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Oncology Letters
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Print ISSN: 1792-1074 Online ISSN: 1792-1082
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April 2013 Volume 5 Issue 4

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International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

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Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

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Case Report

Temsirolimus in overtreated metastatic renal cancer with subsequent use of sunitinib: A case report

  • Authors:
    • José Miguel Jurado
    • Irene Zarcos
    • Mayte Delgado
    • Isabel Blancas
    • Marta Legerén
    • José Luis García-Puche

  • View Affiliations / Copyright

    Affiliations: Oncology Department, Hospital Clínico Universitario San Cecilio, Avenida, Granada 18012, Spain
  • Pages: 1382-1384
    |
    Published online on: February 7, 2013
       https://doi.org/10.3892/ol.2013.1184
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Abstract

During the last decade, we have been developing new therapeutic strategies for the treatment of renal cancer, based on knowledge derived from molecular biology. We report a case of long-term renal metastatic cancer progression despite therapy with sunitinib and interleukin, which are the most active drugs in renal cancer. Disease stabilization for 58 weeks was achieved upon sequential use of temsirolimus, following the occurrence of disease progression during angiogenic therapy. The patient demonstrated excellent tolerance without marked symptoms for 10 months. Hypothyroidism and mumps-related adverse events were present. The survival time from diagnosis to lung metastasis was 8 years. Thus, this case demonstrates promising therapeutic effects of the sequential use of tyrosine kinase inhibitors (TKIs) and mammalian target of rapamycin (mTOR) inhibitors during different stages of the disease.
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Copy and paste a formatted citation
Spandidos Publications style
Jurado JM, Zarcos I, Delgado M, Blancas I, Legerén M and García-Puche JL: Temsirolimus in overtreated metastatic renal cancer with subsequent use of sunitinib: A case report. Oncol Lett 5: 1382-1384, 2013.
APA
Jurado, J.M., Zarcos, I., Delgado, M., Blancas, I., Legerén, M., & García-Puche, J.L. (2013). Temsirolimus in overtreated metastatic renal cancer with subsequent use of sunitinib: A case report. Oncology Letters, 5, 1382-1384. https://doi.org/10.3892/ol.2013.1184
MLA
Jurado, J. M., Zarcos, I., Delgado, M., Blancas, I., Legerén, M., García-Puche, J. L."Temsirolimus in overtreated metastatic renal cancer with subsequent use of sunitinib: A case report". Oncology Letters 5.4 (2013): 1382-1384.
Chicago
Jurado, J. M., Zarcos, I., Delgado, M., Blancas, I., Legerén, M., García-Puche, J. L."Temsirolimus in overtreated metastatic renal cancer with subsequent use of sunitinib: A case report". Oncology Letters 5, no. 4 (2013): 1382-1384. https://doi.org/10.3892/ol.2013.1184
Copy and paste a formatted citation
x
Spandidos Publications style
Jurado JM, Zarcos I, Delgado M, Blancas I, Legerén M and García-Puche JL: Temsirolimus in overtreated metastatic renal cancer with subsequent use of sunitinib: A case report. Oncol Lett 5: 1382-1384, 2013.
APA
Jurado, J.M., Zarcos, I., Delgado, M., Blancas, I., Legerén, M., & García-Puche, J.L. (2013). Temsirolimus in overtreated metastatic renal cancer with subsequent use of sunitinib: A case report. Oncology Letters, 5, 1382-1384. https://doi.org/10.3892/ol.2013.1184
MLA
Jurado, J. M., Zarcos, I., Delgado, M., Blancas, I., Legerén, M., García-Puche, J. L."Temsirolimus in overtreated metastatic renal cancer with subsequent use of sunitinib: A case report". Oncology Letters 5.4 (2013): 1382-1384.
Chicago
Jurado, J. M., Zarcos, I., Delgado, M., Blancas, I., Legerén, M., García-Puche, J. L."Temsirolimus in overtreated metastatic renal cancer with subsequent use of sunitinib: A case report". Oncology Letters 5, no. 4 (2013): 1382-1384. https://doi.org/10.3892/ol.2013.1184
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