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Article

Anticancer effects of 4-vinyl-2,6-dimethoxyphenol (canolol) against SGC-7901 human gastric carcinoma cells

  • Authors:
    • Jing Jiang
    • Dong-Hui Cao
    • Tetsuya Tsukamoto
    • Guo‑Qing Wang
    • Zhi-Fang Jia
    • Jian Suo
    • Xue-Yuan Cao
  • View Affiliations / Copyright

    Affiliations: Division of Clinical Epidemiology, First Hospital of Jilin University, Changchun, Jilin 130021, P.R. China, Division of Pathology, School of Medicine, Fujita Health University, Toyoake, Japan, Department of Pathogeny Biology, Norman Bethune Medical College of Jilin University, Changchun, Jilin 130021, P.R. China, Department of Gastric and Colorectal Surgery, First Hospital of Jilin University, Changchun, Jilin 130021, P.R. China
  • Pages: 1562-1566
    |
    Published online on: March 5, 2013
       https://doi.org/10.3892/ol.2013.1230
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Abstract

Gastric cancer remains the fourth most commonly diagnosed cancer and is the second leading cause of cancer-related mortality worldwide. The aim of this study was to investigate the effects of canolol on the proliferation and apoptosis of SGC-7901 human gastric cancer cells and its relevant molecular mechanisms. The 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay was used to observe the effect of canolol on the proliferation of SGC-7901 human gastric adenocarcinoma cells. The results showed that SGC-7901 cells exhibited a marked dose-dependent reduction in the proliferation rate. The survival rate of the cells was 88.86±1.58% at 50 µmol/l, decreasing to 53.73±1.51% at 800 µmol/l (P<0.05). By contrast, canolol had no significant toxicity on the human gastric mucosal epithelial cell line GES-1. The vivid images of cell morphology using an inverted microscope provided confirmation of the MTT assay. Treatment of SGC-7901 cells with canolol resulted in apoptosis demonstrated by flow cytometry. Furthermore, canolol downregulated the mRNA levels of COX-2, but had no significant effect on the mRNA expession of the Bax and Bcl-2 genes. These findings suggest that canolol has potential to be developed as a new natural anti-gastric carcinoma agent.
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Copy and paste a formatted citation
Spandidos Publications style
Jiang J, Cao D, Tsukamoto T, Wang GQ, Jia Z, Suo J and Cao X: Anticancer effects of 4-vinyl-2,6-dimethoxyphenol (canolol) against SGC-7901 human gastric carcinoma cells. Oncol Lett 5: 1562-1566, 2013.
APA
Jiang, J., Cao, D., Tsukamoto, T., Wang, G., Jia, Z., Suo, J., & Cao, X. (2013). Anticancer effects of 4-vinyl-2,6-dimethoxyphenol (canolol) against SGC-7901 human gastric carcinoma cells. Oncology Letters, 5, 1562-1566. https://doi.org/10.3892/ol.2013.1230
MLA
Jiang, J., Cao, D., Tsukamoto, T., Wang, G., Jia, Z., Suo, J., Cao, X."Anticancer effects of 4-vinyl-2,6-dimethoxyphenol (canolol) against SGC-7901 human gastric carcinoma cells". Oncology Letters 5.5 (2013): 1562-1566.
Chicago
Jiang, J., Cao, D., Tsukamoto, T., Wang, G., Jia, Z., Suo, J., Cao, X."Anticancer effects of 4-vinyl-2,6-dimethoxyphenol (canolol) against SGC-7901 human gastric carcinoma cells". Oncology Letters 5, no. 5 (2013): 1562-1566. https://doi.org/10.3892/ol.2013.1230
Copy and paste a formatted citation
x
Spandidos Publications style
Jiang J, Cao D, Tsukamoto T, Wang GQ, Jia Z, Suo J and Cao X: Anticancer effects of 4-vinyl-2,6-dimethoxyphenol (canolol) against SGC-7901 human gastric carcinoma cells. Oncol Lett 5: 1562-1566, 2013.
APA
Jiang, J., Cao, D., Tsukamoto, T., Wang, G., Jia, Z., Suo, J., & Cao, X. (2013). Anticancer effects of 4-vinyl-2,6-dimethoxyphenol (canolol) against SGC-7901 human gastric carcinoma cells. Oncology Letters, 5, 1562-1566. https://doi.org/10.3892/ol.2013.1230
MLA
Jiang, J., Cao, D., Tsukamoto, T., Wang, G., Jia, Z., Suo, J., Cao, X."Anticancer effects of 4-vinyl-2,6-dimethoxyphenol (canolol) against SGC-7901 human gastric carcinoma cells". Oncology Letters 5.5 (2013): 1562-1566.
Chicago
Jiang, J., Cao, D., Tsukamoto, T., Wang, G., Jia, Z., Suo, J., Cao, X."Anticancer effects of 4-vinyl-2,6-dimethoxyphenol (canolol) against SGC-7901 human gastric carcinoma cells". Oncology Letters 5, no. 5 (2013): 1562-1566. https://doi.org/10.3892/ol.2013.1230
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