Gastrointestinal bleeding as an initial manifestation in asymptomatic multiple myeloma: A case report and review of the literature
- Authors:
- Maosong Lin
- Jiayi Zhu
- Hongzhang Shen
- Junxing Huang
View Affiliations
Affiliations: Department of Gastroenterology, Taizhou People's Hospital, Taizhou, Jiangsu 225300, P.R. China, Department of Oncology, Taizhou People's Hospital, Taizhou, Jiangsu 225300, P.R. China
- Published online on: October 1, 2012 https://doi.org/10.3892/ol.2012.945
-
Pages:
218-220
Metrics: Total
Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
This article is mentioned in:
Abstract
Multiple myeloma (MM) is an uncommon type of malignant hematological neoplasm which, besides primarily involving the bone marrow, has a potent tendency to involve other organs and to present with various clinical manifestations. Involvement of the gastrointestinal (GI) system, particularly presenting with GI hemorrhage, in the course of MM is extremely rare. In the present study, we report a case of a middle‑aged male who initially demonstrated GI bleeding and was finally diagnosed with MM. Further laboratory examinations, including analysis of globulin in the blood, bone marrow aspiration and radiogram, supported this diagnosis. This case may promote the possible involvement of plasma cell myeloma in the differential diagnosis of patients with unexplained and refractory GI bleeding. In this study we also present a thorough review of the literature with regard to the association between MM and GI hemorrhage.
View References
|
1
|
Yoshida T: Complicated gastrointestinal
bleeding of neoplastic diseases of the hematopoietic system. Nihon
Rinsho. 56:2405–2410. 1998.(In Japanese).
|
|
2
|
Kyle RA and Rajkumar SV: Multiple myeloma.
N Engl J Med. 3518:1860–1873. 2004. View Article : Google Scholar
|
|
3
|
Kapadia SB: Multiple myeloma: A
clinicopathologic study of 62 consecutively autopsied cases.
Medicine. 59:380–392. 1980. View Article : Google Scholar : PubMed/NCBI
|
|
4
|
Cherpanath TGV, Nieuwdorp M, Hazenberg MD,
et al: Large nocturnal eyes causing gastrointestinal bleeding in
asymptomatic multiple myeloma. Neth J Med. 68:324–327.
2010.PubMed/NCBI
|
|
5
|
Dolin S and Dewer JP: Extramedullary
plasmacytoma. Am J Pathol. 32:83–103. 1956.
|
|
6
|
Talamo G, Cavallo F, Zangari M, et al:
Clinical and biological features of multiple myeloma involving the
gastrointestinal system. Haematologica. 91:964–967. 2006.PubMed/NCBI
|
|
7
|
Daram SR, Paine ER and Swingley AF: Upper
gastrointestinal bleeding in a patient with multiple myeloma.
Gastroenterology. 142:e8–e9. 2012. View Article : Google Scholar : PubMed/NCBI
|
|
8
|
Vicuña Arregui M, Borobio Aguilar E, Vila
Costas JJ, et al: Gastric plasmacytoma as an uncommon cause of
upper gastrointestinal bleeding. Gastroenterol Hepatol. 31:217–220.
2008.(In Spanish).
|
|
9
|
Suvannasankha A, Abonour R, Cummings OW
and Liangpunsakul S: Gastrointestinal plasmacytoma presenting as
gastrointestinal bleeding. Clin Lymphoma Myeloma. 8:309–311. 2008.
View Article : Google Scholar : PubMed/NCBI
|
|
10
|
Chang SS, Lu CL, Tsay SH, et al:
Amyloidosis-induced gastrointestinal bleeding in a patient with
multiple myeloma. J Clin Gastroenterol. 32:161–163. 2001.
View Article : Google Scholar : PubMed/NCBI
|
|
11
|
Alvares JF, Thomas J, Ramakrishna K, et
al: Multiple myeloma with amyloidosis presenting with recurrent
gastrointestinal bleeding. Indian J Gastroenterol.
22:1962003.PubMed/NCBI
|
|
12
|
Maza I, Vlodavsky E and Eliakim RA: Rectal
bleeding as a presenting symptom of AL amyloidosis and multiple
myeloma. World J Gastrointest Endosc. 2:44–46. 2010. View Article : Google Scholar : PubMed/NCBI
|
|
13
|
DiMinno G, Coraggio F, Cerbone AM, et al:
Myeloma paraprotein with specificity for platelet glycoprotein ilia
in a patient with a fatal bleeding disorder. J Clin Invest.
77:157–164. 1986. View Article : Google Scholar : PubMed/NCBI
|
|
14
|
Saif MW, Allegra CJ and Greenberg B:
Bleeding diathesis in multiple myeloma. J Hematother Stem Cell Res.
10:657–660. 2001. View Article : Google Scholar : PubMed/NCBI
|
|
15
|
Dawson MA, Polizzotto MN, Gordon A, et al:
Extramedullary relapse of multiple myeloma presenting as
hematemesis and melena. Nat Clin Pract Oncol. 3:223–226. 2006.
View Article : Google Scholar : PubMed/NCBI
|
|
16
|
Kyle RA and Rajkumar SV: Criteria for
diagnosis, staging, risk stratification and response assessment of
multiple myeloma. Leukemia. 23:3–9. 2009. View Article : Google Scholar : PubMed/NCBI
|
