Thyroid gland metastasis arising from breast cancer: A case report

Yang,Mei; Wang,Wei; Zhang,Chenfang

doi:10.3892/ol.2013.1287

June 2013 Volume 5 Issue 6

Full Size Image

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

An International Open Access Journal Devoted to General Medicine.

June 2013 Volume 5 Issue 6

Full Size Image

Case Report

Thyroid gland metastasis arising from breast cancer: A case report

Authors:
- Mei Yang
- Wei Wang
- Chenfang Zhang
View Affiliations / Copyright

Affiliations: Department of General Surgery, General Hospital of Guangzhou Military Command of PLA, Guangzhou 510010, P.R. China, Department of Pathology, General Hospital of Guangzhou Military Command of PLA, Guangzhou 510010, P.R. China
Pages: 1836-1838
|
Published online on: April 3, 2013

https://doi.org/10.3892/ol.2013.1287
Expand metrics +

Abstract

The thyroid gland is an uncommon site for metastasis to develop and thus metastases arising from breast cancer are rarely observed. In the present study, we describe a case of a 45‑year‑old female with a three-year history of breast cancer who presented with a thyroid mass that was diagnosed as metastatic breast carcinoma by histopathological analysis of the subtotal thyroidectomy specimen. To ascertain the diagnosis of metastatic breast cancer, we evaluated two types of markers; those that possessed a similar expression status in the original and metastatic lesions [ER, PR and CerbB-2 (HER2/neu)], and those that are capable of differentiating between metastatic lesions and the surrounding thyroid components (TG and TTF-1). The results showed that ER, PR and CerbB-2 demonstrated a similar expression pattern in primary breast carcinoma and thyroid lesions. Meanwhile, in the thyroid lesions, the malignant cells showed negative staining for TG and TTF-1, which confirmed that lesions were not thyroid in origin. This case may prompt clinicians that although thyroid gland are uncommon metastatic site, a diagnosis of metastatic disease should be considered when new aggregates are identified in the thyroid glands and histopathological analysis may aid the diagnosis.

View Figures

View References

1	Irvin W Jr, Muss HB and Mayer DK: Symptom management in metastatic breast cancer. Oncologist. 16:1203–1214. 2011. View Article : Google Scholar : PubMed/NCBI
2	Lam KY and Lo CY: Metastatic tumors of the thyroid gland: a study of 79 cases in Chinese patients. Arch Pathol Lab Med. 122:37–41. 1998.PubMed/NCBI
3	Gerges AS, Shehata SR and Gouda IA: Metastasis to the thyroid gland; unusual site of metastasis. J Egypt Natl Canc Inst. 18:67–72. 2006.PubMed/NCBI
4	Chen H, Nicol TL and Udelsman R: Clinically significant, isolated metastatic disease to the thyroid gland. World J Surg. 23:177–180. 1999. View Article : Google Scholar : PubMed/NCBI
5	Willis RA: Metastatic Tumours in the Thyreoid Gland. Am J Pathol. 7:187–208. 1931.PubMed/NCBI
6	Idirisinghe PK, Thike AA, Cheok PY, et al: Hormone receptor and c-ERBB2 status in distant metastatic and locally recurrent breast cancer. Pathologic correlations and clinical significance. Am J Clin Pathol. 133:416–429. 2010. View Article : Google Scholar
7	Wagner K, Arciaga R, Siperstein A, et al: Thyrotropin receptor/thyroglobulin messenger ribonucleic acid in peripheral blood and fine-needle aspiration cytology: diagnostic synergy for detecting thyroid cancer. J Clin Endocrinol Metab. 90:1921–1924. 2005. View Article : Google Scholar
8	Katoh R, Miyagi E, Nakamura N, et al: Expression of thyroid transcription factor-1 (TTF-1) in human C cells and medullary thyroid carcinomas. Hum Pathol. 31:386–393. 2000. View Article : Google Scholar

Journals

International Journal of Molecular Medicine

International Journal of Oncology

Molecular Medicine Reports

Oncology Reports

Experimental and Therapeutic Medicine

Oncology Letters

Biomedical Reports

Molecular and Clinical Oncology

World Academy of Sciences Journal

International Journal of Functional Nutrition

International Journal of Epigenetics

Medicine International

Thyroid gland metastasis arising from breast cancer: A case report

This article is mentioned in:

Abstract

Figure 1

Figure 2

Related Articles