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June 2013 Volume 5 Issue 6

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International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

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International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

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Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

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Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

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Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

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Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

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International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

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Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

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International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

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International Journal of Epigenetics

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Article

Aberrant expression of the PHF14 gene in biliary tract cancer cells

  • Authors:
    • Takako Akazawa
    • Kohichiroh Yasui
    • Yasuyuki Gen
    • Nobuhisa  Yamada
    • Akira Tomie
    • Osamu  Dohi
    • Hironori Mitsuyoshi
    • Nobuaki Yagi
    • Yoshito Itoh
    • Yuji Naito
    • Toshikazu Yoshikawa

  • View Affiliations / Copyright

    Affiliations: Department of Molecular Gastroenterology and Hepatology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto 602‑8566, Japan
  • Pages: 1849-1853
    |
    Published online on: March 29, 2013
       https://doi.org/10.3892/ol.2013.1278
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Abstract

DNA copy number aberrations in human biliary tract cancer (BTC) cell lines were investigated using a high‑density oligonucleotide microarray. A novel homozygous deletion was detected at chromosomal region 7p21.3 in the OZ cell line. Further validation experiments using genomic PCR revealed a homozygous deletion of a single gene, plant homeodomain (PHD) finger protein 14 (PHF14). No PHF14 mRNA or protein expression was detected, thus demonstrating the absence of PHF14 expression in the OZ cell line. Although the PHD finger protein is considered to be involved in chromatin‑mediated transcriptional regulation, little is known about the function of PHF14 in cancer. The present study observed that the knock down of PHF14 using small interfering RNA (siRNA) enhanced the growth of the BTC cells. These observations suggest that aberrant PHF14 expression may have a role in the tumorigenesis of BTC.
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Copy and paste a formatted citation
Spandidos Publications style
Akazawa T, Yasui K, Gen Y, Yamada N, Tomie A, Dohi O, Mitsuyoshi H, Yagi N, Itoh Y, Naito Y, Naito Y, et al: Aberrant expression of the PHF14 gene in biliary tract cancer cells . Oncol Lett 5: 1849-1853, 2013.
APA
Akazawa, T., Yasui, K., Gen, Y., Yamada, N., Tomie, A., Dohi, O. ... Yoshikawa, T. (2013). Aberrant expression of the PHF14 gene in biliary tract cancer cells . Oncology Letters, 5, 1849-1853. https://doi.org/10.3892/ol.2013.1278
MLA
Akazawa, T., Yasui, K., Gen, Y., Yamada, N., Tomie, A., Dohi, O., Mitsuyoshi, H., Yagi, N., Itoh, Y., Naito, Y., Yoshikawa, T."Aberrant expression of the PHF14 gene in biliary tract cancer cells ". Oncology Letters 5.6 (2013): 1849-1853.
Chicago
Akazawa, T., Yasui, K., Gen, Y., Yamada, N., Tomie, A., Dohi, O., Mitsuyoshi, H., Yagi, N., Itoh, Y., Naito, Y., Yoshikawa, T."Aberrant expression of the PHF14 gene in biliary tract cancer cells ". Oncology Letters 5, no. 6 (2013): 1849-1853. https://doi.org/10.3892/ol.2013.1278
Copy and paste a formatted citation
x
Spandidos Publications style
Akazawa T, Yasui K, Gen Y, Yamada N, Tomie A, Dohi O, Mitsuyoshi H, Yagi N, Itoh Y, Naito Y, Naito Y, et al: Aberrant expression of the PHF14 gene in biliary tract cancer cells . Oncol Lett 5: 1849-1853, 2013.
APA
Akazawa, T., Yasui, K., Gen, Y., Yamada, N., Tomie, A., Dohi, O. ... Yoshikawa, T. (2013). Aberrant expression of the PHF14 gene in biliary tract cancer cells . Oncology Letters, 5, 1849-1853. https://doi.org/10.3892/ol.2013.1278
MLA
Akazawa, T., Yasui, K., Gen, Y., Yamada, N., Tomie, A., Dohi, O., Mitsuyoshi, H., Yagi, N., Itoh, Y., Naito, Y., Yoshikawa, T."Aberrant expression of the PHF14 gene in biliary tract cancer cells ". Oncology Letters 5.6 (2013): 1849-1853.
Chicago
Akazawa, T., Yasui, K., Gen, Y., Yamada, N., Tomie, A., Dohi, O., Mitsuyoshi, H., Yagi, N., Itoh, Y., Naito, Y., Yoshikawa, T."Aberrant expression of the PHF14 gene in biliary tract cancer cells ". Oncology Letters 5, no. 6 (2013): 1849-1853. https://doi.org/10.3892/ol.2013.1278
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