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Article

Measurement of mid-arm muscle circumference and prognosis in stage IV non-small cell lung cancer patients

  • Authors:
    • Rafaela Festugatto Tartari
    • Jane Maria Ulbrich‑Kulczynski
    • Antônio Fabiano Ferreira Filho
  • View Affiliations / Copyright

    Affiliations: Department of Nutrition, Santa Casa de Misericórdia Hospital, Porto Alegre, Brazil, Department of Pathology, Hospital de Clinicas de Porto Alegre, Porto Alegre, Brazil, Department of Clinical Oncology, Oncosinos, Porto Alegre, Brazil
  • Pages: 1063-1067
    |
    Published online on: January 11, 2013
       https://doi.org/10.3892/ol.2013.1128
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Abstract

Overall survival (OS) varies widely in patients with stage IV non-small cell lung cancer (NSCLC). Strong prognostic factors are still needed to improve decision-making regarding standard treatment options, to stratify patients for inclusion in innovative therapeutic trials and to identify patients who would be best treated with palliative care rather than with systemic chemotherapy. Mid-arm muscle circumference (MAMC) is a bedside anthropometric measurement that estimates somatic protein reserve, an early indicator of nutritional depletion. This measurement is simple, non‑invasive, objective and inexpensive to perform. We evaluated MAMC as a potential prognostic factor in patients with stage IV NSCLC. A total of 56 non-selected consecutive patients with stage IV NSCLC were evaluated. The MAMC measurement results for these patients were expressed as a percentage of the expected reference values, adjusted for gender and age. Patients were categorized as normal (MAMC ≥90%) or depleted (MAMC <90%). The mean age of patients was 63 years (range 47-80), and the mean MAMC was 89 (range 66-122), with 55% of patients classified as depleted. The median OS was 6.2 months (95% CI, 5.1-7.3). In the subgroup with normal MAMC, the median OS was 10.2 months (95% CI, 9.2-11.1). In patients classified as depleted, the median OS was 5.0 months (95% CI, 4.2-5.8). The difference in OS between these two subgroups was highly significant (p<0.001 by the log-rank test; HR=0.21; 95% CI, 0.09-0.5 for patients with normal MAMC). In a multivariate analysis with Karnofsky status, age and gender as covariates, the difference in OS between the MAMC groups remained statistically significant (p<0.001, according to the Cox proportional hazards model). MAMC is a strong independent prognostic factor in stage IV NSCLC patients. Patients with MAMC <90% of the expected value had poor OS.
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1 

World Health Organization: International Agency for Research on Cancer. World Cancer Report 2008 Lyon: 2008

2 

National Cancer Institute (Brazil): Estimative 2011: Cancer Incidence in Brazil. Rio de Janeiro: 2011

3 

National Comprehensive Cancer Network: Non-small cell lung cancer. National Comprehensive Cancer Network: Clinical practice guidelines in Oncology. 2008, 1:http://www.nccn.org/professionals/physician_gls/PDF/nscl.pdf. Accessed September 25, 2009.

4 

Chlebowski RT, Palomares MD, Lillington L and Grosvenor M: Recent implications of weight loss in lung cancer management. Nutrition. 12:S43–S47. 2006.

5 

Wannamethee SG, Shaper AG, Lennon L and Whincup PH: Decreased muscle mass and increased central adiposity are independently related to mortality in older men. Am J Clin Nutr. 86:1339–1346. 2007.PubMed/NCBI

6 

National Center for Health Statistics Analytic and Reporting Guidelines: The Third National Health and Nutrition Examination Survey, NHANES III. Hyattsville (MD): 1988–1994

7 

Jamnik S, Santoro IL and Uehara C: Comparative study of prognostic factors among longer and shorter survival patients with bronchogenic carcinoma. J Pneumol. 28:245–250. 2002.

8 

Alberg AJ and Samet JM: Epidemiology of lung cancer. Chest. 23:S21–S49. 2003. View Article : Google Scholar

9 

Blot WJ and McLaughlin JK: Are women more susceptible to lung cancer? J Natl Cancer Inst. 96:812–813. 2004. View Article : Google Scholar : PubMed/NCBI

10 

Andrews S, Bloom K and Balogh JF: Lung cancer in women. Lahey Clinic experience 1957–1980. Cancer. 55:2894–2898. 1985.PubMed/NCBI

11 

Clark GM: Prognostic and predictive factors. Diseases of breast. Harris JR, Lippman ME, Morrow M and Hellman S: 1st edition. Lippincott-Raven; Philadelphia: pp. 461–470. 1996

12 

Spiegelman D, Mauser LH, Varw JH, Perry MC and Chahinian AP: Prognostic factor in small cell carcinoma of the lung: an analysis of 1521 patients. J Clin Oncol. 7:344–354. 1989.PubMed/NCBI

13 

Pater JL and Loeb M: Nonanatomic prognostic factors in carcinoma of the lung. A multivariate analysis Cancer. 50:326–331. 1982.PubMed/NCBI

14 

Lai SL and Perng RP: Impact of nutritional status on the survival of lung cancer patients. Zhonghua Yi Xue Za Zhi (Taipei). 61:134–140. 1998.PubMed/NCBI

15 

Tadokoro H: Lung cancer: consideration of 300 cases. (unpublished PhD thesis) University of Sao Paulo: School of Medicine. 1992

16 

Lam PT, Leung MW and Tse CY: Identifying prognostic factors for survival in advanced cancer patients: a prospective study. Hong Kong Med J. 6:453–459. 2007.PubMed/NCBI

17 

Batevik R, Grong K, Segadal L and Stangeland L: The female gender has a positive effect on survival independent of background life expectancy following surgical resection of primary non-small cell lung cancer: a study of absolute and relative survival over 15 years. Lung Cancer. 47:173–181. 2005.PubMed/NCBI

18 

Bain C, Feskanich D, Speizer FE, Thun M, Hertzmark E, Rosner BA, et al: Lung cancer rates in men and women with comparable histories of smoking. J Natl Cancer Inst. 96:826–834. 2004. View Article : Google Scholar : PubMed/NCBI

19 

Thomas P, Piraux M, Jacques LF and Grégore J: Clinical patterns and trends of outcome of elderly patients with bronchogenic carcinoma. Eur J Cardiothorac Surg. 13:266–274. 1998. View Article : Google Scholar : PubMed/NCBI

20 

Andreyev HJN, Norman AR, Oates J and Cunningham D: Why do patients with weight loss have a worse outcome when undergoing chemotherapy for gastrointestinal malignancies? Eur J Cancer. 34:503–509. 1998. View Article : Google Scholar

21 

Ovesen L, Hannibal J and Mortensen E: The interrelationship of weight loss, dietary intake, and quality of life in ambulatory patients with cancer of the lung, breast, and ovary. Nutr Cancer. 19:159–167. 1993. View Article : Google Scholar : PubMed/NCBI

22 

Kyle UG, Pirlich M, Schuetz T, Lochs H and Pichard C: Is nutritional depletion by nutritional risk index associated with increased length of hospital stay? A population-based study JPEN. 28:99–104. 2004.PubMed/NCBI

23 

Inui A: Cancer anorexia-cachexia syndrome: current issues in research and management. CA Cancer J Clin. 52:72–91. 2002. View Article : Google Scholar : PubMed/NCBI

24 

Inadera H, Nagai S, Dong HY and Matsushima K: Molecular analysis of lipid-depleting factor in a colon-26-inoculated cancer cachexia model. Int J Cancer. 101:37–45. 2002. View Article : Google Scholar : PubMed/NCBI

25 

Tisdale MJ: Cachexia in cancer patients. Nat Rev Cancer. 2:862–871. 2002. View Article : Google Scholar

26 

Van Halteren HK, Bongaerts GPA and Wagener DJTH: Cancer cachexia: what is known about its etiology and what should be the current treatment approach? Anticancer Res. 23:511–516. 2003.PubMed/NCBI

27 

Ischaki E, Papatheodoru G, Gaki E, Papa I, Kolouris N and Loukides S: Body mass and fat-free mass indices in COPD: relation with variables expressing disease severity. Chest. 132:164–169. 2007. View Article : Google Scholar : PubMed/NCBI

28 

Martin L, Watanabe S, Fainsinger R, Lau F, Ghosh S, Quan H, et al: Prognostic factors in patients with advanced cancer: use of the patient-generated subjective global assessment in survival prediction. J Clin Oncol. 28:4376–4383. 2010. View Article : Google Scholar : PubMed/NCBI

29 

Jamnik S, Santoro IL and Lopes I: Lung cancer evolution in accordance with the weight loss. Folha Med. 119:23–26. 2000.

30 

Uehara C, Santoro IL and Jamnik S: Lung cancer: comparison between sexes. J Pneumol. 24:347–353. 2000.

31 

Buccheri G and Ferrigno D: Importance of weight loss definition in the prognostic evaluation of non-small-cell lung cancer. Lung Cancer. 34:433–440. 2001. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Tartari RF, Ulbrich‑Kulczynski JM and Ferreira Filho AF: Measurement of mid-arm muscle circumference and prognosis in stage IV non-small cell lung cancer patients. Oncol Lett 5: 1063-1067, 2013.
APA
Tartari, R.F., Ulbrich‑Kulczynski, J.M., & Ferreira Filho, A.F. (2013). Measurement of mid-arm muscle circumference and prognosis in stage IV non-small cell lung cancer patients. Oncology Letters, 5, 1063-1067. https://doi.org/10.3892/ol.2013.1128
MLA
Tartari, R. F., Ulbrich‑Kulczynski, J. M., Ferreira Filho, A. F."Measurement of mid-arm muscle circumference and prognosis in stage IV non-small cell lung cancer patients". Oncology Letters 5.3 (2013): 1063-1067.
Chicago
Tartari, R. F., Ulbrich‑Kulczynski, J. M., Ferreira Filho, A. F."Measurement of mid-arm muscle circumference and prognosis in stage IV non-small cell lung cancer patients". Oncology Letters 5, no. 3 (2013): 1063-1067. https://doi.org/10.3892/ol.2013.1128
Copy and paste a formatted citation
x
Spandidos Publications style
Tartari RF, Ulbrich‑Kulczynski JM and Ferreira Filho AF: Measurement of mid-arm muscle circumference and prognosis in stage IV non-small cell lung cancer patients. Oncol Lett 5: 1063-1067, 2013.
APA
Tartari, R.F., Ulbrich‑Kulczynski, J.M., & Ferreira Filho, A.F. (2013). Measurement of mid-arm muscle circumference and prognosis in stage IV non-small cell lung cancer patients. Oncology Letters, 5, 1063-1067. https://doi.org/10.3892/ol.2013.1128
MLA
Tartari, R. F., Ulbrich‑Kulczynski, J. M., Ferreira Filho, A. F."Measurement of mid-arm muscle circumference and prognosis in stage IV non-small cell lung cancer patients". Oncology Letters 5.3 (2013): 1063-1067.
Chicago
Tartari, R. F., Ulbrich‑Kulczynski, J. M., Ferreira Filho, A. F."Measurement of mid-arm muscle circumference and prognosis in stage IV non-small cell lung cancer patients". Oncology Letters 5, no. 3 (2013): 1063-1067. https://doi.org/10.3892/ol.2013.1128
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