Risk assessment of mouse gastric tissue cancer induced by dichlorvos and dimethoate

Wang,Qing-Lu; Zhang,Yu-Jun; Zhou,Cai-Xia; Zhang,Jie; Dou,Ye; Li,Qiao-Qiao

doi:10.3892/ol.2013.1155

April 2013 Volume 5 Issue 4

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April 2013 Volume 5 Issue 4

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Article

Risk assessment of mouse gastric tissue cancer induced by dichlorvos and dimethoate

Authors:
- Qing-Lu Wang
- Yu-Jun Zhang
- Cai-Xia Zhou
- Jie Zhang
- Ye Dou
- Qiao-Qiao Li
View Affiliations / Copyright

Affiliations: Key Laboratory of Biomedical Engineering and Technology of Shandong High School, Shandong Wanjie Medical College, Zibo 255213, P.R. China
Pages: 1385-1389
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Published online on: January 28, 2013

https://doi.org/10.3892/ol.2013.1155
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Abstract

Cancer hazards from pesticide residues in food have been much discussed in the past decade. In this study, we showed that dichlorvos and dimethoate affect hemoglobin content and hematocrit value, but had no effect on red blood cell counts and total plasma protein in mice. A 40-mg/kg/day dose of dichlorvos upregulated the expression of p16, Bcl-2 and c-myc genes in mouse gastric tissue. By contrast, expression of the p16, Bcl-2 and c-myc genes induced by low doses (5, 10 and 20 mg/kg/day) of dichlorvos demonstrated no change in the control check group (CK; 200 µl sterile saline perfused group; 0 mg/kg/day). Different doses of dimethoate all upregulated the expression of p16, Bcl-2 and c-myc genes in mouse gastric tissue. The results further demonstrated that mouse gastric tissue, exposed in the long-term to low doses of dichlorvos and dimethoate, has the potential to become cancerous.

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1	Mills PK and Yang RC: Agricultural exposures and gastric cancer risk in Hispanic farm workers in California. Environ Res. 104:282–289. 2007. View Article : Google Scholar
2	Perkins CI, Cohen R, Young JL, Schlag R and Wright WE: Cancer in California: Detailed Site and Histology, 1990–1994. Sacramento: California Cancer Registry; 1997
3	Ishmael J, MacGregor JA and Manley A: Dichlorvos - a comprehensive review of 11 rodent carcinogenicity studies. Regul Toxicol Pharmacol. 44:238–248. 2006. View Article : Google Scholar : PubMed/NCBI
4	Rawlings NC, Cook SJ and Waldbillig D: Effects of the pesticides carbofuran, chlorpyrifos, dimethoate, lindane, triallate, trifluralin, 2,4-D, and pentachlorophenol on the metabolic endocrine and reproductive endocrine system in ewes. J Toxicol Environ Health A. 54:21–36. 1998. View Article : Google Scholar
5	Begum G and Vijayaraghavan S: Alterations in protein metabolism of muscle tissue in the fish Clarias batrachus (Linn) by commercial grade dimethoate. Bull Environ Contam Toxicol. 57:223–228. 1996. View Article : Google Scholar : PubMed/NCBI
6	Institóris L, Siroki O and Dési I: Immunotoxicity study of repeated small doses of dimethoate and methylparathion administered to rats over three generations. Hum Exp Toxicol. 14:879–883. 1995.PubMed/NCBI
7	Dell’Omo G and Shore RF: Behavioral effects of acute sublethal exposure to dimethoate on wood mice, Apodemus sylvaticus: II - Field studies on radio-tagged mice in a cereal ecosystem. Arch Environ Contam Toxicol. 31:538–542. 1996.
8	Begum G and Vijayaraghavan S: In vivo toxicity of dimethoate on proteins and transaminases in the liver tissue of fresh water fish Clarias batrachus (Linn). Bull Environ Contam Toxicol. 54:370–375. 1995. View Article : Google Scholar : PubMed/NCBI
9	Silva MA, Ronconi A, Cordeiro N, et al: Blood parasites, total plasma protein and packed cell volume of small wild mammals trapped in three mountain ranges of the Atlantic Forest in Southeastern Brazil. Braz J Biol. 67:531–535. 2007.
10	Spiess BD, Ley C, Body SC, et al: Hematocrit value on intensive care unit entry influences the frequency of Q-wave myocardial infarction after coronary artery bypass grafting. The Institutions of the Multicenter Study of Perioperative Ischemia (McSPI) Research Group. J Thorac Cardiovasc Surg. 116:460–467. 1998. View Article : Google Scholar
11	Tilak KS, Veeraiah K and Raju JM: Effects of ammonia, nitrite and nitrate on hemoglobin content and oxygen consumption of freshwater fish, Cyprinus carpio (Linnaeus). J Environ Biol. 28:45–47. 2007.PubMed/NCBI
12	Applied Biosystems: User Bulletin No. 2. ABI Prism 7700 Sequence Detection System, 1997.
13	Shibata A and Parsonnet J: Stomach cancer. Cancer Epidemiology and Prevention. Schottenfeld D and Fraumeni JF: 3rd edition. Oxford University Press; New York: pp. 707–720. 2006, View Article : Google Scholar
14	Parkin DM, Bray F, Ferlay J and Pisani P: Global cancer statistics, 2002. CA Cancer J Clin. 55:74–108. 2005. View Article : Google Scholar
15	Shi J, Zhang G, Yao D, et al: Prognostic significance of aberrant gene methylation in gastric cancer. Am J Cancer Res. 2:116–129. 2012.PubMed/NCBI
16	Bashir SA, Pandith AA, Yousuf A, et al: Lack of p16 gene mutations in gastric cancers in Kashmir. Asian Pac J Cancer Prev. 11:339–342. 2010.PubMed/NCBI
17	Liu X, Cai H, Huang H, Long Z, Shi Y and Wang Y: The prognostic significance of apoptosis-related biological markers in Chinese gastric cancer patients. PLoS One. 6:e296702011. View Article : Google Scholar : PubMed/NCBI
18	Wang P, Mei J, Zhang N, Tao J, Tian H and Fu GH: Helicobacter pylori upregulates the expression of p16(INK4) in gastric cancer cells. Hepatogastroenterology. 58:846–853. 2011. View Article : Google Scholar
19	Mitomi H, Fukui N, Kishimoto I, et al: Role for p16(INK4a) in progression of gastrointestinal stromal tumors of the stomach: alteration of p16(INK4a) network members. Hum Pathol. 42:1505–1513. 2011. View Article : Google Scholar : PubMed/NCBI

Journals

International Journal of Molecular Medicine

International Journal of Oncology

Molecular Medicine Reports

Oncology Reports

Experimental and Therapeutic Medicine

Oncology Letters

Biomedical Reports

Molecular and Clinical Oncology

World Academy of Sciences Journal

International Journal of Functional Nutrition

International Journal of Epigenetics

Medicine International

Risk assessment of mouse gastric tissue cancer induced by dichlorvos and dimethoate

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