Extrapancreatic solid pseudopapillary neoplasm: Report of a case of primary retroperitoneal origin and review of the literature

Zhu,Hejia; Xia,Dan; Wang,Bo; Meng,Hongzhou

doi:10.3892/ol.2013.1242

Extrapancreatic solid pseudopapillary neoplasm: Report of a case of primary retroperitoneal origin and review of the literature

Authors:
- Hejia Zhu
- Dan Xia
- Bo Wang
- Hongzhou Meng
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Affiliations: Department of Urology, The First Affiliated Hospital of Zhejiang University, Hangzhou, Zhejiang 310003, P.R. China, Department of Pathology, The First Affiliated Hospital of Zhejiang University, Hangzhou, Zhejiang 310003, P.R. China
Published online on: March 11, 2013 https://doi.org/10.3892/ol.2013.1242
Pages: 1501-1504

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Abstract

Solid pseudopapillary tumors (SPTs) occurring as primary tumors outside the pancreas are exceedingly rare. The present study reports such a case occurring as a non‑functional adrenal tumor in a 22‑year‑old female. The tumor was completely removed from the retroperitoneum by laparoscopic surgery. A well‑deﬁned, encapsulated tumor measuring 6x6x5 cm was histologically characterized by a combination of the solid and pseudopapillary growth patterns of tumor cells with eosinophilic cytoplasm. Ectopic pancreatic tissue was also found histologically within the resected tumor. On immunostaining, the tumor was positive for progesterone receptor, CD56, cytokeratin and CD10. The morphological and immunohistochemical features were compatible with those of SPT. To the best of our knowledge, this is the first case report of extrapancreatic SPT with evidence of a pre‑existing ectopic pancreas in the retroperitoneum. A review of the published English literature uncovered 12 cases of extrapancreatic SPTs, and revealed that extrapancreatic SPTs are likely to have a favorable clinical course and a clinical proﬁle similar to their pancreatic counterparts.

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