Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Oncology Letters
Join Editorial Board Propose a Special Issue
Print ISSN: 1792-1074 Online ISSN: 1792-1082
Journal Cover
April 2013 Volume 5 Issue 4

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
April 2013 Volume 5 Issue 4

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article

Overexpression of hnRNPC2 induces multinucleation by repression of Aurora B in hepatocellular carcinoma cells

  • Authors:
    • Da-Quan Sun
    • Ying Wang
    • Ding-Gan Liu
  • View Affiliations / Copyright

    Affiliations: State Key Laboratory of Molecular Biology, Institute of Biochemistry and Cell Biology, Shanghai Institute for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, P.R. China
  • Pages: 1243-1249
    |
    Published online on: January 31, 2013
       https://doi.org/10.3892/ol.2013.1167
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

Heterogeneous ribonuclear protein C2 (hnRNPC2), an RNA binding protein, is a component of hnRNPC which is upregulated in many tumors. Multinucleation exists in many tumors and is positively correlated with tumor grade. To uncover the correlation between hnRNPC2 and multinucleation in hepatocellular carcinoma SMMC-7721 cells, we constructed a pEGFP-hnRNPC2 vector and transfected it into cancer cells. Our results revealed that overexpression of hnRNPC2 induced multinucleation in SMMC-7721 cells. Tracking tests indicated that the induced multinucleated cells were unable to recover to mononuclear cells and finally died as a result of defects in cell division. Furthermore, Aurora B, which was localized at the midbody and plays a role in cytokinesis, was repressed in hnRNPC2-overexpressing cells, whose knockdown by RNA interference also induced multinucleation in SMMC-7721 cells. Quantitative polymerase chain reaction (qPCR) and mRNA-protein co-immunoprecipitation results revealed that Aurora B mRNA did not decrease in hnRNPC2-overexpressing cells, instead it bound more hnRNPC2 and less eIF4E, an mRNA cap binding protein and translational initiation factor. Moreover, hnRNPC2 bound more eIF4E in hnRNPC2-overexpressing cells. These results indicate that hnRNPC2 repressed Aurora B binding with eIF4F, which must bind with Aurora B mRNA in order to initiate its translation. This induced multinucleation in hepatocellular carcinoma cells. In addition, hnRNPC2 accelerated hepatocellular carcinoma cell proliferation. Collectively, these data suggest that hnRNPC2 may be a potential target for hepatocellular carcinoma cell diagnosis and treatment.
View Figures

Figure 1

Figure 2

Figure 3

Figure 4

Figure 5

View References

1 

Christian KJ, Lang MA and Raffalli-Mathieu F: Interaction of heterogeneous nuclear ribonucleoprotein C1/C2 with a novel cis-regulatory element within p53 mRNA as a response to cytostatic drug treatment. Mol Pharmacol. 73:1558–1567. 2008. View Article : Google Scholar

2 

Sun W, Xing B, Sun Y, et al: Proteome analysis of hepatocellular carcinoma by two-dimensional difference gel electrophoresis. Mol Cell Proteomics. 6:1798–1808. 2007. View Article : Google Scholar : PubMed/NCBI

3 

Zhang J, Cho SJ, Shu L, et al: Translational repression of p53 by RNPC1, a p53 target overexpressed in lymphomas. Genes Dev. 25:1528–1543. 2011. View Article : Google Scholar : PubMed/NCBI

4 

Merrill BM, Barnett SF, LeStourgeon WM and Williams KR: Primary structure differences between proteins Cl and C2 of HeLa 40S nuclear ribonucleoprotein particles. Nucleic Acids Res. 17:8441–8449. 1989. View Article : Google Scholar

5 

Izquierdo JM: Heterogeneous ribonucleoprotein C displays a repressor activity mediated by T-cell intracellular antigen-1-related/like protein to modulate Fas exon 6 splicing through a mechanism involving Hu antigen R. Nucleic Acids Res. 38:8001–8014. 2010. View Article : Google Scholar

6 

Nakielny S and Dreyfuss G: The hnRNP C proteins contain a nuclear retention sequence that can override nuclear export signals. J Cell Biol. 134:1365–1373. 1996. View Article : Google Scholar : PubMed/NCBI

7 

Velusamy T, Shetty P, Bhandary YP, Liu MC and Shetty S: Posttranscriptional regulation of urokinase receptor expression by heterogeneous nuclear ribonuclear protein C. Biochemistry. 47:6508–6517. 2008. View Article : Google Scholar : PubMed/NCBI

8 

Shetty S: Regulation of urokinase receptor mRNA stability by hnRNP C in lung epithelial cells. Mol Cell Biochem. 272:107–118. 2005. View Article : Google Scholar : PubMed/NCBI

9 

Lee EK, Kim HH, Kuwano Y, et al: hnRNP C promotes APP translation by competing with FMRP for APP mRNA recruitment to P bodies. Nat Struct Mol Biol. 17:732–739. 2010. View Article : Google Scholar : PubMed/NCBI

10 

Kim JH, Paek KY, Choi K, et al: Heterogeneous nuclear ribonucleoprotein C modulates translation of c-myc mRNA in a cell cycle phase-dependent manner. Mol Cell Biol. 23:708–720. 2003. View Article : Google Scholar : PubMed/NCBI

11 

Blume SW, Jackson NL, Frost AR, et al: Northwestern profiling of potential translation-regulatory proteins in human breast epithelial cells and malignant breast tissues: evidence for pathological activation of the IGF1R IRES. Exp Mol Pathol. 88:341–352. 2010. View Article : Google Scholar

12 

Hossain MN, Fuji M, Miki K, Endoh M and Ayusawa D: Downregulation of hnRNP C1/C2 by siRNA sensitizes HeLa cells to various stresses. Mol Cell Biochem. 296:151–157. 2007. View Article : Google Scholar : PubMed/NCBI

13 

Meng Z, Jackson NL, Choi H, King PH, Emanuel PD and Blume SW: Alterations in RNA-binding activities of IRES-regulatory proteins as a mechanism for physiological variability and pathological dysregulation of IGF-IR translational control in human breast tumor cells. J Cell Physiol. 217:172–183. 2008. View Article : Google Scholar

14 

Ariizumi T, Ogose A, Kawashima H, Hotta T, Umezu H and Endo N: Multinucleation followed by an acytokinetic cell division in myxofibrosarcoma with giant cell proliferation. J Exp Clin Cancer Res. 28:442009. View Article : Google Scholar : PubMed/NCBI

15 

Blanchard Z, Malik R, Mullins N, et al: Geminin overexpression induces mammary tumors via suppressing cytokinesis. Oncotarget. 2:1011–1027. 2011.PubMed/NCBI

16 

Margall-Ducos G, Celton-Morizur S, Couton D, Brégerie O and Desdouets C: Liver tetraploidization is controlled by a new process of incomplete cytokinesis. J Cell Sci. 120(Pt 20): 3633–3639. 2007. View Article : Google Scholar : PubMed/NCBI

17 

Toyoda H, Bregerie O, Vallet A, et al: Changes to hepatocyte ploidy and binuclearity profiles during human chronic viral hepatitis. Gut. 54:297–302. 2005. View Article : Google Scholar : PubMed/NCBI

18 

Studach LL, Rakotomalala L, Wang WH, et al: Polo-like kinase 1 inhibition suppresses hepatitis B virus X protein-induced transformation in an in vitro model of liver cancer progression. Hepatology. 50:414–423. 2009. View Article : Google Scholar

19 

Hsieh SY, Huang SF, Yu MC, et al: Stathmin1 overexpression associated with polyploidy, tumor-cell invasion, early recurrence, and poor prognosis in human hepatoma. Mol Carcinog. 49:476–487. 2010.PubMed/NCBI

20 

Xu Z, Ogawa H, Vagnarelli P, et al: INCENP-aurora B interactions modulate kinase activity and chromosome passenger complex localization. J Cell Biol. 187:637–653. 2009. View Article : Google Scholar : PubMed/NCBI

21 

Petsalaki E, Akoumianaki T, Black EJ, Gillespie DA and Zachos G: Phosphorylation at serine 331 is required for Aurora B activation. J Cell Biol. 195:449–466. 2011. View Article : Google Scholar : PubMed/NCBI

22 

Emanuele MJ, Lan W, Jwa M, Miller SA, Chan CS and Stukenberg PT: Aurora B kinase and protein phosphatase 1 have opposing roles in modulating kinetochore assembly. J Cell Biol. 181:241–254. 2008. View Article : Google Scholar : PubMed/NCBI

23 

Yan J, Jin S, Li J and Zhan Q: Aurora B interaction of centrosomal Nlp regulates cytokinesis. J Biol Chem. 285:40230–40239. 2010. View Article : Google Scholar : PubMed/NCBI

24 

Mora-Bermudez F, Gerlich D and Ellenberg J: Maximal chromosome compaction occurs by axial shortening in anaphase and depends on Aurora kinase. Nat Cell Biol. 9:822–831. 2007. View Article : Google Scholar : PubMed/NCBI

25 

Miyauchi K, Zhu X, Foong C, Hosoya H and Murata-Hori M: Aurora B kinase activity is required to prevent polar cortical ingression during cytokinesis. Cell Cycle. 6:2549–2553. 2007. View Article : Google Scholar : PubMed/NCBI

26 

Song SJ, Kim SJ, Song MS and Lim DS: Aurora B-mediated phosphorylation of RASSF1A maintains proper cytokinesis by recruiting Syntaxin16 to the midzone and midbody. Cancer Res. 69:8540–8544. 2009. View Article : Google Scholar : PubMed/NCBI

27 

Delaval B, Ferrand A, Conte N, et al: Aurora B -TACC1 protein complex in cytokinesis. Oncogene. 23:4516–4522. 2004. View Article : Google Scholar : PubMed/NCBI

28 

You J, Li Q, Wu C, Kim J, Ottinger M and Howley PM: Regulation of aurora B expression by the bromodomain protein Brd4. Mol Cell Biol. 29:5094–5103. 2009. View Article : Google Scholar : PubMed/NCBI

29 

Qi G, Ogawa I, Kudo Y, et al: Aurora-B expression and its correlation with cell proliferation and metastasis in oral cancer. Virchows Arch. 450:297–302. 2007. View Article : Google Scholar : PubMed/NCBI

30 

Hauf S, Cole RW, LaTerra S, et al: The small molecule Hesperadin reveals a role for Aurora B in correcting kinetochore-microtubule attachment and in maintaining the spindle assembly checkpoint. J Cell Biol. 161:281–294. 2003. View Article : Google Scholar : PubMed/NCBI

31 

Wang Y, Sun DQ and Liu DG: Tumor suppression by RNA from C/EBPβ 3′UTR through the inhibition of protein kinase Cε activity. PLoS One. 6:e165432011.

32 

Peritz T, Zeng F, Kannanayakal TJ, et al: Immunoprecipitation of mRNA-protein complexes. Nat Protoc. 1:577–580. 2006. View Article : Google Scholar : PubMed/NCBI

33 

Yanagiya A, Suyama E, Adachi H, et al: Translational homeostasis via the mRNA cap-binding protein, eIF4E. Mol Cell. May 10–2012.(Epub ahead of print).

34 

Ding ZB, Shi YH, Zhou J, et al: Association of autophagy defect with a malignant phenotype and poor prognosis of hepatocellular carcinoma. Cancer Res. 68:9167–9175. 2008. View Article : Google Scholar : PubMed/NCBI

35 

Couto SS, Griffey SM, Duarte PC and Madewell BR: Feline vaccine-associated fibrosarcoma: morphologic distinctions. Vet Pathol. 39:33–41. 2002. View Article : Google Scholar : PubMed/NCBI

36 

Ganem NJ, Storchova Z and Pellman D: Tetraploidy, aneuploidy and cancer (Review). Curr Opin Genet Dev. 17:157–162. 2007. View Article : Google Scholar

37 

Guse A, Mishima M and Glotzer M: Phosphorylation of ZEN-4/MKLP1 by aurora B regulates completion of cytokinesis. Curr Biol. 15:778–786. 2005. View Article : Google Scholar : PubMed/NCBI

38 

Capalbo L, Montembault E, Takeda T, Bassi ZI, Glover DM and D’Avino PP: The chromosomal passenger complex controls the function of endosomal sorting complex required for transport-III Snf7 proteins during cytokinesis. Open Biol. 2:1200702012. View Article : Google Scholar

39 

Xu Z, Vagnarelli P, Ogawa H, Samejima K and Earnshaw WC: Gradient of increasing Aurora B kinase activity is required for cells to execute mitosis. J Biol Chem. 285:40163–40170. 2010. View Article : Google Scholar : PubMed/NCBI

40 

Guse A, Mishima M and Glotzer M: Phosphorylation of ZEN-4/MKLP1 by aurora B regulates completion of cytokinesis. Curr Biol. 15:778–786. 2005. View Article : Google Scholar : PubMed/NCBI

41 

Baldini E, Arlot-Bonnemains Y, Mottolese M, et al: Deregulation of Aurora kinase gene expression in human testicular germ cell tumours. Andrologia. 42:260–267. 2010. View Article : Google Scholar : PubMed/NCBI

42 

Graham PL, Yanowitz JL, Penn JK, Deshpande G and Schedl P: The translation initiation factor eIF4E regulates the sex-specific expression of the master switch gene Sxl in Drosophila melanogaster. PLoS Genet. 7:e10021852011. View Article : Google Scholar : PubMed/NCBI

43 

Nasr Z, Robert F, Porco JA Jr, Muller WJ and Pelletier J: eIF4F suppression in breast cancer affects maintenance and progression. Oncogene. Apr 9–2012.(Epub ahead of print).

44 

Ilic N, Utermark T, Widlund HR and Roberts TM: PI3K-targeted therapy can be evaded by gene amplification along the MYC-eukaryotic translation initiation factor 4E (eIF4E) axis. Proc Natl Acad Sci U S A. 108:E699–708. 2011. View Article : Google Scholar : PubMed/NCBI

45 

Portella G, Passaro C and Chieffi P: Aurora B: a new prognostic marker and therapeutic target in cancer. Curr Med Chem. 18:482–496. 2011. View Article : Google Scholar : PubMed/NCBI

46 

Xie F, Lang Q, Zhou M, et al: The dietary flavonoid luteolin inhibits Aurora B kinase activity and blocks proliferation of cancer cells. Eur J Pharm Sci. 46:388–396. 2012. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Sun D, Wang Y and Liu D: Overexpression of hnRNPC2 induces multinucleation by repression of Aurora B in hepatocellular carcinoma cells. Oncol Lett 5: 1243-1249, 2013.
APA
Sun, D., Wang, Y., & Liu, D. (2013). Overexpression of hnRNPC2 induces multinucleation by repression of Aurora B in hepatocellular carcinoma cells. Oncology Letters, 5, 1243-1249. https://doi.org/10.3892/ol.2013.1167
MLA
Sun, D., Wang, Y., Liu, D."Overexpression of hnRNPC2 induces multinucleation by repression of Aurora B in hepatocellular carcinoma cells". Oncology Letters 5.4 (2013): 1243-1249.
Chicago
Sun, D., Wang, Y., Liu, D."Overexpression of hnRNPC2 induces multinucleation by repression of Aurora B in hepatocellular carcinoma cells". Oncology Letters 5, no. 4 (2013): 1243-1249. https://doi.org/10.3892/ol.2013.1167
Copy and paste a formatted citation
x
Spandidos Publications style
Sun D, Wang Y and Liu D: Overexpression of hnRNPC2 induces multinucleation by repression of Aurora B in hepatocellular carcinoma cells. Oncol Lett 5: 1243-1249, 2013.
APA
Sun, D., Wang, Y., & Liu, D. (2013). Overexpression of hnRNPC2 induces multinucleation by repression of Aurora B in hepatocellular carcinoma cells. Oncology Letters, 5, 1243-1249. https://doi.org/10.3892/ol.2013.1167
MLA
Sun, D., Wang, Y., Liu, D."Overexpression of hnRNPC2 induces multinucleation by repression of Aurora B in hepatocellular carcinoma cells". Oncology Letters 5.4 (2013): 1243-1249.
Chicago
Sun, D., Wang, Y., Liu, D."Overexpression of hnRNPC2 induces multinucleation by repression of Aurora B in hepatocellular carcinoma cells". Oncology Letters 5, no. 4 (2013): 1243-1249. https://doi.org/10.3892/ol.2013.1167
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team