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Article

Plasma levels of matrix metalloproteinases 2 and 9 correlate with histological grade in breast cancer patients

  • Authors:
    • Fortunata Vasaturo
    • Fabiana Solai
    • Carolina Malacrino
    • Tiziana Nardo
    • Bruno Vincenzi
    • Mauro Modesti
    • Susanna Scarpa
  • View Affiliations / Copyright

    Affiliations: Department of Emergency, University Sapienza, Rome I-00161, Italy, Department of Surgical Sciences, University Sapienza, Rome I-00161, Italy, Department of Experimental Medicine, University Sapienza, Rome I-00161, Italy, Department of Medical Oncology, University Campus Bio-Medico, Rome I-00161, Italy
  • Pages: 316-320
    |
    Published online on: October 17, 2012
       https://doi.org/10.3892/ol.2012.977
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Abstract

Matrix metalloproteinases (MMPs) are proteolytic enzymes involved in the process of tumor invasion and metastasis that are found throughout tissues and also in the plasma. The aim of this study was to investigate whether the evaluation of plasma concentrations of MMPs 2, 3 and 9 may have clinical significance in breast cancer. Therefore, sera obtained from 80 patients with breast neoplasia (50 carcinomas and 30 fibroadenomas) were collected before and 96 h after surgery and the concentrations of MMPs 2, 3 and 9 were quantified using an enzyme-linked immunosorbent assay (ELISA). The mean expression level of MMP 2 was significantly higher in carcinoma compared with that in fibroadenoma patients, while there was no significant difference for MMPs 3 and 9. In addition, the group of carcinoma patients was analyzed in order to compare the mean values for each MMP obtained before and after surgery. However, the differences between pre- and post-surgery values for all three MMPs were not statistically significant. Furthermore, the plasma levels of each MMP were correlated with certain clinicopathological parameters of the tumors and we observed a significant and direct correlation between the concentrations of MMPs 2 and 9 and tumor histological grade. These data suggest that the quantification of plasma MMP 2 and MMP 9 levels may provide additional clinical information of the tumor and it is, therefore, a possible prognostic index for breast cancer.
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1 

Egeblad M and Werb Z: New functions for the matrix metalloproteinases in cancer progression. Nat Rev Cancer. 2:161–174. 2002. View Article : Google Scholar : PubMed/NCBI

2 

Hanemaaijer R, Verheijen JH, Maguire TM, Visser H, Toet K, McDermott E, et al: Increased gelatinase-A and gelatinase-B activities in malignant vs. benign breast tumors. Int J Cancer. 2:204–207. 2000. View Article : Google Scholar : PubMed/NCBI

3 

Liotta LA: Tumor invasion and metastases - role of the extracellular matrix: Rhoads Memorial Award lecture. Cancer Res. 46:1–7. 1986.PubMed/NCBI

4 

Lynch CC and Matrisan LM: Matrix metalloproteinases in tumor-host cell communication. Differentiation. 70:561–573. 2002. View Article : Google Scholar : PubMed/NCBI

5 

Somiari SB, Shriver CD, Heckman C, Olsen C, Hu H, Jordan R, Arciero C, Russell S, Garguilo G, Hooke J and Somiari RI: Plasma concentration and activity of matrix metalloproteinase 2 and 9 in patients with breast disease, breast cancer and at risk of developing breast cancer. Cancer Lett. 233:98–107. 2006. View Article : Google Scholar : PubMed/NCBI

6 

Leppä S, Saarto T, Vehmanen L, Blomqvist C and Elomaa I: A high serum matrix metalloproteinase-2 level is associated with an adverse prognosis in node-positive breast carcinoma. Clin Cancer Res. 10:1057–1063. 2004.PubMed/NCBI

7 

Mendes O, Kim HT and Stoica G: Expression of MMP2, MMP9 and MMP3 in breast cancer brain metastasis in a rat model. Clin Exp Metastasis. 22:237–246. 2005. View Article : Google Scholar : PubMed/NCBI

8 

Baker EA, Stephenson TJ, Reed MW and Brown NJ: Expression of proteinases and inhibitors in human breast cancer progression and survival. Mol Pathol. 55:300–304. 2002. View Article : Google Scholar : PubMed/NCBI

9 

Bodey B, Bodey B Jr, Siegel SE and Kaiser HE: Matrix metalloproteinases in neoplasm-induced extracellular matrix remodelling in breast carcinoma. Anticancer Res. 21:2021–2028. 2001.PubMed/NCBI

10 

González LO, Pidal I, Junquera S, Corte MD, Vásquez J, Rodríguez JC, Lamelas ML, Merino AM, García-Muñíz JL and Vizoso FJ: Overexpression of matrix metalloproteinases and their inhibitors in mononuclear inflammatory cells in breast cancer correlates with metastasis-relapse. Br J Cancer. 97:957–963. 2007.PubMed/NCBI

11 

Talvensaari-Mattila A, Pääkkö P, Höyhtyä M, Blanco-Sequeiros G and Turpeenniemi-Hujanen T: Matrix metalloproteinase-2 immunoreactive protein: a marker of aggressiveness in breast carcinoma. Cancer. 83:1153–1162. 1998. View Article : Google Scholar : PubMed/NCBI

12 

Jezierska A and Motyl T: Matrix metalloproteinase-2 involvement in breast cancer progression: a mini-review. Med Sci Monit. 15:RA32–RA40. 2009.PubMed/NCBI

13 

Di Carlo A, Terracciano D, Mariano A and Macchia V: Matrix metalloproteinase-2 and matrix metalloproteinase-9 type IV collagenases in serum of patients with pleural effusions. Int J Oncol. 26:1363–1368. 2005.PubMed/NCBI

14 

Staack A, Badendieck S, Schnorr D, Loening SA and Jung K: Combined determination of plasma MMP2, MMP9, and TIMP1 improves the non-invasive detection of transitional cell carcinoma of the bladder. BMC Urol. 6:192006. View Article : Google Scholar : PubMed/NCBI

15 

Incorvaia L, Badalamenti G, Rini G, Arcara C, Fricano S, Sferrazza C, Di Trapani D, Gebbia N and Leto G: MMP-2, MMP-9 and activin A blood levels in patients with breast cancer or prostate cancer metastasis to the bone. Anticancer Res. 27:1519–1525. 2007.PubMed/NCBI

16 

Jinga DC, Blidaru A, Condrea I, Ardeleanu C, Dragomir C, Szegli G, Stefanescu M and Matache C: MMP-9 and MMP-2 gelatinases and TIMP-1 and TIMP-2 inhibitors in breast cancer: correlations with prognostic factors. J Cell Mol Med. 10:499–510. 2006. View Article : Google Scholar : PubMed/NCBI

17 

Stankovic C, Konjevic G, Gopcevic K, Jovic V, Inic M and Jurisic V: Activity of MMP-2 and MMP-9 in sera of breast cancer patients. Pathol Res Pract. 206:241–247. 2010. View Article : Google Scholar : PubMed/NCBI

18 

Quaranta M, Daniele A, Coviello M, Venneri MT, Abbate I, Caringella ME, Di Tardo S, Divella R, Trerotoli P, Di Gennaro M, Schittulli F, Fransvea E and Giannelli G: MMP-2, MMP-9, VEGF and CA 15.3 in breast cancer. Anticancer Res. 27:3593–3600. 2007.

19 

Ranuncolo SM, Armanasco E, Cresta C, Bal De Kier Joffe E and Puricelli L: Plasma MMP-9 (92 kDa-MMP) activity is useful in the follow-up and in the assessement of prognosis in breast cancer patients. Int J Cancer. 106:745–751. 2003. View Article : Google Scholar : PubMed/NCBI

20 

Köhrmann A, Kammerer U, Kapp M, Dietl J and Anacker J: Expression of matrix metalloproteinases (MMPs) in primary human breast cancer and breast cancer cell lines: New findings and review of the literature. BMC Cancer. 9:1882009.PubMed/NCBI

21 

Li HC, Cao DC, Liu Y, Hou YF, Wu J, Lu JS, Di GH, Liu G, Li FM, Ou ZL, Jie C, Shen ZZ and Shao ZM: Prognostic value of matrix metalloproteinases (MMP-2 and MMP-9) in patients with lymph node-negative breast carcinoma. Breast Cancer Res Treat. 88:75–85. 2004. View Article : Google Scholar : PubMed/NCBI

22 

Talvensaari-Mattila A, Pääkkö P and Turpeenniemi-Hujanen T: MMP-2 positivity and age less than 40 years increases the risk for recurrence in premenopausal patients with node-positive breast carcinoma. Breast Cancer Res Treat. 58:287–293. 1999.PubMed/NCBI

23 

Talvensaari-Mattila A, Pääkko P, Blanco-Sequeiros G and Turpeenniemi-Hujanen T: Matrix metalloproteinase-2 (MMP-2) is associated with the risk for a relapse in postmenopausal patients with node-positive breast carcinoma treated with antiestrogen adjuvant therapy. Breast Cancer Res Treat. 65:55–61. 2001. View Article : Google Scholar

24 

Atik E, Akansu B, Bakaris S and Aban N: Expression of cyclooxygenase-2 and its relation to histological grade, inducible nitric oxide synthase, matrix metalloproteinase-2, CD-34, Caspase-3, and CD8 in invasive ductal carcinoma of the breast. Saudi Med J. 31:130–134. 2010.

25 

Nassar A, Radhakrishnan A, Cabrero IA, Cotsonis G and Cohen C: COX-2 expression in invasive breast cancer: correlation with prognostic parameters and outcome. Appl Immunohistochem Mol Morphol. 15:255–259. 2007. View Article : Google Scholar : PubMed/NCBI

26 

Sivula A, Talvensaari-Mattila A, Lundin J, Joensuu H, Haglund C, Ristimaki A and Turpeenniemi-Hujanen T: Association of cyclooxygenase-2 and matrix metalloproteinase-2 expression in human breast cancer. Breast Cancer Res Treat. 89:215–220. 2005. View Article : Google Scholar : PubMed/NCBI

27 

de la Torre J, Sabadell MD, Rojo F, Lirola JL, Salaricru S, Reventos J, Ramón y Cajal S and Xercavins J: Cyclo-oxygenase type 2 is dysregulated in breast ductal carcinoma in situ and correlates with poor outcome. Eur J Obstet Gynecol Reprod Biol. 151:72–76. 2010.PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Vasaturo F, Solai F, Malacrino C, Nardo T, Vincenzi B, Modesti M and Scarpa S: Plasma levels of matrix metalloproteinases 2 and 9 correlate with histological grade in breast cancer patients. Oncol Lett 5: 316-320, 2013.
APA
Vasaturo, F., Solai, F., Malacrino, C., Nardo, T., Vincenzi, B., Modesti, M., & Scarpa, S. (2013). Plasma levels of matrix metalloproteinases 2 and 9 correlate with histological grade in breast cancer patients. Oncology Letters, 5, 316-320. https://doi.org/10.3892/ol.2012.977
MLA
Vasaturo, F., Solai, F., Malacrino, C., Nardo, T., Vincenzi, B., Modesti, M., Scarpa, S."Plasma levels of matrix metalloproteinases 2 and 9 correlate with histological grade in breast cancer patients". Oncology Letters 5.1 (2013): 316-320.
Chicago
Vasaturo, F., Solai, F., Malacrino, C., Nardo, T., Vincenzi, B., Modesti, M., Scarpa, S."Plasma levels of matrix metalloproteinases 2 and 9 correlate with histological grade in breast cancer patients". Oncology Letters 5, no. 1 (2013): 316-320. https://doi.org/10.3892/ol.2012.977
Copy and paste a formatted citation
x
Spandidos Publications style
Vasaturo F, Solai F, Malacrino C, Nardo T, Vincenzi B, Modesti M and Scarpa S: Plasma levels of matrix metalloproteinases 2 and 9 correlate with histological grade in breast cancer patients. Oncol Lett 5: 316-320, 2013.
APA
Vasaturo, F., Solai, F., Malacrino, C., Nardo, T., Vincenzi, B., Modesti, M., & Scarpa, S. (2013). Plasma levels of matrix metalloproteinases 2 and 9 correlate with histological grade in breast cancer patients. Oncology Letters, 5, 316-320. https://doi.org/10.3892/ol.2012.977
MLA
Vasaturo, F., Solai, F., Malacrino, C., Nardo, T., Vincenzi, B., Modesti, M., Scarpa, S."Plasma levels of matrix metalloproteinases 2 and 9 correlate with histological grade in breast cancer patients". Oncology Letters 5.1 (2013): 316-320.
Chicago
Vasaturo, F., Solai, F., Malacrino, C., Nardo, T., Vincenzi, B., Modesti, M., Scarpa, S."Plasma levels of matrix metalloproteinases 2 and 9 correlate with histological grade in breast cancer patients". Oncology Letters 5, no. 1 (2013): 316-320. https://doi.org/10.3892/ol.2012.977
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