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Article

Effects of tubeimoside‑1 on the proliferation and apoptosis of BGC823 gastric cancer cells in vitro

  • Authors:
    • Yi Zhang
    • Xiao-Man Xu
    • Meng Zhang
    • Dan Qu
    • Hui-Yan Niu
    • Xue Bai
    • Liang Kan
    • Ping He
  • View Affiliations / Copyright

    Affiliations: Department of Geriatrics, Shengjing Hospital of China Medical University, Shenyang, Liaoning 110004, P.R. China, Department of Geriatrics, Shengjing Hospital of China Medical University, Shenyang, Liaoning 110004, P.R. China, Department of Respiratory Medicine, Shengjing Hospital of China Medical University, Shenyang, Liaoning 110004, P.R. China
  • Pages: 801-804
    |
    Published online on: January 8, 2013
       https://doi.org/10.3892/ol.2013.1117
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Abstract

Natural products isolated from Chinese medicinal herbs are useful sources of new drugs for cancer therapy. Tubeimoside‑1 (TBMS1) is a natural compound isolated from the Chinese medicinal herb Bolbostemma paniculatum (Maxim.) Franquet (Cucurbitaceae). Studies have shown that TBMS1 has anticancer effects in various human cancer cell lines. However, the effect of TBMS1 on human gastric cancer cells is unknown. In the present study, it was observed that TBMS1 inhibited BGC823 gastric cancer cell proliferation in a concentration‑ and time‑dependent manner. Fluorescent micros­copy and flow cytometric analysis showed that TBMS1 induced BGC823 cell apoptosis in a concentration‑dependent manner. Western blot analysis also showed that TBMS1 induced apoptosis by regulation of the Bcl‑2 gene family in BGC823 cells. These findings indicate that TBMS1 may be developed as a possible therapeutic agent for the manage­ment of gastric cancer.
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1 

Parkin DM, Bray F, Ferlay J and Pisani P: Global cancer statistics, 2002. CA Cancer J Clin. 55:74–108. 2005. View Article : Google Scholar

2 

Compare D, Rocco A and Nardone G: Risk factors in gastric cancer. Eur Rev Med Pharmacol Sci. 14:302–308. 2010.

3 

Jemal A, Siegel R, Ward E, Murray T, Xu J and Thun MJ: Cancer statistics, 2007. CA Cancer J Clin. 57:43–66. 2007. View Article : Google Scholar

4 

Li N, Fan LL, Sun GP, Wan XA, Wang ZG, Wu Q and Wang H: Paeonol inhibits tumor growth in gastric cancer in vitro and in vivo. World J Gastroenterol. 16:4483–4490. 2010. View Article : Google Scholar : PubMed/NCBI

5 

Chen J, Shi DY, Liu SL and Zhong L: Tanshinone IIA induces growth inhibition and apoptosis in gastric cancer in vitro and in vivo. Oncol Rep. 27:523–528. 2012.PubMed/NCBI

6 

Onoda C, Kuribayashi K, Nirasawa S, Tsuji N, Tanaka M, Kobayashi D and Watanabe N: (−)-Epigallocatechin-3-gallate induces apoptosis in gastric cancer cell lines by down-regulating survivin expression. Int J Oncol. 38:1403–1408. 2011.

7 

Yin Y, Chen W, Tang C, Ding H, Jang J, Weng M, Cai Y and Zou G: NF-κB, JNK and p53 pathways are involved in tubeimoside-1-induced apoptosis in HepG2 cells with oxidative stress and G2/M cell cycle arrest. Food Chem Toxicol. 49:3046–3054. 2011.

8 

Wang Y, Deng L, Zhong H, Jiang X and Chen J: Natural plant extract tubeimoside I promotes apoptosis-mediated cell death in cultured human hepatoma (HepG2) cells. Biol Pharm Bull. 34:831–838. 2011. View Article : Google Scholar : PubMed/NCBI

9 

Huang P, Yu C, Liu XQ, Ding YB, Wang YX and He JL: Cytotoxicity of tubeimoside I in human choriocarcinoma JEG-3 cells by induction of cytochrome c release and apoptosis via the mitochondrial-related signaling pathway. Int J Mol Med. 28:579–587. 2011.PubMed/NCBI

10 

Xu Y, Chiu JF, He QY and Chen F: Tubeimoside-1 exerts cytotoxicity in HeLa cells through mitochondrial dysfunction and endoplasmic reticulum stress pathways. J Proteome Res. 8:1585–1593. 2009. View Article : Google Scholar : PubMed/NCBI

11 

Chen WJ, Yu C, Yang Z, He JL, Yin J, Liu HZ, Liu HT and Wang YX: Tubeimoside-1 induces G2/M phase arrest and apoptosis in SKOV-3 cells through increase of intracellular Ca2+ and caspase-dependent signaling pathways. Int J Oncol. 40:535–543. 2012.PubMed/NCBI

12 

Zhang Y, Xu X and He P: Tubeimoside-1 inhibits proliferation and induces apoptosis by increasing the Bax to Bcl-2 ratio and decreasing COX-2 expression in lung cancer A549 cells. Mol Med Rep. 4:25–29. 2011.PubMed/NCBI

13 

Yu TX, Ma RD and Yu LJ: Structure-activity relationship of tubeimosides in anti-inflammatory, antitumor, and antitumor-promoting effects. Acta Pharmacol Sin. 22:463–468. 2001.PubMed/NCBI

14 

Zhang XH, Sun NX, Guo RX, Xing JL and Liu XN: Efficacy research of tubeimoside against the experimental herpes simplex keratitis. Rec Adv Ophthalmol. 22:373–376. 2002.(In Chinese).

15 

Li XH, Wang P, Fu ZC, et al: Effects of Bolbastemmosaponins A on immunologic functions of experimental animals. China Pharm. 9:131998.(In Chinese).

16 

Yagi Y, Fushida S, Harada S, Kinoshita J, Makino I, Oyama K, Tajima H, Fujita H, Takamura H, Ninomiya I, Fujimura T, Ohta T, Yashiro M and Hirakawa K: Effects of valproic acid on the cell cycle and apoptosis through acetylation of histone and tubulin in a scirrhous gastric cancer cell line. J Exp Clin Cancer Res. 29:1492010. View Article : Google Scholar : PubMed/NCBI

17 

Xiao R, Ferry AL and Dupont-Versteegden EE: Cell death-resistance of differentiated myotubes is associated with enhanced anti-apoptotic mechanisms compared to myoblasts. Apoptosis. 16:221–234. 2011. View Article : Google Scholar : PubMed/NCBI

18 

Hanahan D and Weinberg RA: Hallmarks of cancer: the next generation. Cell. 144:646–674. 2011. View Article : Google Scholar : PubMed/NCBI

19 

Robertson JD and Orrenius S: Molecular mechanisms of apoptosis induced by cytotoxic chemicals. Crit Rev Toxicol. 30:609–627. 2000. View Article : Google Scholar : PubMed/NCBI

20 

Tamm I, Schriever F and Dörken B: Apoptosis: implications of basic research for clinical oncology. Lancet Oncol. 2:33–42. 2001. View Article : Google Scholar : PubMed/NCBI

21 

Yu J, Zhou X, He X, Dai M and Zhang Q: Curcumin induces apoptosis involving bax/bcl-2 in human hepatoma SMMC-7721 cells. Asian Pac J Cancer Prev. 12:1925–1929. 2011.PubMed/NCBI

22 

Xu YH, Zhao LJ and Li Y: Alisol B acetate induces apoptosis of SGC7901 cells via mitochondrial and phosphatidylinositol 3-kinases/Akt signaling pathways. World J Gastroenterol. 15:2870–2877. 2009. View Article : Google Scholar : PubMed/NCBI

23 

Jiang T, Zhou L, Zhang W, Qu D, Xu X, Yang Y and Li S: Effects of sinomenine on proliferation and apoptosis in human lung cancer cell line NCI-H460 in vitro. Mol Med Rep. 3:51–56. 2010.PubMed/NCBI

24 

Xu X, Zhang Y, Qu D, Jiang T and Li S: Osthole induces G2/M arrest and apoptosis in lung cancer A549 cells by modulating PI3K/Akt pathway. J Exp Clin Cancer Res. 30:332011. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Zhang Y, Xu X, Zhang M, Qu D, Niu H, Bai X, Kan L and He P: Effects of tubeimoside‑1 on the proliferation and apoptosis of BGC823 gastric cancer cells in vitro. Oncol Lett 5: 801-804, 2013.
APA
Zhang, Y., Xu, X., Zhang, M., Qu, D., Niu, H., Bai, X. ... He, P. (2013). Effects of tubeimoside‑1 on the proliferation and apoptosis of BGC823 gastric cancer cells in vitro. Oncology Letters, 5, 801-804. https://doi.org/10.3892/ol.2013.1117
MLA
Zhang, Y., Xu, X., Zhang, M., Qu, D., Niu, H., Bai, X., Kan, L., He, P."Effects of tubeimoside‑1 on the proliferation and apoptosis of BGC823 gastric cancer cells in vitro". Oncology Letters 5.3 (2013): 801-804.
Chicago
Zhang, Y., Xu, X., Zhang, M., Qu, D., Niu, H., Bai, X., Kan, L., He, P."Effects of tubeimoside‑1 on the proliferation and apoptosis of BGC823 gastric cancer cells in vitro". Oncology Letters 5, no. 3 (2013): 801-804. https://doi.org/10.3892/ol.2013.1117
Copy and paste a formatted citation
x
Spandidos Publications style
Zhang Y, Xu X, Zhang M, Qu D, Niu H, Bai X, Kan L and He P: Effects of tubeimoside‑1 on the proliferation and apoptosis of BGC823 gastric cancer cells in vitro. Oncol Lett 5: 801-804, 2013.
APA
Zhang, Y., Xu, X., Zhang, M., Qu, D., Niu, H., Bai, X. ... He, P. (2013). Effects of tubeimoside‑1 on the proliferation and apoptosis of BGC823 gastric cancer cells in vitro. Oncology Letters, 5, 801-804. https://doi.org/10.3892/ol.2013.1117
MLA
Zhang, Y., Xu, X., Zhang, M., Qu, D., Niu, H., Bai, X., Kan, L., He, P."Effects of tubeimoside‑1 on the proliferation and apoptosis of BGC823 gastric cancer cells in vitro". Oncology Letters 5.3 (2013): 801-804.
Chicago
Zhang, Y., Xu, X., Zhang, M., Qu, D., Niu, H., Bai, X., Kan, L., He, P."Effects of tubeimoside‑1 on the proliferation and apoptosis of BGC823 gastric cancer cells in vitro". Oncology Letters 5, no. 3 (2013): 801-804. https://doi.org/10.3892/ol.2013.1117
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