Elevated preoperative plasma D‑dimer levels and the incidence of venous thromboembolism in Japanese females with gynecological cancer

Kodama,Junichi; Seki,Noriko; Fukushima,Chikako; Kusumoto,Tomoyuki; Nakamura,Keiichiro; Hongo,Atsushi; Hiramatsu,Yuji

doi:10.3892/ol.2012.970

January 2013 Volume 5 Issue 1

Full Size Image

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

An International Open Access Journal Devoted to General Medicine.

January 2013 Volume 5 Issue 1

Full Size Image

Article

Elevated preoperative plasma D‑dimer levels and the incidence of venous thromboembolism in Japanese females with gynecological cancer

Authors:
- Junichi Kodama
- Noriko Seki
- Chikako Fukushima
- Tomoyuki Kusumoto
- Keiichiro Nakamura
- Atsushi Hongo
- Yuji Hiramatsu
View Affiliations / Copyright

Affiliations: Department of Obstetrics and Gynecology, Hiroshima City Hospital, Hiroshima 730‑8518, Japan, Department of Obstetrics and Gynecology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama 700‑8558, Japan
Pages: 299-304
|
Published online on: October 15, 2012

https://doi.org/10.3892/ol.2012.970
Expand metrics +

Abstract

The purpose of the present study was to determine the incidence of increased levels of D‑dimer and associated factors in preoperative patients with gynecological cancer. Furthermore, we determined the incidence and risk factors associated with preoperative venous thromboembolism (VTE). Overall, 456 patients with invasive gynecological cancer scheduled to undergo surgery were recruited. Preoperative plasma D‑dimer levels were measured and patients whose plasma D‑dimer concentration exceeded the pre‑set cut‑off value underwent computed tomography scanning. The incidence of elevated D‑dimer and VTE was identified as significantly higher in patients with ovarian cancer. Multivariate analysis revealed that advanced age, low hemoglobin levels and elevated C‑reactive protein (CRP) levels were independent factors for preoperative elevations in plasma D‑dimer levels. Advanced age was an independent risk factor for preoperative VTE. Massive ascites and the presence of co‑morbidities were independent risk factors for preoperative VTE in ovarian cancer. Advanced age and stage were independent risk factors for preoperative VTE in endometrial cancer. Advanced age was an independent risk factor for preoperative VTE in cervical cancer. Plasma D‑dimer levels and the incidence of preoperative VTE were higher in patients with ovarian cancer compared with those with other gynecological cancers. Advanced age, low hemoglobin levels and elevated CRP levels were significant factors associated with elevated plasma D‑dimer levels and age was an independent risk factor for preoperative VTE in gynecological cancer.

View Figures

View References

1	Lin A, Ryu J, Harvey D, et al: Low-dose warfarin does not decrease the rate of thrombosis in patients with cervix and vulvo-vaginal cancer treated with chemotherapy, radiation and erythropoietin. Gynecol Oncol. 102:98–102. 2006. View Article : Google Scholar : PubMed/NCBI
2	Einstein MH, Pritts EA and Hartenbach EM: Venous thromboembolism prevention in gynecologic cancer surgery: a sysytematic review. Gynecol Oncol. 105:813–819. 2007. View Article : Google Scholar : PubMed/NCBI
3	NCCN Clinical Practice Guidelines in Oncology: Venous thromboembolic disease, Version 2. National Comprehensive Cancer Network; Fort Washington, PA: 2011
4	Hunt BJ: Plasma D-dimer assays in the diagnosis of venous thromboembolism in cancer patients. J Thromb Haemost. 4:50–51. 2006. View Article : Google Scholar : PubMed/NCBI
5	Nomura H, Wada H, Mizuno T, et al: Negative predictive value of D-dimer for diagnosis of venous thromboembolism. Int J Hematol. 87:250–255. 2008. View Article : Google Scholar : PubMed/NCBI
6	Wada H, Kobayashi T, Abe Y, et al: Elevated levels of soluble fibrin or D-dimer indicate high risk of thrombosis. J Thromb Haemost. 4:1253–1258. 2006. View Article : Google Scholar : PubMed/NCBI
7	Cushman M, Folsom AR, Wang L, et al: Fibrin fragment D-dimer and the risk of future venous thrombosis. Blood. 101:1243–1248. 2003. View Article : Google Scholar : PubMed/NCBI
8	Bertina RM: Elevated clotting factor levels and venous thrombosis. Pathophysiol Haemost Thromb. 33:395–400. 2003/2004. View Article : Google Scholar : PubMed/NCBI
9	Sweenery JD and Hoerning LA: Age-dependent effect on the level of factor IX. Am J Clin Pathol. 99:687–688. 1993.PubMed/NCBI
10	O’Donnell J and Laffan MA: The relationship between ABO hist-blood group, factor VIII and von Willebrand factor. Transfus Med. 11:343–351. 2001.
11	Koster T, Blann AD, Brief E, et al: Role of clotting factor VIII in effect of von Willebrand factor on occurrence of deep-vein thrombosis. Lancet. 345:152–155. 1995. View Article : Google Scholar : PubMed/NCBI
12	Jenkins PV and O’Donnell JS: ABO blood group determines plasma von Willebrand factor levels: a biologic function after all? Transfusion. 46:1836–1844. 2006. View Article : Google Scholar : PubMed/NCBI
13	Kodama J, Seki N, Masahiro S, et al: D-dimer level as a risk factor for postoperative venous thromboembolism in Japanese women with gynecologic cancer. Ann Oncol. 21:1651–1656. 2010. View Article : Google Scholar : PubMed/NCBI
14	Khorana AA and Connolly GC: Assessing risk of venous thromboembolism in the cancer patients. J Clin Oncol. 27:4839–4847. 2009. View Article : Google Scholar : PubMed/NCBI
15	Kröger K, Weiland D, Ose C, et al: Risk factors for venous thromboembolic events in cancer patients. Ann Oncol. 17:297–303. 2006.PubMed/NCBI
16	Satoh T, Oki A, Uno K, et al: High incidence of silent venous thromboembolism before treatment in ovarian cancer. Brit J Cancer. 97:1053–1057. 2007. View Article : Google Scholar : PubMed/NCBI
17	Rodriguez AO, Wun T, Chew H, et al: Venous thromboembolism in ovarian cancer. Gynecol Oncol. 105:784–790. 2007. View Article : Google Scholar : PubMed/NCBI
18	Satoh T, Mastumoto K, Uno K, et al: Silent venous thromboembolism before treatment in endometrial cancer and the risk factors. Brit J Cancer. 99:1034–1039. 2008. View Article : Google Scholar : PubMed/NCBI
19	Barbera L and Thomas G: Venous thromboembolism in cervical cancer. Lancer Oncol. 9:54–60. 2008. View Article : Google Scholar : PubMed/NCBI

Journals

International Journal of Molecular Medicine

International Journal of Oncology

Molecular Medicine Reports

Oncology Reports

Experimental and Therapeutic Medicine

Oncology Letters

Biomedical Reports

Molecular and Clinical Oncology

World Academy of Sciences Journal

International Journal of Functional Nutrition

International Journal of Epigenetics

Medicine International

Elevated preoperative plasma D‑dimer levels and the incidence of venous thromboembolism in Japanese females with gynecological cancer

This article is mentioned in:

Abstract

Related Articles