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Article

The CXCL12/CXCR4 autocrine loop increases the metastatic potential of non-small cell lung cancer in vitro

  • Authors:
    • Xiaofeng Dai
    • Zhifu Mao
    • Songping Xie
    • Hao Zhang
    • Jie Huang
  • View Affiliations / Copyright

    Affiliations: Department of Cardiothoracic Surgery, Renmin Hospital of Wuhan University, Wuhan, Hubei 430060, P.R. China
  • Pages: 277-282
    |
    Published online on: October 10, 2012
       https://doi.org/10.3892/ol.2012.960
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Abstract

The CXCL12/CXCR4 endocrine axis has been demonstrated to play a pivotal role in organ-specific metastasis of many different types of tumors, but the precise role of the CXCL12/CXCR4 autocrine loop remains poorly understood. In this study, we constructed a functional CXCL12/CXCR4 autocrine loop in A549 cells using a gene transfection technique to evaluate its effect on the metastasis of non-small cell lung cancer (NSCLC). Our results demonstrated that the CXCL12/CXCR4 autocrine loop significantly promoted the motility, proliferation and invasiveness of the A549 cells, suggesting a key role of the CXCL12/CXCR4 autocrine loop in NSCLC metastasis. In addition, these findings suggest that targeted therapies directed against CXCR4 should consider the CXCL12 expression status of the NSCLC to be treated, since tumors with autocrine overexpression of CXCL12 may be more suitable for the application of chemokine-based anti-cancer therapies.
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Copy and paste a formatted citation
Spandidos Publications style
Dai X, Mao Z, Xie S, Zhang H and Huang J: The CXCL12/CXCR4 autocrine loop increases the metastatic potential of non-small cell lung cancer in vitro. Oncol Lett 5: 277-282, 2013.
APA
Dai, X., Mao, Z., Xie, S., Zhang, H., & Huang, J. (2013). The CXCL12/CXCR4 autocrine loop increases the metastatic potential of non-small cell lung cancer in vitro. Oncology Letters, 5, 277-282. https://doi.org/10.3892/ol.2012.960
MLA
Dai, X., Mao, Z., Xie, S., Zhang, H., Huang, J."The CXCL12/CXCR4 autocrine loop increases the metastatic potential of non-small cell lung cancer in vitro". Oncology Letters 5.1 (2013): 277-282.
Chicago
Dai, X., Mao, Z., Xie, S., Zhang, H., Huang, J."The CXCL12/CXCR4 autocrine loop increases the metastatic potential of non-small cell lung cancer in vitro". Oncology Letters 5, no. 1 (2013): 277-282. https://doi.org/10.3892/ol.2012.960
Copy and paste a formatted citation
x
Spandidos Publications style
Dai X, Mao Z, Xie S, Zhang H and Huang J: The CXCL12/CXCR4 autocrine loop increases the metastatic potential of non-small cell lung cancer in vitro. Oncol Lett 5: 277-282, 2013.
APA
Dai, X., Mao, Z., Xie, S., Zhang, H., & Huang, J. (2013). The CXCL12/CXCR4 autocrine loop increases the metastatic potential of non-small cell lung cancer in vitro. Oncology Letters, 5, 277-282. https://doi.org/10.3892/ol.2012.960
MLA
Dai, X., Mao, Z., Xie, S., Zhang, H., Huang, J."The CXCL12/CXCR4 autocrine loop increases the metastatic potential of non-small cell lung cancer in vitro". Oncology Letters 5.1 (2013): 277-282.
Chicago
Dai, X., Mao, Z., Xie, S., Zhang, H., Huang, J."The CXCL12/CXCR4 autocrine loop increases the metastatic potential of non-small cell lung cancer in vitro". Oncology Letters 5, no. 1 (2013): 277-282. https://doi.org/10.3892/ol.2012.960
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