Basaloid squamous cell carcinoma of the maxillary sinus: Report of two cases in association with cathepsin K expression

Ishida,Mitsuaki; Okabe,Hidetoshi

doi:10.3892/ol.2013.1311

June 2013 Volume 5 Issue 6

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June 2013 Volume 5 Issue 6

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Article

Basaloid squamous cell carcinoma of the maxillary sinus: Report of two cases in association with cathepsin K expression

Authors:
- Mitsuaki Ishida
- Hidetoshi Okabe
View Affiliations / Copyright

Affiliations: Department of Clinical Laboratory Medicine and Division of Diagnostic Pathology, Shiga University of Medical Science, Otsu, Shiga, Japan
Pages: 1755-1759
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Published online on: April 17, 2013

https://doi.org/10.3892/ol.2013.1311
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Abstract

Basaloid squamous cell carcinoma (BSCC) is a rare variant of squamous cell carcinoma. The occurrence of BSCC in the nasal cavity is extremely rare. In the present study, two cases of BSCC occurring in the maxillary sinus are reported and the clinicopathological features and immunohistochemical characteristics of this rare tumor are discussed. Two patients, aged 85 (case 1) and 60 years (case 2), presented with nasal tumors and persistent nasal obstruction. In each case, the biopsy or resected specimen of the maxillary sinus tumor revealed an infiltrative proliferation of solid epithelial nests composed of basaloid cells exhibiting hyperchromatic nuclei without conspicuous nucleoli and scant cytoplasm. Mitotic figures were frequently observed and spherical hyalinized materials were present within the tumor nests. Immunohistochemically, the tumor cells exhibited diffuse positive immunoreactivity for p63 and perinuclear dot‑like positivity for vimentin, leading to a final diagnosis of BSCC of the maxillary sinus. Furthermore, it was demonstrated for the first time in the two cases that cathepsin K, a cysteine protease with marked collagenolytic and elastolytic activities, was expressed in a diffuse manner. One patient (case 2) succumbed to multiple metastases, while the other (case 1) remains alive with the disease. In conclusion, it was demonstrated that cathepsin K was immunopositive in two cases of BSCC of the maxillary sinus and that it may be involved in tumor invasion by this highly aggressive carcinoma.

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1	Cardesa A, Zidar N and Ereño C: Basaloid squamous cell carcinoma. World Health Organization Classification of Tumours. Pathology and Genetics of Head and Neck Tumours. Barnes L, Eveson JW, Reichart P and Sidransky D: IARC Press; Lyon: pp. 124–125. 2005
2	Wain SL, Kier R, Vollmer RT and Bossen EH: Basaloid-squamous cell carcinoma of the tongue, hypopharynx, and larynx: report of 10 cases. Hum Pathol. 17:1158–1166. 1986. View Article : Google Scholar : PubMed/NCBI
3	Oikawa K, Tabuchi K, Nomura M, et al: Basaloid squamous cell carcinoma of the maxillary sinus: a report of two cases. Auris Nasus Larynx. 34:119–123. 2007. View Article : Google Scholar : PubMed/NCBI
4	Paulino AF, Singh B, Shah JP and Huvos AG: Basaloid squamous cell carcinoma of the head and neck. Laryngoscope. 110:1479–1482. 2000. View Article : Google Scholar : PubMed/NCBI
5	Wan SK, Chan JK and Tse KC: Basaloid-squamous carcinoma of the nasal cavity. J Laryngol Otol. 106:370–371. 1992. View Article : Google Scholar : PubMed/NCBI
6	Wieneke JA, Thompson LDR and Wenig BM: Basaloid squamous cell carcinoma of the sinonasal tract. Cancer. 85:841–854. 1999. View Article : Google Scholar : PubMed/NCBI
7	Lu SY, Eng HL, Huang CC, Chien CY, Lui CC and Lin JW: Basaloid squamous cell carcinoma of the sinonasal tract: report of two cases. Otolaryngol Head Neck Surg. 134:883–885. 2006. View Article : Google Scholar : PubMed/NCBI
8	Yu GY, Gao Y, Peng X, Chen Y, Zhao FY and Wu MJ: A clinicopathologic study on basaloid squamous cell carcinoma in the oral and maxillofacial region. Int J Oral Maxillofac Surg. 37:1003–1008. 2008. View Article : Google Scholar : PubMed/NCBI
9	Lee JS, Ko IJ, Jun SY and Kim JY: Basaloid squamous cell carcinoma in nasal cavity. Clin Exp Otorhinolaryngol. 2:207–210. 2009. View Article : Google Scholar : PubMed/NCBI
10	Ereño C, Gaafar A, Garmendia M, Etxezarraga C, Bilbao FJ and López JI: Basaloid squamous cell carcinoma of the head and neck: a clinicopathological and follow-up study of 40 cases and review of the literature. Head and Neck Pathol. 2:83–91. 2008.PubMed/NCBI
11	Barnes L, Ferlito A, Altavilla G, MacMillan C, Rinaldo A and Doglioni C: Basaloid squamous cell carcinoma of the head and neck: clinicopathological features and differential diagnosis. Ann Otol Rhinol Laryngol. 105:75–82. 1996. View Article : Google Scholar : PubMed/NCBI
12	Emanuel P, Wang B, Wu M and Burstein DE: p63 immunohistochemistry in the distinction of adenoid cystic carcinoma from basaloid squamous cell carcinoma. Mod Pathol. 18:645–650. 2005. View Article : Google Scholar : PubMed/NCBI
13	Garnero P, Borel O, Byrjalsen I, et al: The collagenolytic activity of cathepsin K is unique among mammalian proteinases. J Biol Chem. 273:32347–32352. 1998. View Article : Google Scholar : PubMed/NCBI
14	Mohamed MM and Sloane BF: Cysteine cathepsins: multifunctional enzymes in cancer. Nat Rev Cancer. 6:764–775. 2006. View Article : Google Scholar : PubMed/NCBI
15	Quintanilla-Dieck MJ, Codriansky K, Keady M, et al: Cathepsin K in melanoma invasion. J Invest Dermatol. 128:2281–2288. 2008. View Article : Google Scholar : PubMed/NCBI
16	Ishida M, Kojima F and Okabe H: Cathepsin K expression in basal cell carcinoma. Eur Acad Dermatol Venereol. 27:e128–e130. 2013. View Article : Google Scholar : PubMed/NCBI
17	Littlewood-Evans AJ, Bilbe G, Bowler WB, et al: The osteoclast-associated protease cathepsin K is expressed in human breast cancer. Cancer Res. 57:5386–5390. 1997.PubMed/NCBI
18	Rapa I, Volante M, Cappia S, et al: Cathepsin K is selectively expressed in the stroma of lung adenocarcinoma but not in bronchioloalveolar carcinoma. A useful marker of invasive growth. Am J Clin Pathol. 125:847–854. 2006. View Article : Google Scholar : PubMed/NCBI
19	Yan X, Takahara M, Xie L, et al: Stromal expression of cathepsin K in squamous cell carcinoma. Eur Acad Dermatol Venereol. 25:362–365. 2011. View Article : Google Scholar : PubMed/NCBI
20	Szumilo J, Burdan F, Zinkiewicz K, et al: Expression of syndecan-1 and cathepsin D and K in advanced esophageal squamous cell carcinoma. Folia Histochem Cytobiol. 47:571–578. 2009.PubMed/NCBI