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April 2013 Volume 5 Issue 4

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International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

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International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

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Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

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Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

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Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

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Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

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International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

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Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

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International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

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Article

Effect of autophagy inhibition on chemotherapy‑induced apoptosis in A549 lung cancer cells

  • Authors:
    • Feifei Liu
    • Donglei Liu
    • Yang Yang
    • Song Zhao
  • View Affiliations / Copyright

    Affiliations: Department of Thoracic Surgery, First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, P.R. China
  • Pages: 1261-1265
    |
    Published online on: January 25, 2013
       https://doi.org/10.3892/ol.2013.1154
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Abstract

Chemotherapy is one of the main methods of cancer treatment and is known to induce autophagy in cancer cells. The main mechanism of chemotherapeutic agents is to promote apoptosis. In the process of chemotherapy, there is a unique association between autophagy and apoptosis. In this study, MDC staining, Hoechst 33342 staining and flow cytometry were used to explore the effects of autophagy on chemotherapy-induced apoptosis in A549 lung cancer cells and the association between autophagy and apoptosis was investigated via the addition of an autophagic inhibitor (3-methyladenine, 3-MA). This study demonstrated that cisplatin and paclitaxel were able to induce autophagy and apoptosis in A549 lung cancer cells and the inhibition of autophagy promoted cisplatin and paclitaxel‑induced apoptosis. Furthermore, autophagy may play a protective role in the processes of cisplatin and paclitaxel-induced apoptosis.
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Copy and paste a formatted citation
Spandidos Publications style
Liu F, Liu D, Yang Y and Zhao S: Effect of autophagy inhibition on chemotherapy‑induced apoptosis in A549 lung cancer cells. Oncol Lett 5: 1261-1265, 2013.
APA
Liu, F., Liu, D., Yang, Y., & Zhao, S. (2013). Effect of autophagy inhibition on chemotherapy‑induced apoptosis in A549 lung cancer cells. Oncology Letters, 5, 1261-1265. https://doi.org/10.3892/ol.2013.1154
MLA
Liu, F., Liu, D., Yang, Y., Zhao, S."Effect of autophagy inhibition on chemotherapy‑induced apoptosis in A549 lung cancer cells". Oncology Letters 5.4 (2013): 1261-1265.
Chicago
Liu, F., Liu, D., Yang, Y., Zhao, S."Effect of autophagy inhibition on chemotherapy‑induced apoptosis in A549 lung cancer cells". Oncology Letters 5, no. 4 (2013): 1261-1265. https://doi.org/10.3892/ol.2013.1154
Copy and paste a formatted citation
x
Spandidos Publications style
Liu F, Liu D, Yang Y and Zhao S: Effect of autophagy inhibition on chemotherapy‑induced apoptosis in A549 lung cancer cells. Oncol Lett 5: 1261-1265, 2013.
APA
Liu, F., Liu, D., Yang, Y., & Zhao, S. (2013). Effect of autophagy inhibition on chemotherapy‑induced apoptosis in A549 lung cancer cells. Oncology Letters, 5, 1261-1265. https://doi.org/10.3892/ol.2013.1154
MLA
Liu, F., Liu, D., Yang, Y., Zhao, S."Effect of autophagy inhibition on chemotherapy‑induced apoptosis in A549 lung cancer cells". Oncology Letters 5.4 (2013): 1261-1265.
Chicago
Liu, F., Liu, D., Yang, Y., Zhao, S."Effect of autophagy inhibition on chemotherapy‑induced apoptosis in A549 lung cancer cells". Oncology Letters 5, no. 4 (2013): 1261-1265. https://doi.org/10.3892/ol.2013.1154
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