Risk assessment of mouse gastric tissue cancer induced by dichlorvos and dimethoate

Wang,Qing-Lu; Zhang,Yu-Jun; Zhou,Cai-Xia; Zhang,Jie; Dou,Ye; Li,Qiao-Qiao

doi:10.3892/ol.2013.1155

Risk assessment of mouse gastric tissue cancer induced by dichlorvos and dimethoate

Authors:
- Qing-Lu Wang
- Yu-Jun Zhang
- Cai-Xia Zhou
- Jie Zhang
- Ye Dou
- Qiao-Qiao Li
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Affiliations: Key Laboratory of Biomedical Engineering and Technology of Shandong High School, Shandong Wanjie Medical College, Zibo 255213, P.R. China
Published online on: January 28, 2013 https://doi.org/10.3892/ol.2013.1155
Pages: 1385-1389

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Abstract

Cancer hazards from pesticide residues in food have been much discussed in the past decade. In this study, we showed that dichlorvos and dimethoate affect hemoglobin content and hematocrit value, but had no effect on red blood cell counts and total plasma protein in mice. A 40-mg/kg/day dose of dichlorvos upregulated the expression of p16, Bcl-2 and c-myc genes in mouse gastric tissue. By contrast, expression of the p16, Bcl-2 and c-myc genes induced by low doses (5, 10 and 20 mg/kg/day) of dichlorvos demonstrated no change in the control check group (CK; 200 µl sterile saline perfused group; 0 mg/kg/day). Different doses of dimethoate all upregulated the expression of p16, Bcl-2 and c-myc genes in mouse gastric tissue. The results further demonstrated that mouse gastric tissue, exposed in the long-term to low doses of dichlorvos and dimethoate, has the potential to become cancerous.

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