Gallbladder carcinosarcoma accompanied with bile duct tumor thrombi: A case report
- Authors:
- Yan Wang
- Xiaodong Gu
- Zhenyang Li
- Jianbin Xiang
- Zongyou Chen
View Affiliations
Affiliations: Department of General Surgery, Huashan Hospital, Fudan University, Shanghai 200040, P.R. China
- Published online on: April 4, 2013 https://doi.org/10.3892/ol.2013.1289
-
Pages:
1809-1812
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Abstract
Gallbladder carcinosarcoma is one of the rarest subsets of gallbladder malignancies. The first case of carcinosarcoma of the gallbladder was reported in 1907. To date, <100 cases have been reported in the English literature. The present study reports a case of gallbladder carcinosarcoma accompanied with tumor thrombi, presenting as a soft tissue mass in the common bile duct and resulting in the obstruction and inflammation of the biliary tract. Initially, the patient was diagnosed with a gallbladder tumor and choledocholithiasis. No cases of carcinosarcoma of the gallbladder accompanied with bile duct tumor thrombus formation have been reported to date. A cholecystectomy with liver segmentectomy (S4a+S5) and a lymph node dissection were performed. The presence of a tumor thrombus in the common bile duct was confirmed by analysis of a frozen section during surgery. Resection of the extrahepatic bile duct and Roux‑en‑Y type hepatic cholangiojejunostomy were also performed. In addition, the gallbladder carcinosarcoma was observed to produce α‑fetoprotein. The patient underwent an uneventful post‑operative recovery and, to date, no clinical or radiological evidence of disease recurrence or metastasis has been identified. Carcinosarcoma of the gallbladder accompanied with tumor thrombi is extremely rare. Tumor thrombi in the common bile duct may easily be misdiagnosed as choledocholithiasis. The treatment and prognosis of gallbladder carcinosarcoma is similar to that of gallbladder carcinoma.
View References
|
1
|
Shimada K, Iwase K, Aono T, et al:
Carcinosarcoma of the gallbladder producing alpha-fetoprotein and
manifesting as leukocytosis with elevated serum granulocyte
colony-stimulating factor: report of a case. Surg Today.
39:241–246. 2009. View Article : Google Scholar : PubMed/NCBI
|
|
2
|
Kim MJ, Yu E and Ro JY: Sarcomatoid
carcinoma of the gall bladder with a rhabdoid tumor component. Arch
Pathol Lab Med. 127:e406–e408. 2003.PubMed/NCBI
|
|
3
|
Takahashi Y, Fukushima J, Fukusato T and
Shiga J: Sarcomatoid carcinoma with components of small cell
carcinoma and undifferentiated carcinoma of the gallbladder. Pathol
Int. 54:866–871. 2004. View Article : Google Scholar : PubMed/NCBI
|
|
4
|
Ajiki T, Nakamura T, Fujino Y, et al:
Carcinosarcoma of the gallbladder with chondroid differentiation. J
Gastroenterol. 37:966–971. 2002. View Article : Google Scholar : PubMed/NCBI
|
|
5
|
Uzun MA, Koksal N, Gunerhan Y, et al:
Carcinosarcoma of the gallbladder: report of a case. Surg Today.
39:168–171. 2009. View Article : Google Scholar : PubMed/NCBI
|
|
6
|
Sung MT, Wang M, MacLennan GT, et al:
Histogenesis of sarcomatoid urothelial carcinoma of the urinarv
bladder: evidence for a common clonal origin with divergent
differentiation. J Pathol. 211:420–430. 2007. View Article : Google Scholar : PubMed/NCBI
|
|
7
|
Dacic S, Finkelstein SD, Sasatomi E, et
al: Molecular pathogenesis of pulmonary carcinosarcoma as
determined by microdissection-based allelotyping. Am J Surg Pathol.
26:510–516. 2002. View Article : Google Scholar : PubMed/NCBI
|
|
8
|
Born MW, Ramey WG, Ryan SF and Gordon PE:
Carcinosarcoma and carcinoma of the gallbladder. Cancer.
53:2171–2177. 1984. View Article : Google Scholar : PubMed/NCBI
|
|
9
|
Wu JT: Serum alpha-fetoprotein and its
lectin reactivity in liver diseases: a review. Ann Clin Lab Sci.
20:98–105. 1990.PubMed/NCBI
|
|
10
|
Hayashi K, Hiraki M, Yamashita Y, et al: A
case of cancer of the gallbladder with a high level of
alphafetoprotein. Nippon Rinsyo Geka Gakkai Zasshi (J Jpn Soc Clin
Surg). 55:3161–3165. 1994.(In Japanese).
|
|
11
|
Kubota K, Kakuta Y, Kawamura S, et al:
Undifferentiated spindle-cell carcinoma of the gallbladder: an
immunohistochemical study. J Hepatobiliary Pancreat Surg.
13:468–471. 2006. View Article : Google Scholar : PubMed/NCBI
|
