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International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

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Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

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Article

Beclin 1 and nuclear factor-κBp65 are upregulated in hepatocellular carcinoma

  • Authors:
    • Kai‑Fu Kang
    • Xiao‑Wei Wang
    • Xiao‑Wu Chen
    • Zi‑Jing Kang
    • Xin Zhang
    • Rhonda R. Wilbur
    • Feng Cheng
    • Shu‑Feng Zhou
  • View Affiliations / Copyright

    Affiliations: Department of Pathology, The First People's Hospital of Shunde, Southern Medical University, Shunde, Foshan, Guangdong 528300, P.R. China, Department of General Surgery, The First People's Hospital of Shunde, Southern Medical University, Shunde, Foshan, Guangdong 528300, P.R. China, Department of Pharmaceutical Sciences, College of Pharmacy, University of South Florida, Tampa, FL 33612, USA
  • Pages: 1813-1818
    |
    Published online on: April 16, 2013
       https://doi.org/10.3892/ol.2013.1307
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Abstract

There are no sensitive and specific biomarkers that aid in the clinical diagnosis and prognosis of hepatocellular carcinoma (HCC). The aim of the present study was to determine the mRNA and protein expression levels of beclin 1 (BECN1) and nuclear factor‑κB (NF‑κB)p65 in patients with HCC, to evaluate their value as potential diagnostic and prognostic biomarkers. Immunohistochemistry and in situ hybridization were used to detect the expression of hepatic BECN1 and NF‑kBp65 in patients with HCC, hepatitis B virus (HBV) or cirrhosis, as compared with the expression levels in healthy subjects. The expression level of the BECN1 protein in the HCC tissue was significantly high compared with that in the cirrhotic, hepatitis and normal tissues. The expression of the BECN1 protein in the hepatitis tissue was significantly high compared with that of the cirrhotic and normal tissues. The expression of the BECN1 mRNA in the cancer tissue was significantly high compared with that of the cirrhotic and normal tissues, and the expression of the BECN1 mRNA in the hepatitis tissue was significantly higher than that of the cirrhotic and normal tissues. The expression of the NF‑κBp65 protein in the cancer tissue was significantly high compared with that of the cirrhotic, hepatitis and normal tissues. The expression of the NF‑κBp65 mRNA in the cancer tissue was significantly high compared with that of the cirrhotic, hepatitis and normal tissues. BECN1 expression was positively correlated with NF‑κBp65 expression in HCC. The abnormal expression of BECN1 and NF‑κBp65 was closely associated with the development of HCC. Finally, a search in GeneGo pathway database observed a link between BECN1 and NF-κBp65 through multiple proteins. These results indicate that BECN1 and NF‑κBp65 are upregulated in HCC, and that they may serve as useful biomarkers for HCC.
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Copy and paste a formatted citation
Spandidos Publications style
Kang KF, Wang XW, Chen XW, Kang ZJ, Zhang X, Wilbur RR, Cheng F and Zhou SF: Beclin 1 and nuclear factor-κBp65 are upregulated in hepatocellular carcinoma. Oncol Lett 5: 1813-1818, 2013.
APA
Kang, K., Wang, X., Chen, X., Kang, Z., Zhang, X., Wilbur, R.R. ... Zhou, S. (2013). Beclin 1 and nuclear factor-κBp65 are upregulated in hepatocellular carcinoma. Oncology Letters, 5, 1813-1818. https://doi.org/10.3892/ol.2013.1307
MLA
Kang, K., Wang, X., Chen, X., Kang, Z., Zhang, X., Wilbur, R. R., Cheng, F., Zhou, S."Beclin 1 and nuclear factor-κBp65 are upregulated in hepatocellular carcinoma". Oncology Letters 5.6 (2013): 1813-1818.
Chicago
Kang, K., Wang, X., Chen, X., Kang, Z., Zhang, X., Wilbur, R. R., Cheng, F., Zhou, S."Beclin 1 and nuclear factor-κBp65 are upregulated in hepatocellular carcinoma". Oncology Letters 5, no. 6 (2013): 1813-1818. https://doi.org/10.3892/ol.2013.1307
Copy and paste a formatted citation
x
Spandidos Publications style
Kang KF, Wang XW, Chen XW, Kang ZJ, Zhang X, Wilbur RR, Cheng F and Zhou SF: Beclin 1 and nuclear factor-κBp65 are upregulated in hepatocellular carcinoma. Oncol Lett 5: 1813-1818, 2013.
APA
Kang, K., Wang, X., Chen, X., Kang, Z., Zhang, X., Wilbur, R.R. ... Zhou, S. (2013). Beclin 1 and nuclear factor-κBp65 are upregulated in hepatocellular carcinoma. Oncology Letters, 5, 1813-1818. https://doi.org/10.3892/ol.2013.1307
MLA
Kang, K., Wang, X., Chen, X., Kang, Z., Zhang, X., Wilbur, R. R., Cheng, F., Zhou, S."Beclin 1 and nuclear factor-κBp65 are upregulated in hepatocellular carcinoma". Oncology Letters 5.6 (2013): 1813-1818.
Chicago
Kang, K., Wang, X., Chen, X., Kang, Z., Zhang, X., Wilbur, R. R., Cheng, F., Zhou, S."Beclin 1 and nuclear factor-κBp65 are upregulated in hepatocellular carcinoma". Oncology Letters 5, no. 6 (2013): 1813-1818. https://doi.org/10.3892/ol.2013.1307
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