Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Oncology Letters
Join Editorial Board Propose a Special Issue
Print ISSN: 1792-1074 Online ISSN: 1792-1082
Journal Cover
July 2013 Volume 6 Issue 1

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
July 2013 Volume 6 Issue 1

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article

Aberrant expression of ZNF268 alters the growth and migration of ovarian cancer cells

  • Authors:
    • Li Hu
    • Wei Wang
    • Jinyang Cai
    • Jun Luo
    • Yi Huang
    • Shilu Xiong
    • Wenxin Li
    • Mingxiong Guo
  • View Affiliations / Copyright

    Affiliations: State Key Laboratory of Virology, College of Life Sciences, Wuhan University, Wuhan, Hubei 430072, P.R. China, Department of Pathology, Zhongnan Hospital, Wuhan University, Wuhan, Hubei 430071, P.R. China, Department of Gynecologic Oncology, Hubei Cancer Hospital, Wuhan, Hubei 430079, P.R. China
  • Pages: 49-54
    |
    Published online on: April 24, 2013
       https://doi.org/10.3892/ol.2013.1318
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

Ovarian cancer is one of the most lethal gynaecological cancers worldwide. However, the mechanisms underlying ovarian carcinogenesis are not well understood. The present study used immunostaining, western blotting and quantitative real‑time PCR to demonstrate that ZNF268 is overexpressed in human ovarian carcinomas. ZNF268‑knockdown increased the viability, colony formation and growth of in vivo xenografts of ovarian carcinoma SKOV-3 cells, whereas SKOV-3 cell migration was inhibited. Furthermore, it was demonstrated that the knockdown of ZNF268 may increase SKOV-3 cell growth by promoting cell cycle progression. The findings suggest that ZNF268 is a novel protein involved in ovarian carcinogenesis and that it may aid in the understanding of the mechanisms of ovarian carcinogenesis.
View Figures

Figure 1

Figure 2

Figure 3

Figure 4

View References

1. 

Huntley S, Baggott DM, Hamilton AT, Tran-Gyamfi M, et al: A comprehensive catalog of human KRAB-associated zinc finger genes: insights into the evolutionary history of a large family of transcriptional repressors. Genome Res. 16:669–677. 2006. View Article : Google Scholar : PubMed/NCBI

2. 

Urrutia R: KRAB-containing zinc-finger repressor proteins. Genome Biol. 4:2312003. View Article : Google Scholar : PubMed/NCBI

3. 

Margolin JF, Friedman JR, Meyer WK, Vissing H, et al: Krüppel-associated boxes are potent transcriptional repression domains. Proc Natl Acad Sci USA. 91:4509–4513. 1994.

4. 

Mark C, Abrink M and Hellman L: Comparative analysis of KRAB zinc finger proteins in rodents and man: evidence for several evolutionarily distinct subfamilies of KRAB zinc finger genes. DNA Cell Biol. 18:381–396. 1999. View Article : Google Scholar : PubMed/NCBI

5. 

Gou DM, Sun Y, Gao L, Chow LM, et al: Cloning and characterization of a novel Krüppel-like zinc finger gene, ZNF268, expressed in early human embryo. Biochim Biophys Acta. 1518:306–310. 2001.

6. 

Shao H, Zhu C, Zhao Z, Guo M, et al: KRAB-containing zinc finger gene ZNF268 encodes multiple alternatively spliced isoforms that contain transcription regulatory domains. Int J Mol Med. 18:457–463. 2006.PubMed/NCBI

7. 

Sun Y, Gou DM, Liu H, Peng X and Li WX: The KRAB domain of zinc finger gene ZNF268: a potential transcriptional repressor. IUBMB Life. 55:127–131. 2003. View Article : Google Scholar : PubMed/NCBI

8. 

Wang W, Guo M, Hu L, Cai J, et al: The zinc finger protein ZNF268 is overexpressed in human cervical cancer and contributes to tumorigenesis via enhancing NF-κB signaling. J Biol Chem. 287:42856–42866. 2012.PubMed/NCBI

9. 

Guo MX, Wang D, Shao HJ, Qiu HL, et al: Transcription of human zinc finger ZNF268 gene requires an intragenic promoter element. J Biol Chem. 281:24623–24636. 2006. View Article : Google Scholar : PubMed/NCBI

10. 

Sun Y, Shao H, Li Z, Liu J, et al: ZNF268, a novel kruppel-like zinc finger protein, is implicated in early human liver development. Int J Mol Med. 14:971–975. 2004.PubMed/NCBI

11. 

Krackhardt AM, Witzens M, Harig S, Hodi FS, et al: Identification of tumor-associated antigens in chronic lymphocytic leukemia by SEREX. Blood. 100:2123–2131. 2002. View Article : Google Scholar : PubMed/NCBI

12. 

Wang D, Guo MX, Hu HM, Zhao ZZ, et al: Human T-cell leukemia virus type 1 oncoprotein tax represses ZNF268 expression through the cAMP-responsive element-binding protein/activating transcription factor pathway. J Biol Chem. 283:16299–16308. 2008. View Article : Google Scholar

13. 

Zhao Z, Wang D, Zhu C, Shao H, et al: Aberrant alternative splicing of human zinc finger gene ZNF268 in human hematological malignancy. Oncol Rep. 20:1243–1248. 2008.PubMed/NCBI

14. 

Zeng Y, Wang W, Ma J, Wang X, et al: Knockdown of ZNF268, which is transcriptionally downregulated by GATA-1, promotes proliferation of K562 cells. PLoS One. 7:e295182012. View Article : Google Scholar : PubMed/NCBI

15. 

Jemal A, Bray F, Center MM, Ferlay J, et al: Global cancer statistics. CA Cancer J Clin. 61:69–90. 2011. View Article : Google Scholar

16. 

Marugame T and Hirabayashi Y: Comparison of time trends in ovary cancer incidence (1973–1997) in East Asia, Europe, and the USA, from Cancer Incidence in Five Continents Vols IV VIII. Jpn J Clin Oncol. 37:802–803. 2007.PubMed/NCBI

17. 

Agarwal R and Kaye SB: Ovarian cancer: strategies for overcoming resistance to chemotherapy. Nat Rev Cancer. 3:502–516. 2003. View Article : Google Scholar : PubMed/NCBI

18. 

Paley PJ: Ovarian cancer screening: are we making any progress? Curr Opin Oncol. 13:399–402. 2001. View Article : Google Scholar : PubMed/NCBI

19. 

Bast RC Jr, Hennessy B and Mills GB: The biology of ovarian cancer: new opportunities for translation. Nat Rev Cancer. 9:415–428. 2009. View Article : Google Scholar : PubMed/NCBI

20. 

Ropponen KM, Eskelinen MJ, Lipponen PK, Alhava EM and Kosma VM: Reduced expression of alpha catenin is associated with poor prognosis in colorectal carcinoma. J Clin Pathol. 52:10–16. 1999. View Article : Google Scholar : PubMed/NCBI

21. 

Sherr CJ: Cancer cell cycles. Science. 274:1672–1677. 1996. View Article : Google Scholar : PubMed/NCBI

22. 

Lauper N, Beck AR, Cariou S, Richman L, et al: Cyclin E2: a novel CDK2 partner in the late G1 and S phases of the mammalian cell cycle. Oncogene. 17:2637–2643. 1998. View Article : Google Scholar : PubMed/NCBI

23. 

Lundberg AS and Weinberg RA: Functional inactivation of the retinoblastoma protein requires sequential modification by at least two distinct cyclin-cdk complexes. Mol Cell Biol. 18:753–761. 1998.PubMed/NCBI

24. 

Cory G: Scratch-wound assay. Methods Mol Biol. 769:25–30. 2011. View Article : Google Scholar

25. 

Hanahan D and Weinberg RA: Hallmarks of cancer: the next generation. Cell. 144:646–674. 2011. View Article : Google Scholar : PubMed/NCBI

26. 

Maass N, Hojo T, Ueding M, Lüttges J, et al: Expression of the tumor suppressor gene Maspin in human pancreatic cancers. Clin Cancer Res. 7:812–817. 2001.PubMed/NCBI

27. 

El-Mansi MT and Williams AR: Evaluation of PTEN expression in cervical adenocarcinoma by tissue microarray. Int J Gynecol Cancer. 16:1254–1260. 2006. View Article : Google Scholar : PubMed/NCBI

28. 

Lee JS, Choi YD, Lee JH, Nam JH, et al: Expression of PTEN in the progression of cervical neoplasia and its relation to tumor behavior and angiogenesis in invasive squamous cell carcinoma. J Surg Oncol. 93:233–240. 2006. View Article : Google Scholar : PubMed/NCBI

29. 

He L, Ingram A, Rybak AP and Tang D: Shank-interacting protein-like 1 promotes tumorigenesis via PTEN inhibition in human tumor cells. J Clin Invest. 120:2094–2108. 2010. View Article : Google Scholar : PubMed/NCBI

30. 

Looman C, Abrink M, Mark C and Hellman L: KRAB zinc finger proteins: an analysis of the molecular mechanisms governing their increase in numbers and complexity during evolution. Mol Biol Evol. 19:2118–2130. 2002. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Hu L, Wang W, Cai J, Luo J, Huang Y, Xiong S, Li W and Guo M: Aberrant expression of ZNF268 alters the growth and migration of ovarian cancer cells. Oncol Lett 6: 49-54, 2013.
APA
Hu, L., Wang, W., Cai, J., Luo, J., Huang, Y., Xiong, S. ... Guo, M. (2013). Aberrant expression of ZNF268 alters the growth and migration of ovarian cancer cells. Oncology Letters, 6, 49-54. https://doi.org/10.3892/ol.2013.1318
MLA
Hu, L., Wang, W., Cai, J., Luo, J., Huang, Y., Xiong, S., Li, W., Guo, M."Aberrant expression of ZNF268 alters the growth and migration of ovarian cancer cells". Oncology Letters 6.1 (2013): 49-54.
Chicago
Hu, L., Wang, W., Cai, J., Luo, J., Huang, Y., Xiong, S., Li, W., Guo, M."Aberrant expression of ZNF268 alters the growth and migration of ovarian cancer cells". Oncology Letters 6, no. 1 (2013): 49-54. https://doi.org/10.3892/ol.2013.1318
Copy and paste a formatted citation
x
Spandidos Publications style
Hu L, Wang W, Cai J, Luo J, Huang Y, Xiong S, Li W and Guo M: Aberrant expression of ZNF268 alters the growth and migration of ovarian cancer cells. Oncol Lett 6: 49-54, 2013.
APA
Hu, L., Wang, W., Cai, J., Luo, J., Huang, Y., Xiong, S. ... Guo, M. (2013). Aberrant expression of ZNF268 alters the growth and migration of ovarian cancer cells. Oncology Letters, 6, 49-54. https://doi.org/10.3892/ol.2013.1318
MLA
Hu, L., Wang, W., Cai, J., Luo, J., Huang, Y., Xiong, S., Li, W., Guo, M."Aberrant expression of ZNF268 alters the growth and migration of ovarian cancer cells". Oncology Letters 6.1 (2013): 49-54.
Chicago
Hu, L., Wang, W., Cai, J., Luo, J., Huang, Y., Xiong, S., Li, W., Guo, M."Aberrant expression of ZNF268 alters the growth and migration of ovarian cancer cells". Oncology Letters 6, no. 1 (2013): 49-54. https://doi.org/10.3892/ol.2013.1318
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team