Autologous immune enhancement therapy against an advanced epithelioid sarcoma: A case report

Ratnavelu,Kananathan; Subramani,Baskar; Pullai,Chithra  Ramanathan; Krishnan,Kohila; Sugadan,Sheela  Devi; Rao,Manjunath  Sadananda; Veerakumarasivam,Abhi; Deng,Xuewen; Hiroshi,Terunuma

doi:10.3892/ol.2013.1247

May 2013 Volume 5 Issue 5

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May 2013 Volume 5 Issue 5

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Case Report

Autologous immune enhancement therapy against an advanced epithelioid sarcoma: A case report

Authors:
- Kananathan Ratnavelu
- Baskar Subramani
- Chithra Ramanathan Pullai
- Kohila Krishnan
- Sheela Devi Sugadan
- Manjunath Sadananda Rao
- Abhi Veerakumarasivam
- Xuewen Deng
- Terunuma Hiroshi
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Affiliations: Nilai Cancer Institute (NCI) Hospital, Nilai 71800, Malaysia, Acharya Nagarjuna University, Andhra Pradesh 522510, India, Nichi-Asia Life Science Sdn. Bhd., Petaling Jaya 47810, Malaysia, Medical Genetics Laboratory, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, Serdang 43400, Selangor Darul Ehsan, Malaysia, Nichi-In Centre for Regenerative Medicine, Chennai 600026, India, UPM-MAKNA Cancer Research Laboratory, Institute of Bioscience, Universiti Putra Malaysia, Serdang, 43400, Selangor Darul Ehsan, Malaysia, Perdana University Graduate School of Medicine, Perdana University, Serdang 43400, Selangor Darul Ehsan, Malaysia, Biotherapy Institute of Japan, Tokyo 135-0051, Japan
Pages: 1457-1460
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Published online on: March 12, 2013

https://doi.org/10.3892/ol.2013.1247
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Abstract

Rare types of cancer are often not effectively treated by approaches such as chemotherapy and radiotherapy, although their side-effects persist. Immunotherapy has been gaining attention worldwide with growing examples of its anticancer activity demonstrated in vivo. This case report describes a 35‑year‑old male who suffered from advanced epithelioid sarcoma and underwent 18 cycles of chemotherapy without any significant response, who suffered adverse effects that caused lung collapse. A notable response was observed following the administration of autologous immune enhancement therapy (AIET), which involves a process of isolation, activation and expansion of natural killer (NK) and T cells, which were obtained from the patient's own (autologous) peripheral blood. With the present data and the response of the patient to AIET, it may be proposed that AIET is beneficial for patients suffering from advanced epithelioid sarcoma without producing adverse effects.

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Journals

International Journal of Molecular Medicine

International Journal of Oncology

Molecular Medicine Reports

Oncology Reports

Experimental and Therapeutic Medicine

Oncology Letters

Biomedical Reports

Molecular and Clinical Oncology

World Academy of Sciences Journal

International Journal of Functional Nutrition

International Journal of Epigenetics

Medicine International

Autologous immune enhancement therapy against an advanced epithelioid sarcoma: A case report

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