Serum vascular endothelial growth factor‑C levels: A possible diagnostic marker for lymph node metastasis in patients with primary non‑small cell lung cancer

Zhang,Yakun; Meng,Xue; Zeng,Hongsheng; Guan,Yan; Zhang,Qiong; Guo,Shen; Liu,Xiujiu; Guo,Qisen

doi:10.3892/ol.2013.1373

August 2013 Volume 6 Issue 2

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August 2013 Volume 6 Issue 2

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Article

Serum vascular endothelial growth factor‑C levels: A possible diagnostic marker for lymph node metastasis in patients with primary non‑small cell lung cancer

Authors:
- Yakun Zhang
- Xue Meng
- Hongsheng Zeng
- Yan Guan
- Qiong Zhang
- Shen Guo
- Xiujiu Liu
- Qisen Guo
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Affiliations: Department of Medical Oncology, Shandong Cancer Hospital, Shandong Academy of Medical Sciences, Jinan, Shandong 250117, P.R. China, Department of Radiation Oncology, Shandong Cancer Hospital, Shandong Academy of Medical Sciences, Jinan, Shandong 250117, P.R. China
Pages: 545-549
|
Published online on: June 4, 2013

https://doi.org/10.3892/ol.2013.1373
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Abstract

Accurate tumor staging is essential for selecting the appropriate treatment strategy for lung cancer. Computed tomography (CT), or positron emission tomography (PET), is the most commonly used non‑invasive staging method of lymph node (LN) metastases (LNM), but this method remains unsatisfactory. The present study measured vascular endothelial growth factor (VEGF)‑C levels in serum, tumor tissue and LNs to determine the correlation between serum VEGF‑C and LNM, and also assessed the usefulness of serum VEGF‑C as an additional diagnostic marker for identifying LNM. A total of 66 patients with non‑small cell lung carcinoma (NSCLC) or benign tumors of the lung were included in this study, and circulating VEGF‑C levels were assessed with enzyme‑linked immunosorbent assays. RNA fractions extracted from the tumor tissues and LNs were subjected to quantitative polymerase chain reaction (qPCR) to assess the mRNA levels of VEGF‑C. The VEGF‑C levels in serum, tumor tissue and LNM were significantly higher compared with the control group (P<0.05). The VEGF‑C levels of patients with LNM were significantly higher compared with those without LNM (P<0.05). The VEGF‑C levels in the serum, tumor tissue and LNM were significantly correlated (P<0.05). With regard to the diagnosis of LNM using VEGF‑C levels, the serum levels of VEGF‑C reached a sensitivity of 65.0% and a specificity of 72.2% when a cutoff value of 655.65 pg/ml was applied. Serum VEGF‑C levels may provide additional information for distinguishing between the absence and presence of LNM in patients with lung carcinoma. The evaluation of serum VEGF‑C is complementary to accurate LN staging in NSCLC.

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1.	Miller DL, Rowland CM, Deschamps C, et al: Surgical treatment of non-small cell lung cancer 1 cm or less in diameter. Ann Thorac Surg. 73:1545–1550. 2002. View Article : Google Scholar : PubMed/NCBI
2.	Nishida N, Yano H, Komai K, et al: Vascular endothelial growth factor C and vascular endothelial growth factor receptor 2 are related closely to the prognosis of patients with ovarian carcinoma. Cancer. 101:1364–1374. 2004. View Article : Google Scholar
3.	Cianfarani F, Mastroeni S, Odorisio T, et al: Expression of vascular endothelial growth factor-C in primary cutaneous melanoma predicts sentinel lymph node positivity. J Cutan Pathol. 39:826–834. 2012. View Article : Google Scholar : PubMed/NCBI
4.	Wang TB, Chen ZG, Wei XQ, et al: Serum vascular endothelial growth factor-C and lymphoangiogenesis are associated with the lymph node metastasis and prognosis of patients with colorectal cancer. ANZ J Surg. 81:694–699. 2011. View Article : Google Scholar : PubMed/NCBI
5.	Acs G, Paragh G, Rakosy Z, et al: The extent of retraction clefts correlates with lymphatic vessel density and VEGF-C expression and predicts nodal metastasis and poor prognosis in early-stage breast carcinoma. Mod Pathol. 25:163–177. 2012.PubMed/NCBI
6.	Tamura M and Ohta Y: Serum vascular endothelial growth factor-C level in patients with primary nonsmall cell lung carcinoma: a possible diagnostic tool for lymph node metastasis. Cancer. 98:1217–1222. 2003. View Article : Google Scholar
7.	McNeil TM and Chamberlain JM: Diagnostic anterior mediastinotomy. Ann Thorac Surg. 2:532–539. 1966. View Article : Google Scholar
8.	Kitajima K, Yamasaki E, Kaji Y, et al: Comparison of DWI and PET/CT in evaluation of lymph node metastasis in uterine cancer. World J Radiol. 4:207–214. 2012. View Article : Google Scholar : PubMed/NCBI
9.	Zhang L, Xi M, Deng XW, et al: Four-dimensional CT-based evaluation of volumetric modulated arc therapy for abdominal lymph node metastasis from hepatocellular carcinoma. J Radiat Res. 53:769–776. 2012.PubMed/NCBI
10.	Takenaka T, Yano T, Morodomi Y, et al: Prediction of true-negative lymph node metastasis in clinical IA non-small cell lung cancer by measuring standardized uptake values on positron emission tomography. Surg Today. 42:934–939. 2012. View Article : Google Scholar : PubMed/NCBI
11.	Geraldson CT, Stephenson JE, Lagrew JP, et al: Use of positron emission tomography in initial staging of nonsmall cell lung carcinoma: a regional teaching hospital experience. Am Surg. 78:305–308. 2012.PubMed/NCBI
12.	Kernstine KH, Mclaughlin KA, Menda Y, et al: Can FDG-PET reduce the need for mediastinoscopy in potentially resectable nonsmall cell lung cancer? Ann Thorac Surg. 73:394–401. 2002. View Article : Google Scholar : PubMed/NCBI

Journals

International Journal of Molecular Medicine

International Journal of Oncology

Molecular Medicine Reports

Oncology Reports

Experimental and Therapeutic Medicine

Oncology Letters

Biomedical Reports

Molecular and Clinical Oncology

World Academy of Sciences Journal

International Journal of Functional Nutrition

International Journal of Epigenetics

Medicine International

Serum vascular endothelial growth factor‑C levels: A possible diagnostic marker for lymph node metastasis in patients with primary non‑small cell lung cancer

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