Gastrointestinal bleeding as an initial manifestation in asymptomatic multiple myeloma: A case report and review of the literature

Lin,Maosong; Zhu,Jiayi; Shen,Hongzhang; Huang,Junxing

doi:10.3892/ol.2012.945

January 2013 Volume 5 Issue 1

Full Size Image

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

An International Open Access Journal Devoted to General Medicine.

January 2013 Volume 5 Issue 1

Full Size Image

Case Report

Gastrointestinal bleeding as an initial manifestation in asymptomatic multiple myeloma: A case report and review of the literature

Authors:
- Maosong Lin
- Jiayi Zhu
- Hongzhang Shen
- Junxing Huang
View Affiliations / Copyright

Affiliations: Department of Gastroenterology, Taizhou People's Hospital, Taizhou, Jiangsu 225300, P.R. China, Department of Oncology, Taizhou People's Hospital, Taizhou, Jiangsu 225300, P.R. China
Pages: 218-220
|
Published online on: October 1, 2012

https://doi.org/10.3892/ol.2012.945
Expand metrics +

Abstract

Multiple myeloma (MM) is an uncommon type of malignant hematological neoplasm which, besides primarily involving the bone marrow, has a potent tendency to involve other organs and to present with various clinical manifestations. Involvement of the gastrointestinal (GI) system, particularly presenting with GI hemorrhage, in the course of MM is extremely rare. In the present study, we report a case of a middle‑aged male who initially demonstrated GI bleeding and was finally diagnosed with MM. Further laboratory examinations, including analysis of globulin in the blood, bone marrow aspiration and radiogram, supported this diagnosis. This case may promote the possible involvement of plasma cell myeloma in the differential diagnosis of patients with unexplained and refractory GI bleeding. In this study we also present a thorough review of the literature with regard to the association between MM and GI hemorrhage.

View Figures

View References

1	Yoshida T: Complicated gastrointestinal bleeding of neoplastic diseases of the hematopoietic system. Nihon Rinsho. 56:2405–2410. 1998.(In Japanese).
2	Kyle RA and Rajkumar SV: Multiple myeloma. N Engl J Med. 3518:1860–1873. 2004. View Article : Google Scholar
3	Kapadia SB: Multiple myeloma: A clinicopathologic study of 62 consecutively autopsied cases. Medicine. 59:380–392. 1980. View Article : Google Scholar : PubMed/NCBI
4	Cherpanath TGV, Nieuwdorp M, Hazenberg MD, et al: Large nocturnal eyes causing gastrointestinal bleeding in asymptomatic multiple myeloma. Neth J Med. 68:324–327. 2010.PubMed/NCBI
5	Dolin S and Dewer JP: Extramedullary plasmacytoma. Am J Pathol. 32:83–103. 1956.
6	Talamo G, Cavallo F, Zangari M, et al: Clinical and biological features of multiple myeloma involving the gastrointestinal system. Haematologica. 91:964–967. 2006.PubMed/NCBI
7	Daram SR, Paine ER and Swingley AF: Upper gastrointestinal bleeding in a patient with multiple myeloma. Gastroenterology. 142:e8–e9. 2012. View Article : Google Scholar : PubMed/NCBI
8	Vicuña Arregui M, Borobio Aguilar E, Vila Costas JJ, et al: Gastric plasmacytoma as an uncommon cause of upper gastrointestinal bleeding. Gastroenterol Hepatol. 31:217–220. 2008.(In Spanish).
9	Suvannasankha A, Abonour R, Cummings OW and Liangpunsakul S: Gastrointestinal plasmacytoma presenting as gastrointestinal bleeding. Clin Lymphoma Myeloma. 8:309–311. 2008. View Article : Google Scholar : PubMed/NCBI
10	Chang SS, Lu CL, Tsay SH, et al: Amyloidosis-induced gastrointestinal bleeding in a patient with multiple myeloma. J Clin Gastroenterol. 32:161–163. 2001. View Article : Google Scholar : PubMed/NCBI
11	Alvares JF, Thomas J, Ramakrishna K, et al: Multiple myeloma with amyloidosis presenting with recurrent gastrointestinal bleeding. Indian J Gastroenterol. 22:1962003.PubMed/NCBI
12	Maza I, Vlodavsky E and Eliakim RA: Rectal bleeding as a presenting symptom of AL amyloidosis and multiple myeloma. World J Gastrointest Endosc. 2:44–46. 2010. View Article : Google Scholar : PubMed/NCBI
13	DiMinno G, Coraggio F, Cerbone AM, et al: Myeloma paraprotein with specificity for platelet glycoprotein ilia in a patient with a fatal bleeding disorder. J Clin Invest. 77:157–164. 1986. View Article : Google Scholar : PubMed/NCBI
14	Saif MW, Allegra CJ and Greenberg B: Bleeding diathesis in multiple myeloma. J Hematother Stem Cell Res. 10:657–660. 2001. View Article : Google Scholar : PubMed/NCBI
15	Dawson MA, Polizzotto MN, Gordon A, et al: Extramedullary relapse of multiple myeloma presenting as hematemesis and melena. Nat Clin Pract Oncol. 3:223–226. 2006. View Article : Google Scholar : PubMed/NCBI
16	Kyle RA and Rajkumar SV: Criteria for diagnosis, staging, risk stratification and response assessment of multiple myeloma. Leukemia. 23:3–9. 2009. View Article : Google Scholar : PubMed/NCBI

Journals

International Journal of Molecular Medicine

International Journal of Oncology

Molecular Medicine Reports

Oncology Reports

Experimental and Therapeutic Medicine

Oncology Letters

Biomedical Reports

Molecular and Clinical Oncology

World Academy of Sciences Journal

International Journal of Functional Nutrition

International Journal of Epigenetics

Medicine International

Gastrointestinal bleeding as an initial manifestation in asymptomatic multiple myeloma: A case report and review of the literature

This article is mentioned in:

Abstract

Figure 1

Figure 2

Related Articles