Expression of the PXR gene in various types of cancer and drug resistance (Review)

  • Authors:
    • Enqi Qiao
    • Minghua Ji
    • Jianzhong Wu
    • Rong Ma
    • Xiaohua Zhang
    • Yuejun He
    • Quanbin Zha
    • Xue Song
    • Li‑Wei Zhu
    • Jinhai Tang
  • View Affiliations

  • Published online on: January 22, 2013     https://doi.org/10.3892/ol.2013.1149
  • Pages: 1093-1100
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Abstract

Pregnane X receptor (PXR) is a member of the nuclear receptor superfamily of ligand‑regulated transcription factors. PXR is a key xenobiotic receptor that regulates the expression of genes implicated in drug metabolism, detoxification and clearance, including drug metabolizing enzymes and transporters, suggesting that it is significant in the drug resistance of cancer cells. PXR is expressed in a wide range of tissues in the human body. Studies have demonstrated that PXR is expressed in a variety of tumor types, correlating not only with drug resistance but also with the cell proliferation, apoptosis and prognosis of cancer. The purpose of the present review is to provide a comprehensive review of PXR and its potential roles in multidrug resistance and the biological characteristics of PXR‑positive tumors.
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April 2013
Volume 5 Issue 4

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Spandidos Publications style
Qiao E, Ji M, Wu J, Ma R, Zhang X, He Y, Zha Q, Song X, Zhu LW, Tang J, Tang J, et al: Expression of the PXR gene in various types of cancer and drug resistance (Review). Oncol Lett 5: 1093-1100, 2013
APA
Qiao, E., Ji, M., Wu, J., Ma, R., Zhang, X., He, Y. ... Tang, J. (2013). Expression of the PXR gene in various types of cancer and drug resistance (Review). Oncology Letters, 5, 1093-1100. https://doi.org/10.3892/ol.2013.1149
MLA
Qiao, E., Ji, M., Wu, J., Ma, R., Zhang, X., He, Y., Zha, Q., Song, X., Zhu, L., Tang, J."Expression of the PXR gene in various types of cancer and drug resistance (Review)". Oncology Letters 5.4 (2013): 1093-1100.
Chicago
Qiao, E., Ji, M., Wu, J., Ma, R., Zhang, X., He, Y., Zha, Q., Song, X., Zhu, L., Tang, J."Expression of the PXR gene in various types of cancer and drug resistance (Review)". Oncology Letters 5, no. 4 (2013): 1093-1100. https://doi.org/10.3892/ol.2013.1149