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April 2013 Volume 5 Issue 4

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International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

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Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

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Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

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Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

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Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

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International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

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World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

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International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

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Article

Repression of Dicer is associated with invasive phenotype and chemoresistance in ovarian cancer

  • Authors:
    • Yan Kuang
    • Jing Cai
    • Donglin Li
    • Qin Han
    • Jin Cao
    • Zehua Wang
  • View Affiliations / Copyright

    Affiliations: Department of Obstetrics and Gynecology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, P.R. China
  • Pages: 1149-1154
    |
    Published online on: January 28, 2013
       https://doi.org/10.3892/ol.2013.1158
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Abstract

Dicer is a key enzyme that processes microRNA (miRNA) precursors into their mature form, enabling them to regulate gene expression. However, the effects of Dicer on the biological behavior of cancer cells remain largely unclear. In this study, it was demonstrated that Dicer downregulation promoted cell proliferation, migration and cell cycle progression in A2780 and SKOV3 ovarian cancer cells. Furthermore, Dicer expression was significantly decreased in cisplatin‑resistant A2780 cells (A2780/DDP) compared with parental A2780 cells. Knockdown of Dicer by RNA interference decreased the sensitivity of A2780 cells to cisplatin. Moreover, EZH2 depletion by short hairpin RNA (shRNA)increased the expression of Dicer in vitro. Our data suggest that Dicer is involved in numerous biological/pathological processes, including drug resistance in ovarian cancer, and that its expression may be regulated by EZH2.
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Copy and paste a formatted citation
Spandidos Publications style
Kuang Y, Cai J, Li D, Han Q, Cao J and Wang Z: Repression of Dicer is associated with invasive phenotype and chemoresistance in ovarian cancer. Oncol Lett 5: 1149-1154, 2013.
APA
Kuang, Y., Cai, J., Li, D., Han, Q., Cao, J., & Wang, Z. (2013). Repression of Dicer is associated with invasive phenotype and chemoresistance in ovarian cancer. Oncology Letters, 5, 1149-1154. https://doi.org/10.3892/ol.2013.1158
MLA
Kuang, Y., Cai, J., Li, D., Han, Q., Cao, J., Wang, Z."Repression of Dicer is associated with invasive phenotype and chemoresistance in ovarian cancer". Oncology Letters 5.4 (2013): 1149-1154.
Chicago
Kuang, Y., Cai, J., Li, D., Han, Q., Cao, J., Wang, Z."Repression of Dicer is associated with invasive phenotype and chemoresistance in ovarian cancer". Oncology Letters 5, no. 4 (2013): 1149-1154. https://doi.org/10.3892/ol.2013.1158
Copy and paste a formatted citation
x
Spandidos Publications style
Kuang Y, Cai J, Li D, Han Q, Cao J and Wang Z: Repression of Dicer is associated with invasive phenotype and chemoresistance in ovarian cancer. Oncol Lett 5: 1149-1154, 2013.
APA
Kuang, Y., Cai, J., Li, D., Han, Q., Cao, J., & Wang, Z. (2013). Repression of Dicer is associated with invasive phenotype and chemoresistance in ovarian cancer. Oncology Letters, 5, 1149-1154. https://doi.org/10.3892/ol.2013.1158
MLA
Kuang, Y., Cai, J., Li, D., Han, Q., Cao, J., Wang, Z."Repression of Dicer is associated with invasive phenotype and chemoresistance in ovarian cancer". Oncology Letters 5.4 (2013): 1149-1154.
Chicago
Kuang, Y., Cai, J., Li, D., Han, Q., Cao, J., Wang, Z."Repression of Dicer is associated with invasive phenotype and chemoresistance in ovarian cancer". Oncology Letters 5, no. 4 (2013): 1149-1154. https://doi.org/10.3892/ol.2013.1158
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