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Article

Chemotherapy for gliomas in mainland China: An overview

  • Authors:
    • Ke Sai
    • Qun-Ying Yang
    • Dong Shen
    • Zhong-Ping Chen
  • View Affiliations / Copyright

    Affiliations: Department of Neurosurgery/Neuro-Oncology, Sun Yat-Sen University Cancer Center, State Key Laboratory of Oncology in South China, Guangzhou 510060, P.R. China
  • Pages: 1448-1452
    |
    Published online on: March 19, 2013
       https://doi.org/10.3892/ol.2013.1264
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Abstract

Chemotherapy is currently the standard treatment modality for malignant gliomas. Many patients with gliomas are treated in mainland China every year. The history and development of chemotherapy for glioma, however, are not well documented. In this study, an extensive literature search of Pubmed and major Chinese electronic databases was performed to identify clinical studies. A total of 210 publications were identified, with a total of 10,105 patients. Among these studies, 76.2% were retrospective and 23.8% were prospective. Chemotherapy was found to have been administered by the Department of Neurosurgery in 143 studies (68.1%). Oral or intravenous administration was found in 55.7% of studies, followed by intra-arterial (26.7%) and interstitial (15.7%) chemotherapy. Nitrosoureas were the most frequently used chemotherapeutic agents, as found in 133 studies (63.3%). Since 2003, 56 studies on temozolomide (TMZ) have been published. Studies on chemotherapy for gliomas began in the 1970s in mainland China but well-designed randomized controlled trials (RCTs) are rare. Much effort and collaboration should be made to carry out high-quality multicenter RCTs on chemotherapy for gliomas.
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Copy and paste a formatted citation
Spandidos Publications style
Sai K, Yang Q, Shen D and Chen Z: Chemotherapy for gliomas in mainland China: An overview. Oncol Lett 5: 1448-1452, 2013.
APA
Sai, K., Yang, Q., Shen, D., & Chen, Z. (2013). Chemotherapy for gliomas in mainland China: An overview. Oncology Letters, 5, 1448-1452. https://doi.org/10.3892/ol.2013.1264
MLA
Sai, K., Yang, Q., Shen, D., Chen, Z."Chemotherapy for gliomas in mainland China: An overview". Oncology Letters 5.5 (2013): 1448-1452.
Chicago
Sai, K., Yang, Q., Shen, D., Chen, Z."Chemotherapy for gliomas in mainland China: An overview". Oncology Letters 5, no. 5 (2013): 1448-1452. https://doi.org/10.3892/ol.2013.1264
Copy and paste a formatted citation
x
Spandidos Publications style
Sai K, Yang Q, Shen D and Chen Z: Chemotherapy for gliomas in mainland China: An overview. Oncol Lett 5: 1448-1452, 2013.
APA
Sai, K., Yang, Q., Shen, D., & Chen, Z. (2013). Chemotherapy for gliomas in mainland China: An overview. Oncology Letters, 5, 1448-1452. https://doi.org/10.3892/ol.2013.1264
MLA
Sai, K., Yang, Q., Shen, D., Chen, Z."Chemotherapy for gliomas in mainland China: An overview". Oncology Letters 5.5 (2013): 1448-1452.
Chicago
Sai, K., Yang, Q., Shen, D., Chen, Z."Chemotherapy for gliomas in mainland China: An overview". Oncology Letters 5, no. 5 (2013): 1448-1452. https://doi.org/10.3892/ol.2013.1264
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