Malignant transformation of residual endometriosis following hysterectomy and bilateral salpingo‑oophorectomy in a female patient from a family with hereditary non‑polyposis colorectal cancer

Chen,Yuxuan; Zhai,Yan; Jiang,Xiaoying; Zhang,Zhenyu

doi:10.3892/ol.2013.1182

Malignant transformation of residual endometriosis following hysterectomy and bilateral salpingo‑oophorectomy in a female patient from a family with hereditary non‑polyposis colorectal cancer

Authors:
- Yuxuan Chen
- Yan Zhai
- Xiaoying Jiang
- Zhenyu Zhang
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Affiliations: Beijing Chaoyang Hospital, Affiliated Hospital of Capital Medical University, Beijing, P.R. China, Beijing Youan Hospital, Affiliated Hospital of Capital Medical University, Beijing, P.R. China
Published online on: February 6, 2013 https://doi.org/10.3892/ol.2013.1182
Pages: 1253-1257

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Abstract

The aim of this study was to report a case of malignant transformation from residual endometriosis following hysterectomy and bilateral salpingo‑oophorectomy in a female patient with a positive family history of ovarian and colon cancer resulting from residual endometriosis. A 42‑year‑old female patient from a family with hereditary non‑polyposis colorectal cancer (HNPCC) diagnosed with bilateral ovarian endometriosis underwent a hysterectomy and bilateral salpingo‑oophorectomy. Two years later, the patient was diagnosed with malignant ovarian cancer. Histological examination revealed an endometrioid adenocarcinoma with transitions between endometriosis and adenocarcinoma. The patient was diagnosed with ovarian endometrioid carcinoma, at FIGO stage IIC. In future, the family history of female patients with endometriosis should be collected. The association between the malignant transformation of endometriosis and HNPCC should be studied further in a research setting.

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1	Olive DL and Schwartz LB: Endometriosis. N Engl J Med. 328:1759–1769. 1993. View Article : Google Scholar : PubMed/NCBI
2	Hacker NF, Gambone JF and Hobel CJ: Hacker and Moore’s Essentials of Obstetrics and Gynecology. 5th edition. Saunders; Philadelphia: pp. 298–304. 2010
3	Czernobilsky B: Endometriosis. Fox H and Wells M: Haines and Taylor Obstetrical and Gynaecological Pathology. 4th edition. Churchill Livingstone; Edinburgh: pp. 1043–1062. 1995
4	Benoit L, Arnould L, Cheynel N, Diane B, Causeret S, Machado A, Collin F, Fraisse J and Cuisenier J: Malignant extraovarian endometriosis: a review. Eur J Surg Oncol. 32:6–11. 2006. View Article : Google Scholar
5	Munksgaard PS and Blaakaer J: The association between endometriosis and gynecological cancers and breast cancer: a review of epidemiological data. Gynecol Oncol. 123:157–163. 2011. View Article : Google Scholar : PubMed/NCBI
6	Nishida M, Watanabe K, Sato N and Ichikawa Y: Malignant transformation of ovarian endometriosis. Gynecol Obstet Invest. 50(Suppl 1): 18–25. 2000. View Article : Google Scholar
7	Corner GW, Hu CY and Hertig AT: Ovarian carcinoma arising in endometriosis. Am J Obstet Gynecol. 59:760–774. 1950.
8	Sampson JA: Endometrial carcinoma of the ovary, arising in endometrial tissue in that organ. Arch Surg. 10:1–72. 1925. View Article : Google Scholar
9	Scott RB: Malignant changes in endometriosis. Obstet Gynecol. 2:283–289. 1953.
10	Brinton LA, Gridley G, Persson I, Baron J and Bergqvist A: Cancer risk after a hospital discharge diagnosis of endometriosis. Am J Obstet Gynecol. 176:572–579. 1997. View Article : Google Scholar : PubMed/NCBI
11	Aris A: Endometriosis-associated ovarian cancer: a ten-year cohort study of women living in the Estrie Region of Quebec, Canada. J Ovarian Res. 19. 3:22010.PubMed/NCBI
12	Xu B, Hamada S, Kusuki L, Itoh R and Kitawaki J: Possible involvement of loss of heterozygosity in malignant transformation of ovarian endometriosis. Gynecol Oncol. 120:239–246. 2011. View Article : Google Scholar : PubMed/NCBI
13	Vasen HF, Mecklin JP, Khan PM and Lynch HT: The International Collaborative Group on Hereditary Non-Polyposis Colorectal Cancer (ICG-HNPCC). Dis Colon Rectum. 34:424–425. 1991. View Article : Google Scholar : PubMed/NCBI
14	Sharma A, James M, Donaldson A and Fox R: Hereditary non-polyposis colorectal cancer syndrome: combined risk of gastrointestinal and gynaecological cancer. BJOG. 108:671–677. 2001.PubMed/NCBI
15	Allen BA and Terdiman JP: Hereditary polyposis syndromes and hereditary non-polyposis colorectal cancer. Best Pract Res Clin Gastroenterol. 17:237–258. 2003. View Article : Google Scholar : PubMed/NCBI
16	Matalliotakis IM, Cakmak H, Krasonikolakis GD, Dermitzaki D, Fragouli Y, Vlastos G and Arici A: Endometriosis related to family history of malignancies in the Yale series. Surg Oncol. 19:33–37. 2010. View Article : Google Scholar : PubMed/NCBI
17	Peltomäki P: Mutations and epimutations in the origin of cancer. Exp Cell Res. 318:299–310. 2012.
18	Vasen HF, Watson P, Mecklin JP and Lynch HT: New clinical criteria for hereditary nonpolyposis colorectal cancer (HNPCC, Lynch syndrome) proposed by the International Collaborative Group on HNPCC. Gastroenterology. 116:1453–1456. 1999. View Article : Google Scholar
19	Jass JR, Stewart SM, Stewart J and Lane MR: Hereditary non-polyposis colorectal cancer - morphologies, genes and mutations. Mutat Res. 310:125–133. 1994. View Article : Google Scholar : PubMed/NCBI
20	Sato N, Tsunoda H, Nishida M, Morishita Y, Takimoto Y, Kubo T and Noguchi M: Loss of heterozygosity on 10q23.3 and mutation of the tumor suppressor gene PTEN in benign endometrial cyst of the ovary: possible sequence progression from benign endometrial cyst to endometrioid carcinoma and clear cell carcinoma of the ovary. Cancer Res. 60:7052–7056. 2000.
21	Xu B, Hamada S, Kusuki I, Itoh R and Kitawaki J: Possible involvement of loss of heterozygosity in malignant transformation of ovarian endometriosis. Gynecol Oncol. 120:239–246. 2011. View Article : Google Scholar : PubMed/NCBI
22	Minelli L, Ceccaroni M, Ruffo G, Bruni F, Pomini P, Pontrelli G, Rolla M and Scioscia M: Laparoscopic conservative surgery for stage IV symptomatic endometriosis: short-term surgical complications. Fertil Steril. 94:1218–1222. 2010. View Article : Google Scholar : PubMed/NCBI
23	Fedele L, Bianchi S, Zanconato G, Bergamini V, Berlanda N and Carmignani L: Long-term follow-up after conservative surgery for bladder endometriosis. Fertil Steril. 83:1729–1733. 2005. View Article : Google Scholar : PubMed/NCBI
24	Achard JM, Fournier A, Mazouz H, Caride VJ, Penar PL and Fernandez LA: Protection against ischemia: a physiological function of the renin-angiotensin system. Biochem Pharmacol. 62:261–271. 2001. View Article : Google Scholar : PubMed/NCBI
25	Nezhat F, Datta MS, Hanson V, Pejovic T and Nezhat C and Nezhat C: The relationship of endometriosis and ovarian malignancy: a review. Fertil Steril. 90:1559–1570. 2008. View Article : Google Scholar : PubMed/NCBI
26	Somigliana E, Vigano P, Parazzini F, Stoppelli S, Giambattista E and Vercellini P: Association between endometriosis and cancer: a comprehensive review and a critical analysis of clinical and epidemiological evidence. Gynecol Oncol. 101:331–341. 2006. View Article : Google Scholar : PubMed/NCBI