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Article

Overexpression of S100A4 is closely associated with the progression and prognosis of gastric cancer in young patients

  • Authors:
    • Hua Li
    • Ziquan Liu
    • Chuanxiang Xu
    • Yunyun Chen
    • Jianwei Zhang
    • Bo Cui
    • Xuewei Chen
    • Gaihong An
    • Xiaojun She
    • Hongtao Liu
    • Zifeng Jiang
    • Tianhui Wang

  • View Affiliations / Copyright

    Affiliations: Endoscopy Division, Tianjin Medical University Cancer Hospital and City Key Laboratory of Tianjin Cancer Center, Tianjin 300060, P.R. China, Institute of Health and Environmental Medicine, Tianjin 300050, P.R. China, Institute of Zoology, Chinese Academy of Sciences, Chaoyang, Beijing 100101, P.R. China
  • Pages: 1485-1490
    |
    Published online on: February 28, 2013
       https://doi.org/10.3892/ol.2013.1220
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Abstract

The aim of this study was to determine the correlation of S100A4 expression with the progression, prognosis and clinical pathology of gastric cancer (GC) in young pateints. A total of 85 tumor tissues with corresponding adjacent normal tissues and 62 non‑metastatic lymph nodes (LNs) with corresponding metastatic LNs were obtained from young GC patients (<40 years old) who underwent surgery between January 2001 and December 2006. The expression of S100A4 was detected by RT‑PCR and immunohistochemistry. Differences in the expression of S100A4 mRNA or protein were observed among the GC tissues, matched normal gastric mucosa, non‑metastatic LNs and metastatic LNs. The expression of S100A4 mRNA and protein in GC tissues and metastatic LNs was significantly higher compared with that in the matched normal gastric mucosa and non‑metastatic LNs, respectively (P<0.05). The overexpression of S100A4 was significantly associated with parameters involved in tumor progression and poor prognosis, including tumor size (P=0.017), Lauren classification (P=0.002), histological classification (P=0.010), histological differentiation (P=0.000), Borrmann classification (P=0.020), tumor‑node‑metastasis (TNM) stage (P=0.000), LN metastasis (P=0.000) and distant metastasis (P=0.024). Multivariate analysis suggested that patient age (P=0.035), tumor size (P=0.002), TNM stage (P=0.001) and S100A4 upregulation (P=0.000) were independent prognostic indicators for the disease. The overexpression of S100A4 in young GC patients is significantly associated with the clinicopathological characteristics. S100A4 may be used as a biomarker to predict the progression and poor prognosis of GC in young patients.
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Copy and paste a formatted citation
Spandidos Publications style
Li H, Liu Z, Xu C, Chen Y, Zhang J, Cui B, Chen X, An G, She X, Liu H, Liu H, et al: Overexpression of S100A4 is closely associated with the progression and prognosis of gastric cancer in young patients. Oncol Lett 5: 1485-1490, 2013.
APA
Li, H., Liu, Z., Xu, C., Chen, Y., Zhang, J., Cui, B. ... Wang, T. (2013). Overexpression of S100A4 is closely associated with the progression and prognosis of gastric cancer in young patients. Oncology Letters, 5, 1485-1490. https://doi.org/10.3892/ol.2013.1220
MLA
Li, H., Liu, Z., Xu, C., Chen, Y., Zhang, J., Cui, B., Chen, X., An, G., She, X., Liu, H., Jiang, Z., Wang, T."Overexpression of S100A4 is closely associated with the progression and prognosis of gastric cancer in young patients". Oncology Letters 5.5 (2013): 1485-1490.
Chicago
Li, H., Liu, Z., Xu, C., Chen, Y., Zhang, J., Cui, B., Chen, X., An, G., She, X., Liu, H., Jiang, Z., Wang, T."Overexpression of S100A4 is closely associated with the progression and prognosis of gastric cancer in young patients". Oncology Letters 5, no. 5 (2013): 1485-1490. https://doi.org/10.3892/ol.2013.1220
Copy and paste a formatted citation
x
Spandidos Publications style
Li H, Liu Z, Xu C, Chen Y, Zhang J, Cui B, Chen X, An G, She X, Liu H, Liu H, et al: Overexpression of S100A4 is closely associated with the progression and prognosis of gastric cancer in young patients. Oncol Lett 5: 1485-1490, 2013.
APA
Li, H., Liu, Z., Xu, C., Chen, Y., Zhang, J., Cui, B. ... Wang, T. (2013). Overexpression of S100A4 is closely associated with the progression and prognosis of gastric cancer in young patients. Oncology Letters, 5, 1485-1490. https://doi.org/10.3892/ol.2013.1220
MLA
Li, H., Liu, Z., Xu, C., Chen, Y., Zhang, J., Cui, B., Chen, X., An, G., She, X., Liu, H., Jiang, Z., Wang, T."Overexpression of S100A4 is closely associated with the progression and prognosis of gastric cancer in young patients". Oncology Letters 5.5 (2013): 1485-1490.
Chicago
Li, H., Liu, Z., Xu, C., Chen, Y., Zhang, J., Cui, B., Chen, X., An, G., She, X., Liu, H., Jiang, Z., Wang, T."Overexpression of S100A4 is closely associated with the progression and prognosis of gastric cancer in young patients". Oncology Letters 5, no. 5 (2013): 1485-1490. https://doi.org/10.3892/ol.2013.1220
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