1
|
Semenza GL and Wang GL: A nuclear factor
induced by hypoxia via de novo protein synthesis binds to the human
erythropoietin gene enhancer at a site required for transcriptional
activation. Mol Cell Biol. 12:5447–5454. 1992.
|
2
|
Iyer NV, Kotch LE, Agani F, et al:
Cellular and developmental control of O2 homeostasis by hypoxia
inducible factor 1 alpha. Genes Dev. 12:149–162. 1998. View Article : Google Scholar : PubMed/NCBI
|
3
|
Bruick RK and McKnight SL: A conserved
family of prolyl-4-hydroxylases that modify HIF. Science.
294:1337–1340. 2001. View Article : Google Scholar : PubMed/NCBI
|
4
|
Wang GL, Jiang BH, Rue EA and Semenza GL:
Hypoxiainducible factor 1 is a basic-helix-loop-helix-PAS
heterodimer regulated by cellular O2 tension. Proc Natl Acad Sci
USA. 92:5510–5514. 1995. View Article : Google Scholar : PubMed/NCBI
|
5
|
Nakayama K, Kanzaki A, Hata K, Katabuchi
H, Okamura H, Miyazaki K, Fukumoto M and Takebayashi Y:
Hypoxia-inducible factor 1 alpha (HIF-1 alpha) gene expression in
human ovarian carcinoma. Cancer Lett. 176:215–223. 2002. View Article : Google Scholar : PubMed/NCBI
|
6
|
Lee CH, Lee MK, Kang CD, Kim YD, Park do
Y, Kim JY, Sol MY and Suh KS: Differential expression of hypoxia
inducible factor-1 alpha and tumor cell proliferation between
squamous cell carcinomas and adenocarcinomas among operable
non-small cell lung carcinomas. J Korean Med Sci. 18:196–203. 2003.
View Article : Google Scholar
|
7
|
Beasley NJ, Leek R, Alam M, Turley H, Cox
GJ, Gatter K, Millard P, Fuggle S and Harris AL: Hypoxia-inducible
factors HIF-1alpha and HIF-2 alpha in head and neck cancer:
relationship to tumor biology and treatment outcome in surgically
resected patients. Cancer Res. 62:2493–2497. 2002.PubMed/NCBI
|
8
|
Bos R, Van Der Groep P, Greijer AE,
Shvarts A, Meijer S, Pinedo HM, Semenza GL, Van Diest PJ and Van
Der Wall E: Levels of hypoxia inducible factor-1alpha independently
predict prognosis in patients with lymph node negative breast
carcinoma. Cancer. 97:1573–1581. 2003. View Article : Google Scholar : PubMed/NCBI
|
9
|
Semenza GL: Targeting HIF-1 for cancer
therapy. Nat Rev Cancer. 3:721–732. 2003. View Article : Google Scholar
|
10
|
Zhang Q, Zhang ZF, Rao JY, et al:
Treatment with siRNA and antisense oligonucleotides targeted to
HIF-1 alpha induced apoptosis in human tongue squamous cell
carcinomas. Int J Cancer. 111:849–857. 2004. View Article : Google Scholar : PubMed/NCBI
|
11
|
Cohen NA, Lai SY, Ziober AF and Ziober BL:
Dysregulation of hypoxia inducible factor-1α in head and neck
squamous cell carcinoma cell lines correlates with invasive
potential. Laryngoscope. 114:418–423. 2004.
|
12
|
Liang X, Yang D, Hu J, Hao X, Gao J and
Mao Z: Hypoxia inducible factor-α expression correlates with
vascular endothelial growth factor-C expression and
lymphangiogenesis/angiogenesis in oral squamous cell carcinoma.
Anticancer Res. 28:1659–1666. 2008.
|
13
|
Yao H, Wang H, Zhang Z, Jiang BH, Luo J
and Shi X: Sulforaphane inhibited expression of hypoxia-inducible
factor-1α in human tongue squamous cancer cells and prostate cancer
cells. Int J Cancer. 123:1255–1261. 2008.
|
14
|
Lin PY, Yu CH, Wang JT, et al: Expression
of hypoxia-inducible factor-1 alpha is significantly associated
with the progression and prognosis of oral squamous cell carcinomas
in Taiwan. J Oral Pathol Med. 37:18–25. 2008. View Article : Google Scholar : PubMed/NCBI
|
15
|
Sasabe E, Zhou X, Li D, Oku N, Yamamoto T
and Osaki T: The involvement of hypoxia-inducible factor-1α in the
susceptibility to γ-rays and chemotherapeutic drugs of oral
squamous cell carcinoma cells. Int J Cancer. 120:268–277. 2007.
|
16
|
Fillies T, Werkmeister R, van Diest PJ,
Brandt B, Joos U and Buerger H: HIF-1α overexpression indicates a
good prognosis in early stage squamous cell carcinomas of the oral
floor. BMC Cancer. 5:842005.
|
17
|
Roh JL, Cho KJ, Kwon GY, et al: The
prognostic value of hypoxia markers in T2-staged oral tongue
cancer. Oral Oncol. 45:63–68. 2009. View Article : Google Scholar : PubMed/NCBI
|
18
|
Winter SC, Shah KA, Han C, et al: The
relation between hypoxiainducible factor (HIF)-1α and HIF-2α
expression with anemia and outcome in surgically treated head and
neck cancer. Cancer. 107:757–766. 2006.
|
19
|
Carroll VA and Ashcroft M: Role of
hypoxia-inducible factor (HIF)-1α versus HIF-2α in the regulation
of HIF target genes in response to hypoxia, insulin-like growth
factor-I, or loss of von Hippel-Lindau function: implications for
targeting the HIF pathway. Cancer Res. 66:6264–6270. 2006.
|
20
|
Imamura T, Kikuchi H, Herraiz MT, et al:
HIF-1α and HIF-2α have divergent roles in colon cancer. Int J
Cancer. 124:763–771. 2009.
|
21
|
Kung AL, Zabludoff SD, France DS, et al:
Small molecule blockade of transcriptional coactivation of the
hypoxia-inducible factor pathway. Cancer Cell. 6:33–43. 2004.
View Article : Google Scholar : PubMed/NCBI
|
22
|
Li L, Lin X, Staver M, et al: Evaluating
hypoxia-inducible factor-1alpha as a cancer therapeutic target via
inducible RNA interference in vivo. Cancer Res. 65:7249–7258. 2005.
View Article : Google Scholar : PubMed/NCBI
|
23
|
Rapisarda A, Shoemaker RH and Melillo G:
Targeting topoisomerase I to inhibit hypoxia inducible factor 1.
Cell Cycle. 3:172–175. 2004. View Article : Google Scholar : PubMed/NCBI
|
24
|
Raval RR, Lau KW, Tran MG, et al:
Contrasting properties of hypoxia-inducible factor 1 (HIF-1) and
HIF-2 in von Hippel-Lindau-associated renal cell carcinoma. Mol
Cell Biol. 25:5675–86. 2005. View Article : Google Scholar : PubMed/NCBI
|
25
|
Scortegagna M, Martin RJ, Kladney RD,
Neumann RG and Arbeit JM: Hypoxia-inducible factor-1α suppresses
squamous carcinogenic progression and epithelial-mesenchymal
transition. Cancer Res. 69:2638–2646. 2009.
|