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April 2013 Volume 5 Issue 4

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Review

Expression of the PXR gene in various types of cancer and drug resistance (Review)

  • Authors:
    • Enqi Qiao
    • Minghua Ji
    • Jianzhong Wu
    • Rong Ma
    • Xiaohua Zhang
    • Yuejun He
    • Quanbin Zha
    • Xue Song
    • Li‑Wei Zhu
    • Jinhai Tang
  • View Affiliations / Copyright

    Affiliations: Department of General Surgery, Jiangsu Cancer Hospital, Affiliated to Nanjing Medical University, Nanjing 210009, P.R. China, Department of Oncology, The First Affiliated Hospital with Nanjing Medical University, Nanjing 210009, P.R. China, Department of General Surgery, Xuzhou Medical College, Xuzhou 221000, P.R. China
  • Pages: 1093-1100
    |
    Published online on: January 22, 2013
       https://doi.org/10.3892/ol.2013.1149
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Abstract

Pregnane X receptor (PXR) is a member of the nuclear receptor superfamily of ligand‑regulated transcription factors. PXR is a key xenobiotic receptor that regulates the expression of genes implicated in drug metabolism, detoxification and clearance, including drug metabolizing enzymes and transporters, suggesting that it is significant in the drug resistance of cancer cells. PXR is expressed in a wide range of tissues in the human body. Studies have demonstrated that PXR is expressed in a variety of tumor types, correlating not only with drug resistance but also with the cell proliferation, apoptosis and prognosis of cancer. The purpose of the present review is to provide a comprehensive review of PXR and its potential roles in multidrug resistance and the biological characteristics of PXR‑positive tumors.
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Copy and paste a formatted citation
Spandidos Publications style
Qiao E, Ji M, Wu J, Ma R, Zhang X, He Y, Zha Q, Song X, Zhu LW, Tang J, Tang J, et al: Expression of the PXR gene in various types of cancer and drug resistance (Review). Oncol Lett 5: 1093-1100, 2013.
APA
Qiao, E., Ji, M., Wu, J., Ma, R., Zhang, X., He, Y. ... Tang, J. (2013). Expression of the PXR gene in various types of cancer and drug resistance (Review). Oncology Letters, 5, 1093-1100. https://doi.org/10.3892/ol.2013.1149
MLA
Qiao, E., Ji, M., Wu, J., Ma, R., Zhang, X., He, Y., Zha, Q., Song, X., Zhu, L., Tang, J."Expression of the PXR gene in various types of cancer and drug resistance (Review)". Oncology Letters 5.4 (2013): 1093-1100.
Chicago
Qiao, E., Ji, M., Wu, J., Ma, R., Zhang, X., He, Y., Zha, Q., Song, X., Zhu, L., Tang, J."Expression of the PXR gene in various types of cancer and drug resistance (Review)". Oncology Letters 5, no. 4 (2013): 1093-1100. https://doi.org/10.3892/ol.2013.1149
Copy and paste a formatted citation
x
Spandidos Publications style
Qiao E, Ji M, Wu J, Ma R, Zhang X, He Y, Zha Q, Song X, Zhu LW, Tang J, Tang J, et al: Expression of the PXR gene in various types of cancer and drug resistance (Review). Oncol Lett 5: 1093-1100, 2013.
APA
Qiao, E., Ji, M., Wu, J., Ma, R., Zhang, X., He, Y. ... Tang, J. (2013). Expression of the PXR gene in various types of cancer and drug resistance (Review). Oncology Letters, 5, 1093-1100. https://doi.org/10.3892/ol.2013.1149
MLA
Qiao, E., Ji, M., Wu, J., Ma, R., Zhang, X., He, Y., Zha, Q., Song, X., Zhu, L., Tang, J."Expression of the PXR gene in various types of cancer and drug resistance (Review)". Oncology Letters 5.4 (2013): 1093-1100.
Chicago
Qiao, E., Ji, M., Wu, J., Ma, R., Zhang, X., He, Y., Zha, Q., Song, X., Zhu, L., Tang, J."Expression of the PXR gene in various types of cancer and drug resistance (Review)". Oncology Letters 5, no. 4 (2013): 1093-1100. https://doi.org/10.3892/ol.2013.1149
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