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Article

Arg399Gln polymorphism of XRCC1 gene and risk of colorectal cancer in Kashmir: A case control study

  • Authors:
    • Saniya Nissar
    • Tufail Ahmad Lone
    • Mujeeb Zafar Banday
    • Roohi Rasool
    • Nissar A. Chowdri
    • Fazl Q. Parray
    • Safiya Abdullah
    • Aga Syed Sameer
  • View Affiliations / Copyright

    Affiliations: Department of Immunology and Molecular Medicine, Kashmir University, Hazratbal, Kashmir, India, Department of General Surgery, Sher-I-Kashmir Institute of Medical Sciences, Soura, Kashmir University, Hazratbal, Kashmir, India, Department of Biotechnology, Kashmir University, Hazratbal, Kashmir, India, Department of Biochemistry, Medical College, Sher-I-Kashmir Institute of Medical Sciences, Soura, Srinagar, Kashmir, India
  • Pages: 959-963
    |
    Published online on: January 3, 2013
       https://doi.org/10.3892/ol.2013.1104
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Abstract

The aim of this study was to investigate the role of the XRCC1 Arg399Gln polymorphism in the susceptibility of a Kashmiri population to colorectal cancer (CRC). We investigated the genotype distribution of the XRCC1 gene in 130 CRC cases in comparison with that of 150 healthy subjects. There was no direct significant association between the XRCC1 genotypes and CRC; however, the Arg/Gln genotype was associated with an elevated risk of CRC (OR>1.47) and the Gln/Gln variant genotype was associated with an increased risk of CRC in various clinicopathological parameters. This study suggests that the XRCC1 polymorphism is associated with an increased risk of CRC.
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Copy and paste a formatted citation
Spandidos Publications style
Nissar S, Lone TA, Banday MZ, Rasool R, Chowdri NA, Parray FQ, Abdullah S and Sameer AS: Arg399Gln polymorphism of XRCC1 gene and risk of colorectal cancer in Kashmir: A case control study. Oncol Lett 5: 959-963, 2013.
APA
Nissar, S., Lone, T.A., Banday, M.Z., Rasool, R., Chowdri, N.A., Parray, F.Q. ... Sameer, A.S. (2013). Arg399Gln polymorphism of XRCC1 gene and risk of colorectal cancer in Kashmir: A case control study. Oncology Letters, 5, 959-963. https://doi.org/10.3892/ol.2013.1104
MLA
Nissar, S., Lone, T. A., Banday, M. Z., Rasool, R., Chowdri, N. A., Parray, F. Q., Abdullah, S., Sameer, A. S."Arg399Gln polymorphism of XRCC1 gene and risk of colorectal cancer in Kashmir: A case control study". Oncology Letters 5.3 (2013): 959-963.
Chicago
Nissar, S., Lone, T. A., Banday, M. Z., Rasool, R., Chowdri, N. A., Parray, F. Q., Abdullah, S., Sameer, A. S."Arg399Gln polymorphism of XRCC1 gene and risk of colorectal cancer in Kashmir: A case control study". Oncology Letters 5, no. 3 (2013): 959-963. https://doi.org/10.3892/ol.2013.1104
Copy and paste a formatted citation
x
Spandidos Publications style
Nissar S, Lone TA, Banday MZ, Rasool R, Chowdri NA, Parray FQ, Abdullah S and Sameer AS: Arg399Gln polymorphism of XRCC1 gene and risk of colorectal cancer in Kashmir: A case control study. Oncol Lett 5: 959-963, 2013.
APA
Nissar, S., Lone, T.A., Banday, M.Z., Rasool, R., Chowdri, N.A., Parray, F.Q. ... Sameer, A.S. (2013). Arg399Gln polymorphism of XRCC1 gene and risk of colorectal cancer in Kashmir: A case control study. Oncology Letters, 5, 959-963. https://doi.org/10.3892/ol.2013.1104
MLA
Nissar, S., Lone, T. A., Banday, M. Z., Rasool, R., Chowdri, N. A., Parray, F. Q., Abdullah, S., Sameer, A. S."Arg399Gln polymorphism of XRCC1 gene and risk of colorectal cancer in Kashmir: A case control study". Oncology Letters 5.3 (2013): 959-963.
Chicago
Nissar, S., Lone, T. A., Banday, M. Z., Rasool, R., Chowdri, N. A., Parray, F. Q., Abdullah, S., Sameer, A. S."Arg399Gln polymorphism of XRCC1 gene and risk of colorectal cancer in Kashmir: A case control study". Oncology Letters 5, no. 3 (2013): 959-963. https://doi.org/10.3892/ol.2013.1104
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