Aberrant expression of ZNF268 alters the growth and migration of ovarian cancer cells

Hu,Li; Wang,Wei; Cai,Jinyang; Luo,Jun; Huang,Yi; Xiong,Shilu; Li,Wenxin; Guo,Mingxiong

doi:10.3892/ol.2013.1318

Aberrant expression of ZNF268 alters the growth and migration of ovarian cancer cells

Authors:
- Li Hu
- Wei Wang
- Jinyang Cai
- Jun Luo
- Yi Huang
- Shilu Xiong
- Wenxin Li
- Mingxiong Guo
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Affiliations: State Key Laboratory of Virology, College of Life Sciences, Wuhan University, Wuhan, Hubei 430072, P.R. China, Department of Pathology, Zhongnan Hospital, Wuhan University, Wuhan, Hubei 430071, P.R. China, Department of Gynecologic Oncology, Hubei Cancer Hospital, Wuhan, Hubei 430079, P.R. China
Published online on: April 24, 2013 https://doi.org/10.3892/ol.2013.1318
Pages: 49-54

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Abstract

Ovarian cancer is one of the most lethal gynaecological cancers worldwide. However, the mechanisms underlying ovarian carcinogenesis are not well understood. The present study used immunostaining, western blotting and quantitative real‑time PCR to demonstrate that ZNF268 is overexpressed in human ovarian carcinomas. ZNF268‑knockdown increased the viability, colony formation and growth of in vivo xenografts of ovarian carcinoma SKOV-3 cells, whereas SKOV-3 cell migration was inhibited. Furthermore, it was demonstrated that the knockdown of ZNF268 may increase SKOV-3 cell growth by promoting cell cycle progression. The findings suggest that ZNF268 is a novel protein involved in ovarian carcinogenesis and that it may aid in the understanding of the mechanisms of ovarian carcinogenesis.

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