% of biopsies obtained from 546 patients were suitable for histological/immunohistochemical evaluation. The biopsy results of 398 patients were in good agreement with the diagnosis of osteoporotic VCFs. Among the 44 patients with a history of malignancy, malignancy was identified in 25 patients, while osteoporosis was identified in 16 patients. Biopsies of the other 3 patients were not suitable for pathological examination. There were only 2 patients with previously undiagnosed malignancy. One patient was diagnosed with multiple myeloma, while another patient was diagnosed with metastatic carcinoma. In the present study, the rate of unsuspected malignancy was 0.4%. No symptomatic complications occurred as a result of biopsy. The results indicate that biopsy is safely performed during PVP or PKP and it is an efficacious procedure that verifies the pathological process and assists in identifying previously unsuspected processes responsible for VCFs. We recommend obtaining the biopsy of every collapsed vertebral body during PVP or PKP procedures.
View Figures
View References

Related Articles

Journal Cover

January 2013
Volume 5 Issue 1

Print ISSN: 1792-1074
Online ISSN:1792-1082

Sign up for eToc alerts

Recommend to Library

Copy and paste a formatted citation
x
Spandidos Publications style
Zhang L, Li J, Yang H, Luo Z and Zou J: Histological evaluation of bone biopsy results during PVP or PKP of vertebral compression fractures. Oncol Lett 5: 135-138, 2013
APA
Zhang, L., Li, J., Yang, H., Luo, Z., & Zou, J. (2013). Histological evaluation of bone biopsy results during PVP or PKP of vertebral compression fractures. Oncology Letters, 5, 135-138. https://doi.org/10.3892/ol.2012.944
MLA
Zhang, L., Li, J., Yang, H., Luo, Z., Zou, J."Histological evaluation of bone biopsy results during PVP or PKP of vertebral compression fractures". Oncology Letters 5.1 (2013): 135-138.
Chicago
Zhang, L., Li, J., Yang, H., Luo, Z., Zou, J."Histological evaluation of bone biopsy results during PVP or PKP of vertebral compression fractures". Oncology Letters 5, no. 1 (2013): 135-138. https://doi.org/10.3892/ol.2012.944