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Article

Polymorphisms in bone morphogenetic protein 3 and the risk of papillary thyroid cancer

  • Authors:
    • Young Ock Kim
    • Il Ki Hong
    • Young Gyu Eun
    • Seong‑Su Nah
    • Soojeong Lee
    • Su‑Hak Heo
    • Hyung-Kee Kim
    • Ho‑Yeon Song
    • Hak‑Jae Kim
  • View Affiliations / Copyright

    Affiliations: Development of Ginseng and Medical Plants Research Institute, Rural Administration, Eumseong, Republic of Korea, Department of Otolaryngology‑Head and Neck Surgery, School of Medicine, Kyung Hee University, Seoul, Republic of Korea, Division of Rheumatology, Department of Internal Medicine, College of Medicine, Soonchunhyang University, Cheonan, Republic of Korea, Department of Microbiology, College of Medicine, Soonchunhyang University, Cheonan, Republic of Korea , Soonchunhyang Medical Research Institute, College of Medicine, Soonchunhyang University, Cheonan, Republic of Korea , Clinical Pharmacology, College of Medicine, Soonchunhyang University, Cheonan, Republic of Korea
  • Pages: 336-340
    |
    Published online on: October 10, 2012
       https://doi.org/10.3892/ol.2012.962
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Abstract

Bone morphogenetic proteins (BMPs) are members of the transforming growth factor beta (TGFβ) superfamily with well‑described functions in bone formation. Although disrupted BMP signaling in tumor development has been investigated, a genetic association for BMP3 in papillary thyroid cancer (PTC) has remained largely unexplored. In this study, we investigated whether BMP3 single nucleotide polymorphisms (SNPs) are associated with the development of PTC and its clinicopathological features. A total of 103 PTC patients and 324 control subjects were enrolled. One promoter SNP (rs13138132; ‑1919C/A) and one missense mutation (rs3733549; Arg192Gln) in BMP3 were genotyped by direct sequencing. SNPStats, SNPAnalyzer, Helixtree and Haploview version 4.2 were used to evaluate the genetic data. Multiple logistic regression models were used to calculate odds ratios (ORs), 95% confidence intervals (CIs) and P‑values. The missense SNP (rs3733549) was weakly associated with the development of PTC in a codominant model (AA vs. GG; P=0.017) and a recessive model (AA vs. GG/GA; P=0.023). Additionally, in an analysis according to clinicopathological features, rs13138132 was significantly associated with extrathyroidal invasion in a codominant model (CA vs. CC; P=0.006) and a dominant model (CA/AA vs. CC; P=0.0023). We also identified that the frequency of the A allele in the promoter SNP (rs13138132) was increased in PTC patients with extrathyroidal invasion (P=0.004). Our data suggest that rs3733549 in BMP3 is associated with the development of PTC and that the A allele of rs13138932 in BMP3 is a risk factor for extrathyroidal invasion.
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Copy and paste a formatted citation
Spandidos Publications style
Kim YO, Hong IK, Eun YG, Nah SS, Lee S, Heo SH, Kim H, Song HY and Kim HJ: Polymorphisms in bone morphogenetic protein 3 and the risk of papillary thyroid cancer. Oncol Lett 5: 336-340, 2013.
APA
Kim, Y.O., Hong, I.K., Eun, Y.G., Nah, S., Lee, S., Heo, S. ... Kim, H. (2013). Polymorphisms in bone morphogenetic protein 3 and the risk of papillary thyroid cancer. Oncology Letters, 5, 336-340. https://doi.org/10.3892/ol.2012.962
MLA
Kim, Y. O., Hong, I. K., Eun, Y. G., Nah, S., Lee, S., Heo, S., Kim, H., Song, H., Kim, H."Polymorphisms in bone morphogenetic protein 3 and the risk of papillary thyroid cancer". Oncology Letters 5.1 (2013): 336-340.
Chicago
Kim, Y. O., Hong, I. K., Eun, Y. G., Nah, S., Lee, S., Heo, S., Kim, H., Song, H., Kim, H."Polymorphisms in bone morphogenetic protein 3 and the risk of papillary thyroid cancer". Oncology Letters 5, no. 1 (2013): 336-340. https://doi.org/10.3892/ol.2012.962
Copy and paste a formatted citation
x
Spandidos Publications style
Kim YO, Hong IK, Eun YG, Nah SS, Lee S, Heo SH, Kim H, Song HY and Kim HJ: Polymorphisms in bone morphogenetic protein 3 and the risk of papillary thyroid cancer. Oncol Lett 5: 336-340, 2013.
APA
Kim, Y.O., Hong, I.K., Eun, Y.G., Nah, S., Lee, S., Heo, S. ... Kim, H. (2013). Polymorphisms in bone morphogenetic protein 3 and the risk of papillary thyroid cancer. Oncology Letters, 5, 336-340. https://doi.org/10.3892/ol.2012.962
MLA
Kim, Y. O., Hong, I. K., Eun, Y. G., Nah, S., Lee, S., Heo, S., Kim, H., Song, H., Kim, H."Polymorphisms in bone morphogenetic protein 3 and the risk of papillary thyroid cancer". Oncology Letters 5.1 (2013): 336-340.
Chicago
Kim, Y. O., Hong, I. K., Eun, Y. G., Nah, S., Lee, S., Heo, S., Kim, H., Song, H., Kim, H."Polymorphisms in bone morphogenetic protein 3 and the risk of papillary thyroid cancer". Oncology Letters 5, no. 1 (2013): 336-340. https://doi.org/10.3892/ol.2012.962
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