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July 2013 Volume 6 Issue 1

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International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

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International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

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Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

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Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

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Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

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Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

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International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

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Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

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International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

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Article

Expression and clinical significance of complement C3, complement C4b1 and apolipoprotein E in pancreatic cancer

  • Authors:
    • Jiong Chen
    • Wen Wu
    • Chunsheng Zhen
    • Hangchen Zhou
    • Renbao Yang
    • Longjiang Chen
    • Liwei Hu
  • View Affiliations / Copyright

    Affiliations: Department of General Surgery, Anhui Provincial Hospital Affiliated to Anhui Medical University, Hefei, Anhui 230001, P.R. China
  • Pages: 43-48
    |
    Published online on: April 30, 2013
       https://doi.org/10.3892/ol.2013.1326
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Abstract

Pancreatic cancer (PC) remains a devastating disease with a five‑year survival rate of <5%. The difficulty in making an early diagnosis and the frequent occurrence of metastasis are important reasons for this poor prognosis. In China, the incidence of PC has been increasing steadily. Therefore, the present study aimed to identify effective markers in the early and advanced stages of PC. The expression levels of complement C3, complement C4b1 and apolipoprotein E (ApoE) in the various stages of PC were assessed by immunohistochemistry, RT‑PCR and western blotting. Additionally, the statistical significance of the results was analyzed. The expression levels of complement C3, complement C4b1 and apoE were higher in PC compared with normal pancreatic tissues. No correlations were observed between complement C3 and tumor TNM staging or lymph node metastasis. However, complement C4b1 and apoE were markedly correlated with tumor TNM staging and lymph node metastasis. Complement C3 may be used as a marker for the diagnosis of early‑stage PC, while complement C4b1 and apoE are closely correlated with tumor development, reflecting the biological behavior of PC, and thus may be used as diagnostic markers of advanced PC.
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Copy and paste a formatted citation
Spandidos Publications style
Chen J, Wu W, Zhen C, Zhou H, Yang R, Chen L and Hu L: Expression and clinical significance of complement C3, complement C4b1 and apolipoprotein E in pancreatic cancer. Oncol Lett 6: 43-48, 2013.
APA
Chen, J., Wu, W., Zhen, C., Zhou, H., Yang, R., Chen, L., & Hu, L. (2013). Expression and clinical significance of complement C3, complement C4b1 and apolipoprotein E in pancreatic cancer. Oncology Letters, 6, 43-48. https://doi.org/10.3892/ol.2013.1326
MLA
Chen, J., Wu, W., Zhen, C., Zhou, H., Yang, R., Chen, L., Hu, L."Expression and clinical significance of complement C3, complement C4b1 and apolipoprotein E in pancreatic cancer". Oncology Letters 6.1 (2013): 43-48.
Chicago
Chen, J., Wu, W., Zhen, C., Zhou, H., Yang, R., Chen, L., Hu, L."Expression and clinical significance of complement C3, complement C4b1 and apolipoprotein E in pancreatic cancer". Oncology Letters 6, no. 1 (2013): 43-48. https://doi.org/10.3892/ol.2013.1326
Copy and paste a formatted citation
x
Spandidos Publications style
Chen J, Wu W, Zhen C, Zhou H, Yang R, Chen L and Hu L: Expression and clinical significance of complement C3, complement C4b1 and apolipoprotein E in pancreatic cancer. Oncol Lett 6: 43-48, 2013.
APA
Chen, J., Wu, W., Zhen, C., Zhou, H., Yang, R., Chen, L., & Hu, L. (2013). Expression and clinical significance of complement C3, complement C4b1 and apolipoprotein E in pancreatic cancer. Oncology Letters, 6, 43-48. https://doi.org/10.3892/ol.2013.1326
MLA
Chen, J., Wu, W., Zhen, C., Zhou, H., Yang, R., Chen, L., Hu, L."Expression and clinical significance of complement C3, complement C4b1 and apolipoprotein E in pancreatic cancer". Oncology Letters 6.1 (2013): 43-48.
Chicago
Chen, J., Wu, W., Zhen, C., Zhou, H., Yang, R., Chen, L., Hu, L."Expression and clinical significance of complement C3, complement C4b1 and apolipoprotein E in pancreatic cancer". Oncology Letters 6, no. 1 (2013): 43-48. https://doi.org/10.3892/ol.2013.1326
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